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Fatigue in Inflammatory Bowel Disease: No Effect of Serum Concentrations of Infliximab, Adalimumab or Anti-Drug Antibodies During Maintenance Therapy
Publication Year: 2025 Source: Scand J Immunol PMID: 40289444
Several studies have shown that infliximab and adalimumab ameliorate fatigue in inflammatory bowel disease. We investigated whether serum levels of these agents above or below a selected threshold influence fatigue severity. In this cross-sectional study, we measured serum concentrations (s-) of infliximab and adalimumab and corresponding anti-drug antibody levels. Therapeutic …
Serum regenerative islet-derived protein 1α: a novel and sensitive biomarker for endoscopic disease activity in ulcerative colitis
Publication Year: 2025 Source: Ann Med PMID: 40289639 DOI: 10.1080/07853890.2025.2496404
INTRODUCTION: Mucosal healing (MH) has established as a long-term therapeutic goal for inflammatory bowel disease (IBD). Regenerative Islet-derived Protein 1alpha (reg1alpha) was reported to be closely related to gastrointestinal mucosal injury; however, its potential in monitoring MH remains unexplored. METHODS: Serum reg1alpha levels were quantified in 156 consecutive IBD patients …
A multicenter study of the real-world effectiveness and safety of risankizumab in Crohn's disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40289770
BACKGROUND: We aimed to evaluate the effectiveness and safety of risankizumab (RZB) for Crohn's disease (CD) in routine clinical practice. METHODS: We performed a retrospective review of a multicenter consortium of CD patients treated with RZB. Co-primary outcomes were week 12 clinical remission (Harvey Bradshaw Index [HBI] score of </=4 …
A Low Dietary Quality Index in a Newly Diagnosed Inflammatory Bowel Disease Cohort: Results from a Case-Control Study
Publication Year: 2025 Source: Nutrients PMID: 40289961 DOI: 10.3390/nu17060958
BACKGROUND: Epidemiological evidence suggests a link between the risk of IBD and diet. Macro- and micro- nutrient intake, diet quality and dietary patterns may play a pivotal role in disease pathogenesis. We aimed to study the dietary intake of newly diagnosed IBD patients compared to non-IBD controls. METHODS: A cohort …
Lacticaseibacillus casei IDCC 3451 alleviates cognitive and behavioral functions by reshaping the gut microbiome and regulating intestinal barrier integrity in chronic stress animal models
Publication Year: 2025 Source: Curr Res Food Sci PMID: 40290371 DOI: 10.1016/j.crfs.2025.101051
Lacticaseibacillus casei IDCC 3451 (3451) was evaluated for its effects on the gut-brain axis using Caenorhabditis elegans (C. elegans) and mouse models of stress and inflammation. In C. elegans, 3451 extended lifespans by 25 %, improved motility, and chemotaxis, enhanced survival under pathogen challenge, and reduced amyloid beta accumulation by …
High pathogenicity of emerging porcine G9P[23] and G11P[7] rotavirus for newborn piglets in China
Publication Year: 2025 Source: Front Vet Sci PMID: 40290474
In order to better understand the pathogenicity of the current porcine A group rotavirus (PoRVA) field strains, AHBZ2304 (G9P[23]) and AHBZ2303 (G11P[7]) isolated from diarrhea suckling piglets were selected for pathogenicity analysis in the present study. Experimental inoculation of colostrum-deprived 2-day-old piglets revealed that both isolates caused severe clinical sings, …
Effectiveness of Bioenergy Economy-based Health Improvement (BEHI) versus Acceptance and Commitment Therapy (ACT) on the Psychological Comorbidities and Quality of Life in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40290580 DOI: 10.1093/crocol/otaf018
BACKGROUND: Inflammatory IBD has a significant adverse influence on the physical, psychological, family, and social dimensions of patients. This research aims to compare the effectiveness of ACT and BEHI on perceived stress, quality of life, sense of coherence, and D personality type in patients with IBD. METHODS: This study used …
From Food Fears to Food Freedom: How Do We Best Manage Restrictive Eating in Inflammatory Bowel Disease?
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40290581 DOI: 10.1093/crocol/otaf019
Prior research has estimated the rates of avoidant/restrictive food intake disorder (ARFID) to be between 10% and 54% in patients with inflammatory bowel disease (IBD). However, recently published studies have questioned the ability of providers to differentiate the presence of ARFID in patients with gastrointestinal (GI) symptoms and highlighted the …
Assessing endoscopic remission in small bowel Crohn's disease: Are markers enough?
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40291128
Mucosal healing in Crohn's disease (CD) has been established as a crucial target of treatment, leading to long term remission and decrease in complication rates. Endoscopy still serves as the gold standard for assessment, particularly in the small bowel where balloon or capsule enteroscopy is frequently needed. However, these modalities …
Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn's disease: A critical review and the path forward
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40291129
The study by Ohno et al provides valuable insights into the role of leucine-rich alpha-2-glycoprotein (LRG) as a potential biomarker for identifying small bowel lesions in Crohn's disease (CD). However, several methodological challenges hinder its immediate use in clinical practice. Notably, the current research was retrospective, lacks comparative studies with …
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