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Surgical management of mucinous adenocarcinoma arising in perianal fistula: A case series
Publication Year: 2025 Source: Surg Open Sci PMID: 40330845
Perianal mucinous adenocarcinoma (MAC) is a rare malignancy arising in the anal canal, often associated with chronic inflammatory conditions such as perianal fistulas. This case series aims to elucidate the clinical features and surgical management of patients with perianal MAC arising from perianal fistulas. Four cases of perianal MAC are …
Biosecurity measures and effects on health performance and antibiotic use in semi-intensive broiler farms in Uganda
Publication Year: 2025 Source: One Health PMID: 40331079 DOI: 10.1016/j.onehlt.2025.101039
BACKGROUND: Effective biosecurity measures prevent the spread of pathogens, thereby reducing the need for antibiotic use on livestock farms. However, quantitative data on these practices and health outcomes in semi-intensive broiler farms in low-income settings is limited. A longitudinal study in Wakiso, Uganda, aimed to evaluate biosecurity practices, health performance, …
CD8(+) T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium
Publication Year: 2025 Source: J Inflamm Res PMID: 40331160 DOI: 10.2147/JIR.S509875
BACKGROUND: The etiology and pathogenesis of inflammatory bowel disease (IBD) are generally thought to be related to immune dysfunction and intestinal microbiota dysbiosis. However, the exact mechanisms remain unclear. METHODS: We applied a DSS-induced colitis model in wild-type and perforin-deficient (Prf1(-/-) ) mice. Adoptive transfer experiments and metabolic profiling were …
Impact of Triglyceride-Glucose Index on the Risk of Inflammatory Bowel Disease
Publication Year: 2025 Source: Zhongguo Yi Xue Ke Xue Yuan Xue Bao PMID: 40331384 DOI: 10.3881/j.issn.1000-503X.16205
Objective To investigate the impact of the triglyceride-glucose(TyG)index on the risk of inflammatory bowel disease(IBD).Methods Based on the data from UK Biobank,participants were allocated into three groups,TyG1(</=4.564),TyG2(4.564-4.808),and TyG3(>/=4.808),according to tertiles of the TyG index.Kaplan-Meier curves were established to analyze the cumulative incidence of IBD.Further,Cox proportional hazard regression was employed to …
A narrative literature review of the incidence and prevalence of safety outcomes in patients with ulcerative colitis
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40331585
INTRODUCTION: Information on rates of safety outcomes in patients with ulcerative colitis [UC] is helpful to better understand the benefit-risk profile of more recent therapies approved for UC. AREAS COVERED: This narrative review provides an updated examination of the incidence and prevalence of safety outcomes in the UC patient population. …
Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR-23a-3p-Mediated NCOA3 Expression
Publication Year: 2025 Source: Kaohsiung J Med Sci PMID: 40331881
Crohn's Disease (CD), an inflammatory bowel disorder, is influenced by genetic, immune, and environmental factors. The present study highlights the pioneering role of circular RNAs (circRNAs) in the etiology of CD, with a specific focus on hsa_circ_0005255 and its regulatory role. Utilizing both bioinformatic and experimental approaches, we exposed the …
Mesenteric Lymphatic B Cells Migrate to the Gut and Aggravate TNBS-Induced Rat Colitis via Regulating Intestinal T Cells
Publication Year: 2025 Source: Int J Mol Sci PMID: 40331987 DOI: 10.3390/ijms26083519
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is affecting a growing global population. Unlike UC, which is characterized by inflammation confined to the intestinal mucosa and submucosa, CD involves transmural inflammation of the intestine. Although the lymphatic system is believed to play a role in …
Protect Effects of Perilla Seed Extract and Its Active Ingredient Luteolin Against Inflammatory Bowel Disease Model via the PI3K/AKT Signal Pathway In Vivo and In Vitro
Publication Year: 2025 Source: Int J Mol Sci PMID: 40332054 DOI: 10.3390/ijms26083564
The purpose of this study was to investigate the anti-inflammatory effects of Perilla Seed Extract (PSE) and its active ingredient on Inflammatory Bowel Disease (IBD) in vitro and in vivo. Thirty-two C57/BL mice were randomly divided into four groups (n = 8): control group (CON), PBS group, LPS group (LPS …
Enzymes Drive Glutathione Shunt to Explain Oxidative State Using an In-Parallel Multi-Omic Method
Publication Year: 2025 Source: Int J Mol Sci PMID: 40332189 DOI: 10.3390/ijms26083632
The glutathione shunt is one of the most important contributors to the cellular redox state, with implications across cancer, chronic diseases, diseases of ageing, and autoimmune diseases, including inflammatory bowel disease (IBD). Traditionally, the redox state is gauged by the ratio of the surrogate metabolites GSH and GSSG. However, this …
Independent risk factors for diversion colitis: a retrospective case-control study
Publication Year: 2025 Source: Rev Assoc Med Bras (1992) PMID: 40332268
OBJECTIVE: The aim of this study was to investigate independent risk factors for diversion colitis induced by the surgical interruption of fecal flow in the non-functional colon. METHODS: We performed a retrospective study with 163 patients who underwent low anterior resections and created prophylactic ileostomies for rectal cancer between January …
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