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Dualistic Implications of Angiotensin-Converting Enzyme 2 (ACE2) Expression in Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40522979
No Abstract
Food Compounds Associated With Disease Activity in Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40523028 DOI: 10.1093/ibd/izaf126
BACKGROUND: Diet plays a modulatory role in inflammatory bowel disease (IBD), but specific relevant dietary factors have yet to be identified. To advance our understanding, we performed multivariate analyses of food compound intakes using dietary data from an IBD cohort. METHODS: We used dietary and disease status data from IBD …
Resveratrol derivative SH-707 inhibits NLRP3 inflammasome activation via a sirtuin 1-dependent pathway
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40523327
The nucleotide-binding oligomerization domain-like receptors protein 3 (NLRP3) inflammasome is a protein complex that plays a crucial role in initiating immune responses to harmful stimuli. However, excessive activation of the NLRP3 inflammasome can cause acute and chronic inflammation, leading to the progression of various inflammatory diseases, such as arthritis, inflammatory …
The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation
Publication Year: 2025 Source: Nat Immunol PMID: 40524017
E3 ligases and RNA-binding protein-mediated dysregulation of proinflammatory cytokines leads to autoimmune and inflammatory diseases. However, whether RNA-binding E3 ligases can regulate specific proinflammatory cytokine expression remains unclear. Here we found that the RNA-binding E3 ligase MKRN2 selectively inhibits the expression of interleukin-6 (IL-6) in lipopolysaccharide-activated macrophages. LysM-Cre(+)Mkrn2(fl/fl) mice showed …
Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology
Publication Year: 2025 Source: Biomark Res PMID: 40524271 DOI: 10.1186/s40364-025-00802-1
BACKGROUND: The gut microbiome plays a key role in the development of inflammatory bowel disease (IBD), as imbalances in microbial composition are associated with immune dysfunction. However, the specific mechanisms by which certain microorganisms contribute to this process remain unclear. METHODS: Here, we employed a multi-omics approach on fecal samples …
Laparoscopic Optimal Excision of Deep Rectovaginal Endometriosis: Tips and Techniques
Publication Year: 2025 Source: Cureus PMID: 40525018
Endometriosis is a chronic progressive disease spectrum characterized by the presence of tissue resembling functioning endometrial glands and stroma outside the uterine cavity. These ectopic implants have a propensity to bleed, initiating an inflammatory response. One of the most severe forms is deep rectovaginal endometriosis, which is the most challenging …
Combination therapy using intestinal organoids and their extracellular vesicles for inflammatory bowel disease complicated with osteoporosis
Publication Year: 2025 Source: J Orthop Translat PMID: 40525095 DOI: 10.1016/j.jot.2025.05.008
BACKGROUND: Inflammatory bowel disease (IBD) with osteoporosis (OP) exhibits a clinically significant comorbidity, for which no effective treatment is currently available. Intestinal organoids (IOs), engineered through three-dimensional (3D) coculture systems, demonstrated intrinsic regenerative potentials. Additionally, extracellular vesicles derived from IOs (IOEVs) have been identified as potent nanoscale mediators capable of …
Differential Association Between Default Mode Network Connectivity and Attachment Styles in Healthy Individuals and Crohn's Disease Patients
Publication Year: 2025 Source: Brain Behav PMID: 40525267 DOI: 10.1002/brb3.70620
AIM: Crohn's disease (CD) is associated with psychological disorders and insecure attachment styles, potentially reflecting the long-lasting disease effect. Although functional magnetic resonance imaging (fMRI) studies revealed differences in CD patients relative to HC, the brain properties underlying the attachment dimensions in CD remain scarcely investigated. We carried out an …
[Construction of NK cell-conditional Cd226 knockout mice and preliminary investigation of their role in ulcerative colitis]
Publication Year: 2025 Source: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi PMID: 40525336
Objective To generate and characterize natural killer cell (NK cell)-conditional Cd226 gene knockout mice using Cre-loxP technology, and to explore the role of CD226 on NK cells in alleviating intestinal inflammation in a murine model of ulcerative colitis (UC). Methods NK cell-conditional Cd226 gene knockout mice were generated by crossing …
Hyperoside promotes autophagy of colonic epithelial cells to protect intestinal barrier function in ulcerative colitis
Publication Year: 2025 Source: Food Funct PMID: 40525776
Intestinal barrier defects represent a significant contributor to the development and progression of ulcerative colitis (UC). This study examined the protective effect of hyperoside (Hyp), a naturally occurring flavonol glycoside with anti-colitis potential, on intestinal barrier, and explored the underlying mechanisms based on the expression of barrier-related proteins. In mice …
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