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Non-Cystic Fibrosis Bronchiectasis in Adults: A Review
Publication Year: 2025 Source: JAMA PMID: 40293759
IMPORTANCE: Non-cystic fibrosis (CF) bronchiectasis is a chronic lung condition caused by permanent bronchial dilatation and inflammation and is characterized by daily cough, sputum, and recurrent exacerbations. Approximately 500 000 people in the US have non-CF bronchiectasis. OBSERVATIONS: Non-CF bronchiectasis may be associated with prior pneumonia, infection with nontuberculous mycobacteria …
Laminarin-mediated oral delivery of miRNA-223 for targeted macrophage polarization in inflammatory bowel disease
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40294678
Intestinal inflammatory disorders, such as ulcerative colitis, are driven by excessive pro-inflammatory M1 macrophages, leading to tissue damage and chronic inflammation. MicroRNA-223 (miRNA-223) presents a promising therapeutic approach by shifting macrophage polarization from the M1 to the anti-inflammatory M2 phenotype, thereby reducing inflammation. However, oral delivery of miRNA-223 is hindered …
Diminution of HSP75 disrupts intestinal epithelial barrier by inciting mPTP opening in ulcerative colitis
Publication Year: 2025 Source: Cell Signal PMID: 40294832
Ulcerative colitis is an idiopathic, chronic inflammatory disorder. The disruption of intestinal epithelial barrier caused by excessive apoptosis of intestinal epithelial cells is a pivotal factor in the etiology and pathology. The mitochondrial pathway is the most significant apoptosis mode of intestinal epithelial cells, which was regulated by the mitochondrial …
[Moslosooflavone ameliorates dextran sulfate sodium-induced colitis in mice by suppressing intestinal epithelium apoptosis via inhibiting the PI3K/AKT signaling pathway]
Publication Year: 2025 Source: Nan Fang Yi Ke Da Xue Xue Bao PMID: 40294932
OBJECTIVES: To investigate the effect of moslosooflavone (MOS) for ameliorating dextran sulfate sodium (DSS)-induced colitis in mice and the underlying molecular mechanism. METHODS: C57BL/6J mice with or without DSS exposure in the drinking water were both randomized into two groups for treatment with intraperitoneal injections with MOS (200 mg/kg) or …
Neutrophil-to-Lymphocyte Ratio as a Biomarker for Postoperative Complications in Crohn's Disease
Publication Year: 2025 Source: In Vivo PMID: 40295000
BACKGROUND/AIM: Despite advances in diagnosis and pharmacotherapy, surgery remains crucial for Crohn's disease (CD). Postoperative intra-abdominal septic complications (IASC) occur in 1.2-16.7% of cases. We investigated the frequency of postoperative IASC in elective surgeries for CD and the risk factors and potential biomarkers for postoperative IASC. PATIENTS AND METHODS: We …
IgA Nephropathy Associated With Infliximab Treatment in Patients With Crohn's Disease: Study of IgA1 and IgA2 Expression in Glomeruli
Publication Year: 2025 Source: In Vivo PMID: 40295023
BACKGROUND/AIM: It is well known that infliximab is an anti-tumor necrosis factor chimeric factor that is effective in treating inflammatory bowel diseases, such as Crohn's disease. Recently, there have been reports of new onset or flare-ups of immunoglobulin A (IgA) nephropathy during infliximab therapy for Crohn's disease. Inflammatory bowel disease-associated …
Appendectomy Mitigates Ulcerative Colitis Activity and Delays Colorectal Cancer Onset: A Retrospective Cohort Study
Publication Year: 2025 Source: Anticancer Res PMID: 40295040
BACKGROUND/AIM: Ulcerative colitis (UC) is an idiopathic inflammatory disease with rising global incidence, influenced by genetic, environmental, and immunological factors whose interactions remain unclear. Although the appendix appears to influence UC onset and disease activity, few studies have investigated how the timing of appendectomy affects disease activity and colorectal cancer …
Expert recommendations to standardize transcriptomic analysis in inflammatory bowel disease clinical trials
Publication Year: 2025 Source: J Crohns Colitis PMID: 40295219 DOI: 10.1093/ecco-jcc/jjaf068
BACKGROUND AND AIMS: Substantial methodological and reporting heterogeneity confounds the interpretation and generalizability of transcriptomic data for inflammatory bowel disease (IBD) studies. We aimed to develop recommendations to standardize transcriptomic research in clinical trials. METHODS: A 2-part study was undertaken. A systematic review identified reports of transcriptomic analyses utilizing samples …
Efficacy and safety of mirikizumab in the treatment of inflammatory bowel disease: A meta-analysis
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40295305 DOI: 10.1097/MD.0000000000042123
BACKGROUND: This meta-analysis explores the efficacy and safety of mirikizumab in treating IBD. METHODS: A comprehensive search was conducted encompassing randomized controlled trials examining the efficacy of mirikizumab in treating IBD across PubMed, Embase, Cochrane Library, and Web of Science, with a search deadline of November 1, 2023. Quality assessment …
Efficacy of curcumin supplementation for the treatment and prevention of pouchitis after ileal pouch-anal anastomosis: a randomized controlled trial
Publication Year: 2025 Source: Eur J Nutr PMID: 40295333
BACKGROUND: Pouchitis is the most common complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis. Induction and maintenance of remission is a crucial therapeutic goal. We investigated curcumin's efficacy in treatment of pouchitis. METHODS: The double-blind trial included an induction cohort of refractory pouchitis patients and a maintenance cohort of …
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