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RISK FACTORS FOR RENAL CALCULI IN PATIENTS WITH CROHN'S DISEASE
Publication Year: 2025 Source: Arq Gastroenterol PMID: 40332308
BACKGROUND: The incidence of nephrolithiasis has increased significantly, diet, obesity, and high animal protein intake having been reported to be risk factors. Nephrolithiasis has a great economic impact on society related to work absenteeism, recurrent attacks of renal colic, and urological interventions. Nephrolithiasis can also progress to renal failure. It …
Effects of CB2 Receptor Modulation on Macrophage Polarization in Pediatric Inflammatory Bowel Disease
Publication Year: 2025 Source: Int J Mol Sci PMID: 40332343 DOI: 10.3390/ijms26083720
Macrophages play a crucial role in maintaining intestinal homeostasis and can exhibit either pro-inflammatory M1 or anti-inflammatory M2 phenotypes. The cannabinoid receptor type 2 (CB2) is involved in immune regulation and may represent a therapeutic target in inflammatory bowel disease (IBD). Our study investigates the phenotype of circulating macrophages and …
Circadian Rhythm Dysregulation in Inflammatory Bowel Disease: Mechanisms and Chronotherapeutic Approaches
Publication Year: 2025 Source: Int J Mol Sci PMID: 40332348 DOI: 10.3390/ijms26083724
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic intestinal inflammation. Recent research has highlighted the significant interplay between IBD pathogenesis and circadian rhythms. This review synthesizes current evidence regarding circadian regulation in IBD, covering three main areas: (1) circadian rhythms in intestinal …
Gut Microbiota Metabolites and Chronic Diseases: Interactions, Mechanisms, and Therapeutic Strategies
Publication Year: 2025 Source: Int J Mol Sci PMID: 40332366
The gut microbiota, shaped by factors such as diet, lifestyle, and genetics, plays a pivotal role in regulating host metabolism, immune function, and overall health. The diversity and balance of the gut microbiota are closely linked to the onset and progression of various chronic diseases. A growing body of evidence …
MicroRNA Sequencing of Serum Exosomes Reveals miR205-5p as an Anti-Fibrogenic Factor Against Intestinal Fibrosis in Crohn's Disease
Publication Year: 2025 Source: Int J Mol Sci PMID: 40332426
More than half of Crohn's disease patients eventually develop intestinal strictures. Intestinal fibrosis is the excessive deposition of the extracellular matrix that obstructs intestinal movement. There is no approved medication to treat intestinal stricture. The roles of serum exosomal miRNAs in intestinal fibrosis are unknown. Serum exosomal miRNA sequencing was …
Delphi Panel for the Development of Diagnostic Criteria for Metastatic Cutaneous Crohn Disease: A Consensus Statement
Publication Year: 2025 Source: JAMA Dermatol PMID: 40332924
IMPORTANCE: Metastatic cutaneous Crohn disease (MCD) is a rare condition for which there are currently no published diagnostic criteria. Formal MCD diagnostic criteria will expand clinical care and research by enabling future diagnostic code validation, crystallizing a more uniform disease entity for the purposes of translational research, and allowing the …
Long-Term Outcome of Paediatric Crohn's Disease Patients With Deep Ulcerations at Diagnosis
Publication Year: 2025 Source: Acta Paediatr PMID: 40332985 DOI: 10.1111/apa.70115
AIM: Presence of deep ulcerations (DU) at diagnosis seems to be predictive of a more severe phenotype in adult Crohn's disease (CD). The aim of our study was to investigate if the presence of DU at diagnosis was associated with a more severe disease course over time in children. METHODS: …
The Role of Blastocystis spp. in the Etiology of Gastrointestinal and Autoimmune Diseases
Publication Year: 2025 Source: Pathogens PMID: 40333047
Blastocystis spp. has been linked to gastrointestinal symptoms, yet its pathogenicity remains uncertain. In addition, the roles of virulence factors, pathogenic potential, and host-specific traits associated with symptomatic infections are still not well understood. The growing number of immunocompromised patients has contributed to an increasing prevalence of Blastocystis spp. infections, …
A Characterization of the Humoral Immune Response to Human Endogenous Retroviruses and Mycobacterium paratuberculosis in Crohn's Disease
Publication Year: 2025 Source: Pathogens PMID: 40333136
Crohn's disease (CD) is a multifactorial polygenic inflammatory bowel disease linked to aberrant immune response. Mycobacterium paratuberculosis (MAP) has been associated with CD; however, detecting MAP in CD tissues remains highly challenging. Recently, Human Endogenous Retroviruses (HERVs) differential gene expression has been reported in CD, but little is known about …
Association between inflammatory bowel disease, current therapies, and cardiovascular events: a review and meta-analysis of data from 2.2 million individuals
Publication Year: 2025 Source: J Crohns Colitis PMID: 40333172 DOI: 10.1093/ecco-jcc/jjaf078
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) is associated with increased cardiovascular (CV) risk. Advanced therapies that treat IBD may modify this risk. Our systematic review and meta-analysis aim to investigate the association between IBD, its subtypes (Crohn's disease and ulcerative colitis), and its therapies, with CV disease. METHODS: Medline, Embase, Scopus, …
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