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Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease
Publication Year: 2025 Source: Nat Immunol PMID: 40528029 DOI: 10.1038/s41590-025-02197-5
Inflammatory bowel disease (IBD) is a complex, multifactorial inflammatory disorder of the gut characterized by an imbalance in host-microbiota interactions. Here, we review how early events of IBD are shaped by gene-environment interactions, especially those involving microbial perturbations. Those perturbations eventually lead to chronic inflammation and tissue damage of the …
Annual Infliximab Monitoring After Treatment Optimization
Publication Year: 2025 Source: Dig Dis Sci PMID: 40528082 DOI: 10.1007/s10620-025-09166-w
Infliximab (IFX), a TNF-alpha inhibitor, remains a key treatment for inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, despite the emergence of new therapies. However, treatment failure due to primary non-response or loss of response is common and often linked to low IFX trough levels (TLs) or anti-drug …
Clinical outcomes of conventional versus extended mesenteric resection in limited ileo-colonic Crohn's disease: a systematic review and meta-analysis
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40528089
BACKGROUND: The role of intestinal mesentery and the extent of its resection as a determinant of outcomes post-bowel resection in Crohn's disease (CD) remains a subject of debate. We evaluated outcomes of conventional mesenteric resection (CMR) and compared it with extended mesenteric resection (EMR) in patients undergoing ileo-colic excision for …
Fecal microbiota transplantation from patients into animals to establish human microbiota-associated animal models: a scoping review
Publication Year: 2025 Source: J Transl Med PMID: 40528217
BACKGROUND: Fecal microbiota transplantation (FMT) from humans with specific medical conditions to animal models can demonstrate causality by inducing or exacerbating pathophenotypes, linking the gut microbiota to health outcomes. METHODS: We conducted a scoping review searching MEDLINE, EMBASE, Scopus, and Web of Science through July 2024 to identify human noninfectious …
Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD)
Publication Year: 2025 Source: BMJ Open PMID: 40328654 DOI: 10.1136/bmjopen-2025-099218
PURPOSE: There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures. PARTICIPANTS: Patients aged >/=18 years with gastrointestinal symptoms …
HiBC: a publicly available collection of bacterial strains isolated from the human gut
Publication Year: 2025 Source: Nat Commun PMID: 40328737
Numerous bacteria in the human gut microbiome remain unknown and/or have yet to be cultured. While collections of human gut bacteria have been published, few strains are accessible to the scientific community. We have therefore created a publicly available collection of bacterial strains isolated from the human gut. The Human …
Exploring the drug repurposing potential of lisinopril against TNBS-induced colitis in Wistar rats
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40328912 DOI: 10.1007/s00210-025-04212-w
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with a multifactorial etiology. Given the limitations and adverse effects of current therapies, there is a need for novel therapeutic approaches. Drug repurposing presents a promising opportunity to utilize medications with known safety and pharmacological profiles for …
Eosinophilic esophagitis patients report substantial disease burden comparable to more systemic immune-mediated diseases
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40329165 DOI: 10.1186/s12876-025-03942-8
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic Type 2 inflammation. One might assume that the disease-related impact on daily life is significantly smaller, given the relatively localized disease distribution, compared to more systemic immune-mediated diseases. This study aimed to evaluate the disease burden among various immune-mediated diseases, including EoE, inflammatory …
Incorporating Real-World Variability in Clinical IBD Research
Publication Year: 2025 Source: J Eval Clin Pract PMID: 40329440 DOI: 10.1111/jep.70117
No Abstract
The Effectiveness of Medical Therapies for Joint, Skin and Eye Extraintestinal Manifestations in IBD-An Umbrella Review
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40329548 DOI: 10.1111/apt.70181
BACKGROUND: Extraintestinal manifestations (EIMs) occur commonly in patients with inflammatory bowel disease (IBD), affecting joints, skin, eyes and other organs, and contributing to morbidity and long-term disability. AIMS: To synthesise evidence from systematic reviews (SRs) on the effectiveness and safety of medical treatments for IBD EIMs in IBD of joints, …
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