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Predictors of Immunogenicity and Loss of Response to ANTI-TNFα Therapy in Crohn Disease-A Systematic Review
Publication Year: 2025 Source: Am J Ther PMID: 40338684 DOI: 10.1097/MJT.0000000000001867
BACKGROUND: As the use of anti-tumor necrosis factor-alpha (TNFalpha) therapies in Crohn disease (CD) is spread, the loss-of-response (LOR) to it is increasingly encountered. Discovering a pathological pathway and biomarkers that can predict LOR would assist in the management of patients with CD. In this article, we provide a comprehensive …
Be precise, be reproducible! The emerging role of artificial intelligence in inflammatory bowel disease endoscopy
Publication Year: 2025 Source: J Crohns Colitis PMID: 40338753
No Abstract
Disparities in Access and Treatment for Rural Patients With Inflammatory Bowel Disease: A Survey of Inflammatory Bowel Disease Patients and Providers
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40339064 DOI: 10.1093/ibd/izaf090
BACKGROUND: With the increasing complexity of inflammatory bowel disease (IBD) care, the integration of IBD specialist gastroenterologists and multidisciplinary teams (MDTs) is becoming more important. However, access to these services is not widely available. This study sought to evaluate the needs of rural and urban IBD patients and providers in …
Monitoring Structural Bowel Damage in Patients With Crohn's Disease Using Intestinal Ultrasonography: Can It Be Reversed by Biological Treatment?
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40339106
BACKGROUND: Currently, medical therapy of Crohn's disease (CD) can reduce the progression of some forms of structural bowel damage (SBD), but it does not prevent it. Once SBD has developed, it is important to assess the potential of medical treatments to reverse this damage. AIMS: To determine whether transmural healing …
Crohn's Disease Stricture Response to Treatment Assessed with Magnetic Resonance Imaging and Intestinal Ultrasound: STRIDENT Randomized Trial
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40339148
BACKGROUND: Transmural healing is emerging as a key treatment target in Crohn's disease. This study aimed to determine the role of magnetic resonance imaging (MRI) and intestinal ultrasound (IUS) in the assessment of the radiologic response of Crohn's disease strictures to treatment. METHODS: The STRIDENT (Stricture Definition and Treatment) study …
Development and evaluation of immunogenicity and protective efficacy of two recombinant attenuated newcastle disease viruses expressing the VP2 protein of infectious bursal disease virus
Publication Year: 2025 Source: Poult Sci PMID: 40339237 DOI: 10.1016/j.psj.2025.105253
Newcastle disease (ND) and Infectious bursal disease (IBD) are highly contagious and economically significant viral diseases affecting poultry worldwide. Despite widespread vaccination, current vaccines often require multiple doses and provide limited protection against emerging strains. This study developed and evaluated bivalent vaccines based on recombinant Newcastle disease virus (NDV) expressing …
Polyphyllin Ⅵ modulates macrophage polarization through autophagy-NLRP3 inflammasome to alleviate inflammatory bowel disease
Publication Year: 2025 Source: Phytomedicine PMID: 40339551 DOI: 10.1016/j.phymed.2025.156640
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with a rising global prevalence. If left untreated, it can result in severe complications, including colon cancer. Key factors in IBD pathogenesis include macrophages, NOD-like receptor thermal protein domain associated protein 3 (NLRP3), and autophagy. Polyphyllin …
Ligninoformic acid improved DSS-induced chronic colitis in mice by regulating intestinal flora and intestinal barrier
Publication Year: 2025 Source: Microb Pathog PMID: 40339622 DOI: 10.1016/j.micpath.2025.107670
Inflammatory Bowel Disease (IBD) is a complex intestinal disorder that typically triggers inflammatory responses, immune dysregulation, and gut microbiota imbalance. Lignoformic acid (LFA) is a lignin-derived compound containing benzene rings and hydroxyl functional groups. It has antioxidant properties and can regulate intestinal pH. This study aimed to investigate the improve …
Construction of Mn(2+)-Polyphenol Nanoparticles and Its Application in the Treatment of Ulcerative Colitis
Publication Year: 2025 Source: ACS Appl Bio Mater PMID: 40340318
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation and ulcerative erosion of the colonic mucosa. Because of the complex causes, UC is often difficult to completely cure, greatly increasing the risk of bowel cancer and other diseases. In the UC environment, excessive production of reactive oxygen …
Association between Dietary Inflammatory Index and Ulcerative Colitis: a case-control study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40340667
INTRODUCTION: Diet plays a crucial role in the activity and onset of ulcerative colitis (UC). The aim of this study was to comprehensively explore the association between the dietary inflammatory index (DII) and UC. METHODS: Participants completed the Food Frequency Questionnaire to obtain data on their dietary intake. Individual DII …
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