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Addressing the research gap in IBD and MASLD: Time for coordinated action
Publication Year: 2025 Source: Saudi J Gastroenterol PMID: 40329554 DOI: 10.4103/sjg.sjg_123_25
No Abstract
Intravenous and subcutaneous vedolizumab for moderately to severely active ulcerative colitis in Iran: a model-based cost-effectiveness evaluation
Publication Year: 2025 Source: Expert Rev Pharmacoecon Outcomes Res PMID: 40329592
OBJECTIVE: To evaluate the cost-effectiveness of intravenous and subcutaneous vedolizumab compared to infliximab for moderately to severely active ulcerative colitis (UC) from an Iranian societal perspective. METHODS: A decision-analytic cost-utility model was developed using a decision tree and a Markov model. Direct and indirect costs were calculated. Treatment effectiveness and …
Response to the Letter to the Editor: "AI-Assisted IBD Severity Classification: A Critical Perspective on Current Evidence and Next Steps"
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40329737 DOI: 10.1093/ibd/izaf096
No Abstract
The role of soluble CD40L in autoimmune diseases
Publication Year: 2025 Source: J Transl Autoimmun PMID: 40329996
CD40(-)CD40L is essential for immune system modulation because it coordinates both adaptive and inflammatory responses. Systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, thrombocytopenic purpura, and rheumatoid arthritis are among the autoimmune illnesses in which it is especially prominent. Thus, the CD40(-)CD40L axis is a significant therapeutic target, despite the …
Cap Polyposis Syndrome Imitating Inflammatory Bowel Disease with Polyps Extending to the Terminal Ileum
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40330084
INTRODUCTION: Cap polyposis syndrome is a rare subtype of mucosal prolapse disease characterized by erythematous, inflammatory colonic polyps covered by a cap of fibrinopurulent mucous. Although a benign condition, patients may present with significant symptoms that can be suggestive of inflammatory bowel disease or colorectal cancer. CASE PRESENTATION: We describe …
Vancomycin Therapy for Induction and Maintenance of Remission in a Patient with Refractory Ulcerative Colitis and Primary Sclerosing Cholangitis: A Case Report and Literature Review
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40330085
INTRODUCTION: Ulcerative colitis is a chronic inflammatory bowel disease that affects the colon. About 5% of ulcerative colitis patients also present with primary sclerosing cholangitis, a chronic inflammatory disease marked by cholestasis and progressive fibrosis of the bile ducts, and results in the necessity of liver transplantation. Ulcerative colitis treatment …
Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis
Publication Year: 2025 Source: FASEB Bioadv PMID: 40330433 DOI: 10.1096/fba.2025-00022
Inflammatory bowel diseases are chronic inflammatory conditions with growing prevalence in western populations. Iron is an essential component of erythrocytes hemoglobin. Under the influence of elevated hepcidin production, iron is sequestered in cells during inflammation which, in turn, leads to iron restriction for red blood cell synthesis. As a consequence, …
MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn's disease-like colitis in male mice
Publication Year: 2025 Source: Front Immunol PMID: 40330457
BACKGROUND & AIMS: Crohn's disease (CD) is a chronic inflammatory disorder primarily affecting the gastrointestinal tract. Leukocyte recruitment, M1 macrophage polarization and associated metabolic reprogramming are hallmarks of its pathomechanism. Here, we tested TE-11, a potent MIF tautomerase inhibitor (IC(50) = 5.63 mumol/dm(3)) in experimental Crohn's disease in male mice, …
Thlaspi arvense suppresses gut microbiota related TNF inflammatory pathway to alleviates ulcerative colitis
Publication Year: 2025 Source: Front Immunol PMID: 40330488
INTRODUCTION: Thlaspi arvense (TA), commonly known as "Ximi" or "Subaijiang," is a traditional Chinese medicinal herb used to prevent and treat ulcerative colitis (UC). However, the precise mechanisms underlying its therapeutic effects remain unclear, necessitating further investigation to identify potential pharmaceutical applications for UC management. This study aims to elucidate …
Current Role of Robotic Surgery in Colorectal Disease
Publication Year: 2025 Source: Visc Med PMID: 40330635
BACKGROUND: Robot-assisted surgery aims to combine the advantages of open surgery with those of minimally invasive surgery to overcome the previous limitations of laparoscopy. Compared to conventional laparoscopic methods, robot-assisted techniques offer significant advantages, which are currently increasingly employed despite mostly longer operating times and higher costs. The aim of …
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