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Benzoxanthenone Lignans Related to Carpanone, Polemanone, and Sauchinone: Natural Origin, Chemical Syntheses, and Pharmacological Properties
Publication Year: 2025 Source: Molecules PMID: 40333626
Medicinal plants from the genus Saururus are commonly used to treat inflammatory pathologies. They contain numerous bioactive compounds, notably the polycyclic lignan sauchinone from the species Saururus chinensis. An in-depth analysis of benzoxanthenone lignans related to sauchinone, and the analogous products carpanone and polemannones, has been carried out. The review …
Understanding Pouch-Related Fistulae: Don't Lose Track of Time
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40334111
No Abstract
Clinical Utility and Accuracy of Point-of-Care Testing for Anti-TNF Drug Monitoring and Loss of Response
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40334112 DOI: 10.1093/ibd/izaf101
BACKGROUND AND AIMS: Point-of-care tests (POCT) enable immediate measurement of anti-TNF blood concentrations. This study examined the association between loss of response (LOR) to infliximab (IFX) or adalimumab (ADL) and serum concentrations measured with POCT and enzyme-linked immunosorbent assay (ELISA) in inflammatory bowel disease (IBD) patients. METHODS: Patients with IBD …
Learning a deep language model for microbiomes: The power of large scale unlabeled microbiome data
Publication Year: 2025 Source: PLoS Comput Biol PMID: 40334224 DOI: 10.1371/journal.pcbi.1011353
We use open source human gut microbiome data to learn a microbial "language" model by adapting techniques from Natural Language Processing (NLP). Our microbial "language" model is trained in a self-supervised fashion (i.e., without additional external labels) to capture the interactions among different microbial taxa and the common compositional patterns …
Epiberberine ameliorates ulcerative colitis by regulating bile acids hepatoenteral circulation through intestinal FXR
Publication Year: 2025 Source: Phytomedicine PMID: 40334429
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, the development of which is accompanied by dysregulation of bile acid metabolism. Abnormal bile acid accumulation in the intestine further exacerbates intestinal inflammation in patients with UC. Coptidis Rhizoma has potential therapeutic activity against UC; however, its capacity to modulate …
Endoscopy in Inflammatory Bowel Disease: What Every Endoscopist Should Know
Publication Year: 2025 Source: Gastrointest Endosc PMID: 40334796 DOI: 10.1016/j.gie.2025.04.044
BACKGROUND AND AIMS: Endoscopic advancements have revolutionized the diagnosis, monitoring, and management of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Ileocolonoscopy remains the gold standard for initial diagnosis, guiding therapeutic strategies and providing baseline disease characterization. METHODS: The available literature was systematically reviewed, including articles …
Meta-analysis and systematic review on Sulfasalazine/5-ASA use during pregnancy: Impact on neonatal and pregnancy outcomes
Publication Year: 2025 Source: Reprod Toxicol PMID: 40334871 DOI: 10.1016/j.reprotox.2025.108939
OBJECTIVES: This study aims to evaluate the risks associated with Sulfasalazine (SSZ) and 5-aminosalicylic acid (5-ASA) use during pregnancy on perinatal outcomes in women with Inflammatory Bowel Diseases (IBD). We compared these outcomes with those of healthy pregnant women and with pregnant women with IBD not on medication. DATA SOURCES: …
Critical appraisal of the HELIOS study on surveillance in IBD patients
Publication Year: 2025 Source: Gut PMID: 40335162 DOI: 10.1136/gutjnl-2025-335446
No Abstract
Development of New Molecularly Targeted Agents in Inflammatory Bowel Disease
Publication Year: 2025 Source: Intern Med PMID: 40335305 DOI: 10.2169/internalmedicine.5410-25
Inflammatory bowel disease (IBD) is a multifactorial disorder resulting from a complex interplay among genetic predisposition, immune dysregulation, intestinal microbiota, and environmental factors. This dynamic interaction leads to aberrant immune activation within the gastrointestinal tract, ultimately leading to chronic inflammation. Recent advances in elucidating the pathophysiology of this disease have …
Real-life effectiveness and safety of tofacitinib and vedolizumab as 2nd-line for ulcerative colitis after anti-TNFs: A multicenter cohort IGIBD study (VE2TO-UC)
Publication Year: 2025 Source: Dig Liver Dis PMID: 40335332 DOI: 10.1016/j.dld.2025.04.025
BACKGROUND AND AIMS: Drug positioning in ulcerative colitis (UC) patients refractory to anti-tumor necrosis factor (TNF) is still debated. In a nationwide multicentre observational cohort, we aimed to compare the real-life effectiveness and safety of tofacitinib and vedolizumab as second-line for UC after anti-TNFs. METHODS: Disease activity was evaluated at …
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