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Sex Differences in Colonic Inflammation are Driven by Epithelial-Specific Expression of Estrogen Receptor Alpha
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40297530
BACKGROUND AND AIMS: Inflammatory bowel disease patients exhibit altered expression of nuclear estrogen receptors alpha and beta (ERalpha and ERbeta) and G-protein coupled estrogen receptor 1 (GPER1). We previously showed that deletion of ERalpha protects against intestinal damage selectively in female mice; however, the mechanisms conferring sex-specific protection are poorly …
A Not-So-Sweet Crohn's Disease: A Case Report of Ileocecal Crohn's Disease Unmasked by Sweet Syndrome
Publication Year: 2025 Source: Case Rep Med PMID: 40297562 DOI: 10.1155/carm/6680526
Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis characterized by a constellation of clinical symptoms and histologic findings: pyrexia, neutrophilia, and tender and erythematous cutaneous lesions (plaques, nodules, and papules) with neutrophilic infiltration of the upper reticular dermis. SS can be either an inflammatory disease or a hypersensitivity disorder. …
Subtractive proteomics and reverse-vaccinology approaches for novel drug targets and designing a chimeric vaccine against Ruminococcus gnavus strain RJX1120
Publication Year: 2025 Source: Front Immunol PMID: 40297578 DOI: 10.3389/fimmu.2025.1555741
Mediterraneibacter gnavus, also known as Ruminococcus gnavus, is a Gram-positive anaerobic bacterium that resides in the human gut microbiota. Notably, this bacterium plays dual roles in health and disease. On one side it supports nutrient metabolism essential for bodily functions and on the other it contributes to the development of …
Metabolomics and network pharmacology reveal the anti-inflammatory core substances and mechanisms of a new cultivar of high-polyphenol lettuce
Publication Year: 2025 Source: J Sci Food Agric PMID: 40298069
BACKGROUND: Diet plays a significant role in mitigating inflammation, with lettuce and its polyphenols showing potential for improving inflammatory conditions. However, research on the material basis and mechanisms of action remains unclear. RESULTS: This study investigated the primary components and anti-inflammatory effects of the new lettuce cultivar Binfen-1, which is …
Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40298092 DOI: 10.1111/apt.70162
BACKGROUND: Inflammatory bowel diseases (IBD) have been associated with an increased long-term risk of coronary artery disease due to chronic systemic inflammation. AIM: To evaluate the risk of major adverse cardiovascular events (MACE) after coronary interventions. METHODS: In this nationwide cohort study of adults undergoing percutaneous coronary intervention (PCI) or …
The multifaceted role of sirtuins in inflammatory bowel diseases
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40298096 DOI: 10.1152/ajpgi.00311.2024
Inflammatory bowel diseases (IBDs), mainly involving the disease states of ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic, relapsing inflammation of the gastrointestinal tract. IBD has an unclear etiology and likely develops from a complex interaction between the host's genetic predisposition, the gut microbiota, the immune system, …
Parkinson Disease and the Gut: A Primer for Gastroenterologists
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40298214
Parkinson disease (PD) is a chronic, progressive movement disorder and the fastest growing neurological condition worldwide, affecting over 6 million individuals. In 2017, the economic burden of PD in the United States alone reached $52 billion. Gastrointestinal symptoms and dysfunction such as constipation, gastroparesis, and dysphagia are common in PD, …
Role of Endoscopy in Inflammatory Bowel Disease: What Every Gastroenterologist Should Know
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40298226 DOI: 10.14309/ajg.0000000000003507
Endoscopy plays a pivotal role in managing inflammatory bowel disease (IBD). The role of endoscopy has evolved over the years, from diagnostic to surveillance to now doing therapeutic procedures to manage patients with IBD. From the initial diagnostic endoscopy, describing the extent and severity of the disease is an essential …
Beta-Sitosterol-Conjugated Sinapic Acid-Engineered Nanoliposome: Biomucoadhesive and Enzyme-Responsive Targeted Oral Therapy in Ulcerative Colitis
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40298241
Developing oral drug delivery systems is promising for ulcerative colitis (UC). However, the key challenges, including formulation degradation under harsh gastric conditions, poor targeting efficiency, and limited colonic residence, lead to poor therapeutic efficacy that still needs to be tackled. Effective treatment requires a safe, efficacious, enzyme- and pH-responsive, biomucoadhesive …
Case 340
Publication Year: 2025 Source: Radiology PMID: 40298599
A 36-year-old woman with an otherwise unremarkable medical history was diagnosed with moderate to severe Crohn disease and was started on infliximab. One year later, infliximab was discontinued due to intolerance, and the patient began azathioprine and mesalazine treatment, achieving stable disease. Eight months after discontinuing infliximab, during a Crohn …
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