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Identification of candidate biomarkers and pathways associated with vedolizumab response in T cell populations of IBD patients by WGCNA
Publication Year: 2025 Source: Cell Mol Biol (Noisy-le-grand) PMID: 40285783 DOI: 10.14715/cmb/2025.71.4.8
Vedolizumab is a monoclonal IgG1 antibody that prevents T cells from migrating to the gut mucosa. The purpose of this study was to identify key genes with promising therapeutic targets, and molecular pathways associated with vedolizumab response. Gene expression profiles of the GSE234736 dataset were downloaded from the Gene Expression …
Nano Zinc Oxide Restores Gut Barrier Integrity and Modulates Microbiota to Mitigate TNBS-Induced Colitis in Mice
Publication Year: 2025 Source: Biol Trace Elem Res PMID: 40285830 DOI: 10.1007/s12011-025-04635-9
Inflammatory bowel diseases (IBD) are chronic, relapsing gastrointestinal disorders with complex pathological mechanisms and limited treatment options, caused by various uncertain factors. Zinc plays a crucial role in wound healing, tissue regeneration, and immune responses. While zinc deficiency is common among patients with IBD, the effects of dietary zinc supplementation …
Vitamin D enhances the therapeutic effect of TNF-α antibodies through lipid metabolism in overweight IBD patients
Publication Year: 2025 Source: Cell Mol Life Sci PMID: 40285831 DOI: 10.1007/s00018-025-05626-8
The inhibitory effects of the tumor necrosis factor-alpha (TNF-alpha) antibody infliximab (IFX) on colitis are well established. Since IFX dosing is weight-based and associated with various side effects, there is a growing interest in identifying combination therapies that can enhance its efficacy, particularly in overweight inflammatory bowel disease (IBD) patients, …
Utility of rotational thrombo-elastometry as an objective measure of hypercoagulability in ulcerative colitis
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 40285983 DOI: 10.1007/s12664-025-01759-7
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) has an increased risk of venous thromboembolism (VTE), with factors such as hospitalization and surgery enhancing this risk. This study was aimed at evaluating rotational thrombo-elastometry (ROTEM) for assessing blood coagulation status in ulcerative colitis (UC) and determining its relationship with disease severity …
Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40286319
No Abstract
Integrating 16srRNA sequencing, non-targeted metabolomics, and transcriptome sequencing to explore the mechanism of Total glucosides of paeony alleviating ulcerative colitis
Publication Year: 2025 Source: J Chromatogr B Analyt Technol Biomed Life Sci PMID: 40286482
Total glucosides of paeony (TGP), an active ingredient extracted from the dried root of Paeonia lactiflora Pall., has been approved in China for the treatment of various autoimmune diseases. However, the role and mechanism of TGP in UC have yet to be fully elucidated. This study aims to investigate the …
Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice
Publication Year: 2025 Source: Cell Rep Med PMID: 40286792
This study evaluates the efficacy of the postbiotic Probio-Eco in alleviating constipation in humans and mice. A randomized, double-blind, placebo-controlled crossover trial involving 110 adults with chronic constipation (Rome IV criteria) demonstrates that a 3-week Probio-Eco intervention significantly improves constipation symptoms, stool straining, and worry scores. Gut microbiota and metabolomic …
Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study
Publication Year: 2025 Source: J Glob Antimicrob Resist PMID: 40287014 DOI: 10.1016/j.jgar.2025.04.011
OBJECTIVES: The increasing incidence of Clostridioides difficile infection (CDI) has been associated with poorer prognosis of patients with inflammatory bowel disease (IBD). However, relevant data are limited in China. The aim of this study was to clarify the molecular types and clinical characteristics of C. difficile in IBD patients in …
Human Milk Oligosaccharides Modulating Inflammation in Infants, Adults, and Older Individuals-From Concepts to Applications
Publication Year: 2025 Source: Adv Nutr PMID: 40287068
The increasing global prevalence of inflammatory diseases, such as ulcerative colitis and irritable bowel syndrome, represents a challenging task for healthcare systems. Several approaches to disease management target the intestinal microbiome, which plays a key role in health and disease. One promising approach is modulating the microbiome using human milk …
Vinegar-processed frankincense ameliorates ulcerative colitis by targeting BSH-active bacteria preference-mediated GDCA hydrolysis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40287117
ETHNOPHARMACOLOGICAL RELEVANCE: Frankincense, is extensively used in both traditional Chinese medicine (TCM) and Indian practices for the treatment of ulcerative colitis (UC). In TCM, it is typically subjected to process with vinegar, which is believed to enhance its therapeutic efficacy. However, the underlying mechanism has yet to be elucidated. AIM …
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