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Idiopathic Myointimal Hyperplasia of the Mesenteric Veins: A Rare Mimic of Inflammatory Bowel Disease
Publication Year: 2025 Source: Cureus PMID: 40291180
Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare cause of segmental intestinal ischemia. It is usually associated with chronic symptoms of abdominal pain, diarrhea, and rectal bleeding, but it also can present in more acute and dramatic clinical presentations. Surgical segmental bowel resection is the proper treatment, …
Identification and Experimental Validation of PANoptosis-Related Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics Analysis
Publication Year: 2025 Source: J Inflamm Res PMID: 40291456
AIM: To identify the molecular signature of differentially expressed genes (DEGs) associated with PANoptosis in idiopathic pulmonary fibrosis (IPF) and to interpret their immune landscape and cellular distribution characteristics. METHODS AND RESULTS: We acquired two IPF datasets from the Gene Expression Omnibus (GEO) database to identify PANoptosis-related DGEs (PAN-DEGs), initially …
Endoscopic gas leak in diverted colon mimics perforation
Publication Year: 2025 Source: Gastroenterol Rep (Oxf) PMID: 40291486 DOI: 10.1093/gastro/goaf033
No Abstract
Longitudinal Outcomes of Abdominoperineal Resection Reconstruction: A Single-center Retrospective Review
Publication Year: 2025 Source: Plast Reconstr Surg Glob Open PMID: 40291639
BACKGROUND: Reconstruction after abdominoperineal resection (APR) typically utilizes primary closure, locoregional myocutaneous flaps (gracilis or vertical rectus myocutaneous [VRAM]), or omental flaps. Although flap coverage is considered superior to primary closure, no specific flap is preferred, and reconstructive complications can occur in 20%-50% patients. The purpose of this study was …
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases
Publication Year: 2025 Source: bioRxiv PMID: 40291692 DOI: 10.1101/2025.03.26.645544
Multi-omic and multimodal datasets with detailed clinical annotations offer significant potential to advance our understanding of inflammatory bowel diseases (IBD), refine diagnostics, and enable personalized therapeutic strategies. In this multi-cohort study, we performed an extensive multi-omic and multimodal analysis of 1,002 clinically annotated patients with IBD and non-IBD controls, incorporating …
Association of Clostridium difficile infection with clinical outcomes of patients with inflammatory bowel disease: A meta-analysis
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40291861 DOI: 10.4240/wjgs.v17.i4.100555
BACKGROUND: Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD). AIM: To assess the association of CDI with clinical outcomes of IBD. METHODS: PubMed, EMBASE, Web of Science, and the Cochrane Library databases were searched from inception to March 2024. Eligible articles included observational studies that …
Challenges of concurrent HIV infection in the course and management of Crohn's disease
Publication Year: 2025 Source: J Med Life PMID: 40291934 DOI: 10.25122/jml-2024-0359
Crohn's disease (CD) is a chronic transmural bowel inflammation with a multifactorial etiology involving genetic predisposition and immune dysregulation in response to environmental triggers. In patients with human immunodeficiency virus (HIV), an already compromised immune system further complicates the progression and management of CD, creating unique therapeutic challenges. Probiotics have …
Gut microbiota and intestinal immunity interaction in ulcerative colitis and its application in treatment
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40292216
Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease characterized by inflammation and injury of the colonic mucosa, exhibiting an increasing global incidence. Although research into UC pathogenesis is ongoing, the precise mechanisms remain to be fully elucidated. Studies indicate that UC development results from a complex interplay of …
Protective effects of Indigofera argentea against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators
Publication Year: 2025 Source: Avicenna J Phytomed PMID: 40292264 DOI: 10.22038/AJP.2024.24977
OBJECTIVE: The plant Indigofera argentea Burm. f., belonging to the family Fabaceae, is locally known as Hathio, Jantar and Neel. This plant is commonly found in deserted habitat and used traditionally to treat inflammatory and gastric disorders. The current study was designed to evaluate the phytochemical profile, toxicity and intestinal …
Corrigendum: Is a rare CXCL8 gene variant a new possible cause or course factor of inflammatory bowel disease?
Publication Year: 2025 Source: Front Immunol PMID: 40292301 DOI: 10.3389/fimmu.2025.1599125
[This corrects the article DOI: 10.3389/fimmu.2025.1562618.].
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