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The role of fecal microbiota transplantation on the NLRP3-Caspase 1 pathway and anxiety like behavioral in the ulcerative colitis model in rats
Publication Year: 2025 Source: Sci Rep PMID: 40295607
The purpose of this study was to investigate the function of the NLRP3-Caspase 1 signaling pathway in the colon during fecal microbiota transplantation (FMT) in colitis induced by acetic acid. Additionally, the study aimed to determine the impact of FMT on anxiety behaviors by analyzing the function of the NLRP3-Caspase …
Gut microbiomes and treatment-resistant ulcerative colitis: a case-control study using qPCR
Publication Year: 2025 Source: BMC Microbiol PMID: 40295906
BACKGROUND: The gut microbiome has been identified as a pivotal factor in ulcerative colitis (UC), given its role as the main reservoir of microbes in the body. This community of microorganisms, present in variable concentrations in the digestive tract, makes a wide range of beneficial roles for the host. However, …
Analysis of causal effects on metabolic syndrome and inflammatory bowel disease: a Mendelian randomization study
Publication Year: 2025 Source: Diabetol Metab Syndr PMID: 40296126 DOI: 10.1186/s13098-025-01704-w
BACKGROUND: Metabolic syndrome (MetS) is a conglomerate of metabolic abnormalities including hypertension, obesity, hyperglycemia, hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol (HDL-C). The relationship between MetS and Inflammatory Bowel Disease (IBD) has received a lot of attention lately. Epidemiological investigation has yet to determine if the two illnesses are …
Use of Human In Vitro Gut Specimens for Translational Neurogastroenterology and Motility in the 21st Century
Publication Year: 2025 Source: Neurogastroenterol Motil PMID: 40296281 DOI: 10.1111/nmo.15022
There is a huge gap in our understanding of the human ENS and translating data from mice to humans that is important when developing targeted therapeutics. The ENS or "human little brain in the gut" is easily accessible for study in GI surgical or biopsy samples. This mini review is …
Biofeedback-Enhanced Cognitive-Behavioral Therapy Delivered Virtually to Youth With Inflammatory Bowel Disease: A Randomized Controlled Trial
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40296354 DOI: 10.1093/ibd/izaf061
BACKGROUND: Inflammatory bowel diseases (IBDs) are increasingly recognized as products of the brain-gut axis associated with dysfunctions of the chronic stress response systems. The objectives of this study were to evaluate the feasibility, acceptability, and preliminary efficacy of a virtual, group-based heart rate variability (HRV) biofeedback-enhanced coping skills intervention for …
Diagnosing the Overlap: Metastatic Crohn's Disease With Hidradenitis Suppurativa-Like Features
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40296356
No Abstract
Reply: Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40296357
No Abstract
Not All Transmural Healing is Equal in Crohn's Disease: Magnetic Resonance Enterography and Intestinal Ultrasound for Stricture Assessment in the STRIDENT Trial
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40296365
No Abstract
The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40296371 DOI: 10.1093/ibd/izaf053
BACKGROUND: The fecal microbiome of patients with inflammatory bowel diseases (IBD) is characterized by longitudinal variability. It remains unknown if this is caused by decreased resilience of the microbiome to external factors. We investigated the influence of osmotic diarrhea induced by bowel preparation as a disruptive factor on the fecal …
Strategies for Developing Activity-Based Luminescent Probes for Imaging and Diagnosing Inflammatory Bowel Diseases
Publication Year: 2025 Source: Chemistry PMID: 40296432 DOI: 10.1002/chem.202500872
Inflammatory bowel diseases (IBD) have experienced a concerning global increase in incidence over recent decades. The advent of molecular imaging probes has revolutionized real-time biomarker monitoring in IBD pathophysiology, enabling visualization of critical pathological processes. These probes provide dynamic insights into oxidative stress mediators (including reactive oxygen species and reactive …
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