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Probiotic Lactobacillus johnsonii Reduces Intestinal Inflammation and Rebalances Splenic Treg/Th17 Responses in Dextran Sulfate Sodium-Induced Colitis
Publication Year: 2025 Source: Antioxidants (Basel) PMID: 40298818 DOI: 10.3390/antiox14040433
Inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gastrointestinal tract, is frequently complicated by extraintestinal manifestations such as functional hyposplenism. Increasing evidence highlights its pathogenesis as a multifactorial interplay of gut dysbiosis, intestinal barrier dysfunction, and dysregulated immune responses. While probiotics, particularly Lactobacillus spp., have emerged as potential …
A Diet Fortified with Anthocyanin-Rich Extract (RED) Reduces Ileal Inflammation in a Senescence-Prone Mice Model of Crohn's-Disease-like Ileitis
Publication Year: 2025 Source: Antioxidants (Basel) PMID: 40298846 DOI: 10.3390/antiox14040473
SAMP mice develop progressive Crohn's disease (CD)-like ileitis without spontaneous colitis that worsens over time without chemical, genetic, or immunological manipulation. Even growing in an identical vivarium and fed with the same diet, SAMP mice reveal a distinct fecal microbiome, metabolome, and lipidome profile compared to AKR mice, their non-inflamed …
Bioinspired Claw-Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40298904
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by focal iron overload. Herein, we reported that gamma-glutamylcysteine (gammaGC) deletion in UC lesions intensified the disease by depleting intracellular GSH to induce macrophage ferroptosis, leading to macrophage M1 reprogramming and eventually exacerbating inflammation. To counteract this, the advanced microparticles …
Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal Organoids
Publication Year: 2025 Source: Stem Cell Rev Rep PMID: 40299197 DOI: 10.1007/s12015-025-10887-8
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a multifactorial, immune-mediated condition marked by chronic gastrointestinal inflammation. This condition significantly impairs patients' quality of life and represents a major public health challenge globally. Pathogenesis of IBD arises from complex interplay among genetic predisposition, environmental factors, …
Adipokine Profiles and Their Association with Body Composition and Disease Activity in Pediatric Crohn's Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40299289 DOI: 10.1007/s10620-025-08941-z
OBJECTIVES: Emerging evidence implicates an important role for visceral fat, particularly "creeping fat," in the pathogeneses and progression of inflammatory bowel diseases (IBD), specifically Crohn's disease (CD). In this study, we aimed to explore the association between body composition, adipocytokine profiles, and disease activity in pediatric CD patients. METHODS: We …
Annual Therapeutic Drug Monitoring in Patients with Inflammatory Bowel Disease During Infliximab Maintenance Therapy: Balancing Efficacy with Risk of Pharmacokinetic Failure
Publication Year: 2025 Source: Dig Dis Sci PMID: 40299290 DOI: 10.1007/s10620-025-09032-9
BACKGROUND AND AIMS: Recent studies indicate that proactive therapeutic drug monitoring (TDM) can improve clinical outcomes in patients with inflammatory bowel disease (IBD) treated with infliximab. Repetitive infliximab trough level (IFX TL) measurements for proactive TDM may increase patient inconvenience and medical costs. Therefore, we aimed to determine the optimal …
Graying of IBD in the US-An Urgent Call to Action
Publication Year: 2025 Source: Dig Dis Sci PMID: 40299291 DOI: 10.1007/s10620-025-09082-z
No Abstract
Frailty Prevalence and Evaluation of the FRAIL Scale Questionnaire in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40299292 DOI: 10.1007/s10620-025-09073-0
BACKGROUND: Inflammatory bowel disease (IBD) predisposes individuals to frailty, linked with adverse outcomes. While the Fried Frailty Index (FFI) is a well-established phenotypic tool to assess frailty, its administration is cumbersome. The FRAIL scale, simpler but not widely used in patients with IBD, presents an alternative. We aimed to assess …
The Role of Notch Signaling and Gut Microbiota in Autoinflammatory Diseases: Mechanisms and Future Views
Publication Year: 2025 Source: Biomedicines PMID: 40299348
Notch signaling is an evolutionarily conserved, multifunctional pathway involved in cell fate determination and immune modulation and contributes to the pathogenesis of autoinflammatory diseases. Emerging evidence reveals a bidirectional interaction between Notch and the gut microbiota (GM), whereby GM composition is capable of modulating Notch signaling through the binding of …
Introducing a Novel Personalized Microbiome-Based Treatment for Inflammatory Bowel Disease: Results from NostraBiome's Internal Validation Study
Publication Year: 2025 Source: Biomedicines PMID: 40299351 DOI: 10.3390/biomedicines13040795
Background/Objectives: Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is characterized by chronic gut inflammation driven by microbial dysbiosis and immune dysfunction. Current therapies primarily involve anti-inflammatory and immunomodulatory strategies; however, many patients experience an inadequate response or a gradual loss of efficacy over time. This study evaluates …
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