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Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease
Publication Year: 2025 Source: Theranostics PMID: 40521190 DOI: 10.7150/thno.111583
Rationale: DNA-based nanomedicines have shown significant therapeutic potential for various diseases; however, efficiently utilizing DNA nanomedicines without chemicals or small-molecule drugs is still a major challenge. Methods: In this study, we presented programmed activated DNA hydrogel microcapsules (HAMs) specifically designed for the treatment of inflammatory bowel disease (IBD). It was …
The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease
Publication Year: 2025 Source: Front Nutr PMID: 40521353 DOI: 10.3389/fnut.2025.1606289
IBD, which includes Crohn's and ulcerative colitis, is associated with gut microbiota dysbiosis. The dysbiotic environment results in an elevation of harmful microbiota and a diminution of advantageous microbiota, leading to IBD. Interestingly, plant-based dietary compounds consisting of dietary fibers and polyphenols have demonstrated promise to be safe and successful …
ZnO@Cu5.4O Nanoparticle Alleviates Inflammatory Responses of Intestinal Epithelial Cells by Inhibiting the Expression of GSDMB
Publication Year: 2025 Source: ACS Omega PMID: 40521506 DOI: 10.1021/acsomega.5c02789
Inflammatory bowel disease is an idiopathic chronic inflammatory condition of the gastrointestinal tract, closely associated with autophagy and pyroptosis. Nanoparticles, as small-diameter particles, play a unique role in disease research. In this study, a one-pot method was used to synthesize ZnO@Cu5.4O nanoparticles and characterize them. To simulate the inflammatory process …
Epigenetics and Expression of the Wnt Signaling Pathway in Ulcerative Colitis
Publication Year: 2025 Source: Turk J Gastroenterol PMID: 40521787
BACKGROUND/AIMS: Secreted frizzled-related proteins (SFRPs) are antagonists that bind Wnt and inhibit signaling through this pathway. Secreted frizzled-related proteins are silenced by promoter methylation and cause hyperactivation of the Wnt pathway. In this study, the aim was to evaluate the relationship between methylation and expression of genes involved in the …
Correction to: Screen Failures and Causes in Inflammatory Bowel Disease Randomized Controlled Trials: A Study of 16 913 Screened Patients
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40521834
No Abstract
Can One Disease Hide Another?
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40521861
No Abstract
Twenty-Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40521877 DOI: 10.1111/apt.70240
BACKGROUND: The impact of advanced therapy prescribing on colectomy rates in ulcerative colitis (UC) is unknown with conflicting published evidence. AIM: To describe advanced therapy prescribing trends and colectomy rates for patients with UC in Lothian, UK between January 1st, 2004 and December 31st, 2023. METHODS: We obtained incidence and …
Dissatisfaction and Barriers in Electronic Health Record Use for Inflammatory Bowel Disease Patients: A Nationwide Survey of Major IBD Centers
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40522328 DOI: 10.14309/ajg.0000000000003598
BACKGROUND: Electronic health records (EHR) are a growing source of burden for clinicians treating inflammatory bowel disease (IBD). METHODS: We conducted an EHR survey study targeting IBD clinicians at leading IBD programs throughout the United States. RESULTS: Surveys were sent to 65 IBD participants, with 46 (70.8%) responses collected, 41 …
Editorial: Shooting in the Dark-The Problem With Empiric Antispasmodics for Abdominal Pain in Inflammatory Bowel Disease
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40522627
No Abstract
Comparative Predictive Utility of MM-SES-CD and SES-CD for Week 52 Endoscopic Remission in the Ileum and Colon in Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40522972
BACKGROUND: The Simple Endoscopic Score for Crohn's disease (SES-CD) and Modified Multiplier of the SES-CD (MM-SES-CD) are endoscopic scoring systems used to assess disease severity and response to therapy in CD. This study evaluates their utility at baseline in predicting endoscopic remission (ER) of the ileum and colon at week …
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