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Defining normal bowel wall thickness in children with inflammatory bowel disease in deep remission: A multicenter study on behalf of the pediatric committee of the International Bowel Ultrasound Group (IBUS)
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40296563 DOI: 10.1002/jpn3.70049
OBJECTIVES: Intestinal ultrasound (IUS) is a noninvasive tool for detecting and monitoring disease activity in children with inflammatory bowel disease (IBD). Remission values for bowel wall thickness (BWT) are extrapolated from adult data. We aimed to define normal BWT in children with IBD in sustained deep remission. METHODS: Multicenter, retrospective …
Prevalence and predictors of low bone mineral density in pediatric inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40296588 DOI: 10.1002/jpn3.70047
OBJECTIVES: Bone health is at risk in children with inflammatory bowel disease (IBD). This study examined the prevalence and predictors of low bone mineral density (BMD) in a cohort of children and young adults with IBD. METHODS: This single-center retrospective study included patients with IBD, ages 3.5-22 years, with completed …
Small Intestinal Bacterial Overgrowth (SIBO) - Prevention and Therapeutic Role of Nutrition, Prebiotics, Probiotics, and Prokinetics
Publication Year: 2025 Source: Curr Pharm Des PMID: 40296627
Small Intestinal Bacterial Overgrowth (SIBO) is a condition marked by an increased proliferation of bacteria in the small intestine. This leads to a range of GI symptoms and nutritional issues. This article examines the preventive and therapeutic roles of nutrition, prebiotics, probiotics, and prokinetics in managing SIBO. Finding the prevalence …
Exploring brain dysfunction in IBD: A study of EEG-fMRI source imaging based on empirical mode diagram decomposition
Publication Year: 2025 Source: Math Biosci Eng PMID: 40296799 DOI: 10.3934/mbe.2025035
Patients with inflammatory bowel disease (IBD) often suffer from mood disorders and cognitive decline, which has prompted research into abnormalities in emotional brain regions and their functional analysis. However, most IBD studies only focus on single-modality neuroimaging technologies. Due to a limited spatiotemporal resolution, it is unfeasible to fully explore …
Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease
Publication Year: 2025 Source: Front Pharmacol PMID: 40297136 DOI: 10.3389/fphar.2025.1545392
BACKGROUND: Pediatric inflammatory bowel disease (IBD), especially Crohn's disease, significantly affects gut health and quality of life. Although gut microbiome research has advanced, identifying reliable biomarkers remains difficult due to microbial complexity. METHODS: We used RNA-seq-based microbial profiling and machine learning (ML) to find robust biomarkers in pediatric IBD. Microbial …
Comparative efficacy of subcutaneous infliximab switching in remission and non-remission patients with inflammatory bowel disease after intravenous maintenance: 1-year outcome from a multicentre cohort study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40297201 DOI: 10.1177/17562848251333516
BACKGROUND: Elective switching from intravenous (IV) to subcutaneous (SC) infliximab (IFX) has shown efficacy in patients with inflammatory bowel disease (IBD). However, long-term outcomes for patients not in remission remain unclear. OBJECTIVES: We evaluated the effectiveness of SC IFX switching in both remission and non-remission patients. DESIGN: This study was …
Switch acceptance and persistence of adalimumab biosimilars in IBD patients: a prospective observational study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40297206 DOI: 10.1177/17562848251332025
BACKGROUND: Prospective data about the acceptance and outcomes of switching from the adalimumab (ADA) reference product (RP) to multiple ADA biosimilars in inflammatory bowel disease (IBD) patients are lacking. OBJECTIVES: To evaluate the acceptance rate of switching from the ADA RP to ADA biosimilars, identify factors associated with non-acceptance, assess …
Comment on "Effectiveness and safety of oral vancomycin for the treatment of inflammatory bowel disease associated with primary sclerosing cholangitis: a systematic review and pooled analysis"
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40297210
No Abstract
Regional Trends in Inflammatory Bowel Disease-Related Mortality in the US from 1999 to 2022
Publication Year: 2025 Source: Clin Exp Gastroenterol PMID: 40297243 DOI: 10.2147/CEG.S513012
PURPOSE: Inflammatory bowel disease (IBD) is a grouping of chronic inflammatory diseases of the gastrointestinal tract that affects upwards of 2.4 million Americans. Despite its prevalence, the exact cause remains unknown. This study aims to identify geographical differences in IBD-related mortality. PATIENTS AND METHODS: We utilized Centers for Disease Control …
Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
Publication Year: 2025 Source: MedComm (2020) PMID: 40297245
Molecular hydrogen (H(2)), recognized as the smallest gas molecule, is capable of permeating cellular membranes and diffusing throughout the body. Due to its high bioavailability, H(2) is considered a therapeutic gas for the treatment of various diseases. The therapeutic efficacy of hydrogen is contingent upon factors such as the administration …
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