Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Non-Infectious Complications of Chronic Granulomatous Disease: Knowledge Gaps & Novel Treatment Considerations
Publication Year: 2025 Source: Immunol Allergy Clin North Am PMID: 40287173
Chronic granulomatous disease (CGD) is a rare primary phagocytic immunodeficiency characterized by recurrent infections due to impaired NADPH oxidase activity. Balancing the need for additional immune suppression with the risk of infection in patients with CGD-associated inflammation can be difficult but increased understanding of the underlying pathophysiology may allow for …
Comment on "Exacerbated gastrointestinal symptoms and long COVID in IBD patients with SARS-CoV-2 infection: A multi-center study from Taiwan"
Publication Year: 2025 Source: J Formos Med Assoc PMID: 40287369 DOI: 10.1016/j.jfma.2025.04.029
No Abstract
Use of cellular free nucleic acids for diagnosis and treatment of inflammatory bowel disease
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40287782
No Abstract
Intestinal metabolites in colitis-associated carcinogenesis: Building a bridge between host and microbiome
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40287783
Microbial-derived metabolites are important mediators of host-microbial interactions. In recent years, the role of intestinal microbial metabolites in colorectal cancer has attracted considerable attention. These metabolites, which can be derived from bacterial metabolism of dietary substrates, modification of host molecules such as bile acids, or directly from bacteria, strongly influence …
Neutrophils disrupt the intestinal barrier via IL-22/TGF-β/Mmp9 axis in the zebrafish model of inflammatory bowel disease
Publication Year: 2025 Source: J Genet Genomics PMID: 40288520
No Abstract
Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition
Publication Year: 2025 Source: J Adv Res PMID: 40288675 DOI: 10.1016/j.jare.2025.04.030
INTRODUCTION: Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1 (DEL-1), a natural modulator of tissue immunity and inflammation resolution, has not been studied in IBD. OBJECTIVES: We aimed to investigate the expression and …
Colon-targeted complement C5a(1) receptor inhibition using pH-sensitive nanoparticles ameliorates experimental colitis
Publication Year: 2025 Source: Br J Pharmacol PMID: 40288760 DOI: 10.1111/bph.70056
BACKGROUND AND PURPOSE: The complement system is associated with inflammatory bowel disease (IBD) pathology. Complement activation induces C5a production, which signals through the C5a(1) receptor (C5aR1) to drive inflammatory responses that may underlie IBD. EXPERIMENTAL APPROACH: We examined mucosal biopsies from ulcerative colitis patients and identified C5a(1) receptor up-regulated in …
Impact of GLP- 1 Receptor Agonist Therapy in Patients High Risk for Sarcopenia
Publication Year: 2025 Source: Curr Nutr Rep PMID: 40289060
PURPOSE OF REVIEW: Glucagon-like peptide- 1 receptor agonists (GLP- 1 RA) are a rapidly expanding class of medications used to treat many chronic diseases. This review explores factors that may contribute to accelerated muscle loss among higher-risk patient populations and describes tailored interventions to reduce the risk of accelerated sarcopenia …
Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner
Publication Year: 2025 Source: Sci Rep PMID: 40289168
Although toxicity of alcohol toward the intestines and immunity is mentioned, there might be different effect of alcohol in a low and a high dose and the rodent model development using a simple SHIRPA binary score night be useful. Hence, a low and high dose of alcohol (6.30 and 1.26 …
High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation
Publication Year: 2025 Source: Gut Microbes PMID: 40289251 DOI: 10.1080/19490976.2025.2489071
BACKGROUND: Coeliac disease (CeD) is an immune-mediated disorder primarily affecting the small intestine, characterized by an inflammatory immune reaction to dietary gluten. CeD onset results from a multifaceted interplay of genetic and environmental factors. While recent data show that alterations in gut microbiome composition could play an important role, many …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide