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Novel cross-feeding human gut microbes metabolizing tryptophan to indole-3-propionate
Publication Year: 2025 Source: Gut Microbes PMID: 40336187
Tryptophan-derived indoles produced by the gut microbiota, particularly indole-3-propionate (IPA), are key compounds associated with gastrointestinal balance and overall health. Reduced levels of IPA have been associated with inflammatory bowel disease, type 2 diabetes, and colorectal cancer. Since fiber-rich diets have been shown to promote IPA, we aimed to decipher …
Intestinal biomarkers, microbiota composition, and genetic predisposition to inflammatory bowel disease as predictors of Parkinson's disease manifestation
Publication Year: 2025 Source: J Parkinsons Dis PMID: 40336252 DOI: 10.1177/1877718X251328567
BackgroundParkinson's disease (PD) is often accompanied by gastrointestinal symptoms. While elevated inflammatory biomarkers have been reported in PD patients compared to controls, the role of intestinal dysmotility and inflammation in disease manifestation is not fully understood.ObjectiveThis study sought to determine if fecal biomarkers and genetic predisposition to intestinal inflammation could …
AI-Assisted IBD Severity Classification: A Critical Perspective on Current Evidence and Next Steps
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40336258 DOI: 10.1093/ibd/izaf103
No Abstract
'We need to make "shit" sexy' a qualitative study exploring treatment adherence in adolescents with inflammatory bowel disease
Publication Year: 2025 Source: Health Psychol Behav Med PMID: 40337161 DOI: 10.1080/21642850.2025.2500323
Background: Adolescents with inflammatory bowel disease (IBD) are faced with the complexities of acquiring self-management behaviours at a time when they are also navigating developmental challenges associated with adolescence. To date, limited treatment adherence interventions exist to support adolescents with IBD. Aim: To explore the experience and support needs of …
Fatigue Is Strongly Associated with Depressive Symptoms in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40337726 DOI: 10.1159/000545572
INTRODUCTION: Fatigue is an extraintestinal manifestation in patients with inflammatory bowel disease (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), with limited information on the underlying factors. This study aimed to determine the prevalence of fatigue and associated factors in IBD patients. METHODS: This prospective observational study assessed …
Development of Satranidazole HCl-Loaded Oral Nanoparticulate Formulation for Colon Targeting and Colon Cancer Therapy Associated with Inflammatory Bowel Disease
Publication Year: 2025 Source: Curr Pharm Des PMID: 40337961 DOI: 10.2174/0113816128368738250414070421
BACKGROUND: Colon-targeted drug delivery is a crucial area of research aimed at treating local disorders like IBD, including ulcerative colitis and Crohn's disease. By delivering drugs directly to the colon, this approach enhances therapeutic efficacy and minimizes systemic toxicity. Nanoparticles are an effective vehicle for controlled drug delivery, improving treatment …
Dietary 3-aminobenzoic acid enhances intestinal barrier integrity and attenuates experimental colitis
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40338094
Disruption of intestinal epithelial integrity and increased permeability is central to the pathogenesis of ulcerative colitis (UC). In this study, we identified 3-aminobenzoic acid (3-ABA), a dietary component abundant in azuki beans, soybeans, and chickpeas as a regulator of epithelial permeability and inflammation in the colon. Screening 119 gut microbial …
Crypt abscesses, crypt distortion, and crypt rupture may help distinguish inflammatory bowel disease from segmental colitis associated with diverticulosis
Publication Year: 2025 Source: Virchows Arch PMID: 40338318 DOI: 10.1007/s00428-025-04076-8
The histologic distinction of segmental colitis associated with diverticulosis (SCAD) from inflammatory bowel disease (IBD) is difficult; however, distinguishing the two is important for patient management. This study aimed to examine histologic changes in SCAD and compare them to those in IBD. We retrospectively identified patients with highly likely SCAD …
Impact of vancomycin and Clostridioides difficile on the secretome and pathogenicity of Clostridium innocuum
Publication Year: 2025 Source: Med Microbiol Immunol PMID: 40338351 DOI: 10.1007/s00430-025-00831-5
Clostridium innocuum, a member of the human gut microbiome with intrinsic resistance to vancomycin, has been increasingly associated with inflammatory bowel diseases (IBD). Clinical observations indicate that co-infection with Clostridioides difficile and C. innocuum could lead to poorer clinical remission in ulcerative colitis; however, the pathogenic mechanism of C. innocuum …
Efficacy and safety of office-based procedures for hemorrhoidal disease in patients with inflammatory bowel disease
Publication Year: 2025 Source: Tech Coloproctol PMID: 40338393 DOI: 10.1007/s10151-025-03144-0
BACKGROUND: Hemorrhoidal disease (HD) affects 2-20% of patients with inflammatory bowel disease (IBD) but treatment recommendations are scarce due to fear of higher morbidity in these patients. Currently, there is almost no data regarding nonsurgical treatment for HD in patients with IBD. This study aimed to evaluate the safety and …
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