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The Association Between Severity of Constipation and Oral Frailty Index-8 in the JUSTICE-TOKYO Study: A Cross-Sectional Study
Publication Year: 2025 Source: Biomedicines PMID: 40299439
Background/Objectives: Reports on oral frailty as a risk factor for chronic constipation are scarce. In this study, we examined the relationship between Oral Frailty Index-8 (OFI-8) and constipation severity. Methods: This cross-sectional analysis involved patients aged >/=65 years (outpatients between November 2020 and November 2021). Patient background (age, sex, body …
In Situ Self-Assembled Probe for Antioxidant and Anti-Inflammatory Therapy of Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Appl Bio Mater PMID: 40299753 DOI: 10.1021/acsabm.5c00394
Inflammatory bowel disease (IBD) is a chronic and relapsing disease of the gastrointestinal tract. At present, antioxidant therapy is a promising strategy for IBD treatment. Since low-molecular-weight antioxidants (e.g., 2,2,6,6-tetramethylpiperidin-N-oxyl (TEMPO)) have a short in vivo half-life and inadequate cellular uptake, researchers have focused on loading antioxidants into nanostructures for …
Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling
Publication Year: 2025 Source: PLoS Pathog PMID: 40300021
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS). Intriguingly, the prevalent foodborne parasite Toxoplasma gondii has not been linked to the development of PI-IBS and the impact of this …
Effects of the regenerating gene family on DSS-induced ulcerative colitis in a mouse model
Publication Year: 2025 Source: Biochem Biophys Res Commun PMID: 40300333 DOI: 10.1016/j.bbrc.2025.151894
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by immune dysregulation and defective mucosal healing, predominantly affecting the colonic and rectal mucosa with diffuse inflammation and ulceration. Its pathogenesis involves genetic susceptibility, immune dysfunction, and environmental triggers. The regenerating gene (Reg) family, identified over four decades ago, …
Clca1 deficiency exacerbates colitis susceptibility via impairment of mucus barrier integrity and gut microbiota homeostasis
Publication Year: 2025 Source: Microbiol Res PMID: 40300372
The intestinal mucus barrier has emerged as a promising therapeutic target for inflammatory bowel disease. Understanding its regulatory mechanisms is critical for elucidating ulcerative colitis (UC) pathogenesis, improving diagnostics, guiding treatments, and preventing relapse. Chloride Channel Accessory 1 (Clca1), a constituent of the mucus layer, remains understudied in colitis. Here, …
Natural History of Anal Strictures in Pediatric-Onset Crohn's Disease: Long-term Follow-up of a Population-Based Study
Publication Year: 2025 Source: Dis Colon Rectum PMID: 40300639
BACKGROUND: The risk and clinical course of anal stricture observed in Crohn's disease remains poorly known, particularly in pediatric-onset Crohn's disease. OBJECTIVE: To investigate the long-term clinical course of anal stricture in pediatric-onset Crohn's disease using data from a population-based cohort. DESIGN: A retrospective observational study from a prospective population-based …
Impact of prophages on gut microbiota and disease associations
Publication Year: 2025 Source: Microb Pathog PMID: 40300731
The gut microbiota plays an important role in maintaining host health by affecting various physiological functions. Among the diverse microbial communities in the gut, prophages are integral components of bacterial genomes, contributing significantly to bacterial evolution, ecology and pathogenicity. Prophages are capable of switching to lytic cycles in response to …
Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease
Publication Year: 2025 Source: Intest Res PMID: 40300749 DOI: 10.5217/ir.2024.00185
Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions affecting the gastrointestinal tract that can lead to multiple systemic complications. Among these, osteosarcopenia has emerged as a significant concern, characterized by the concurrent deterioration of bone density and muscle mass, strength, and function. This dual deterioration significantly elevates …
Comparing Outcomes With Subcutaneous Infliximab (CT-P13 SC) by Baseline Immunosuppressant Use: A Post Hoc Analysis of the LIBERTY-CD and LIBERTY-UC Studies
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40300779
BACKGROUND: Superior efficacy of subcutaneous infliximab (CT-P13 SC) over placebo for maintenance therapy in patients with Crohn's disease (CD) and ulcerative colitis (UC) was demonstrated in the randomized LIBERTY-CD and LIBERTY-UC studies. The current post hoc analysis compared outcomes with CT-P13 SC by baseline immunosuppressant use. METHODS: Patients with moderately …
Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn's disease: Association with inflammation and fibrosis
Publication Year: 2025 Source: Dig Liver Dis PMID: 40300947 DOI: 10.1016/j.dld.2025.04.015
BACKGROUND/AIMS: Intestinal strictures in Crohn's disease (CD), driven by fibrosis remain challenging to treat. Current treatments focus on inflammation, but are less effective against fibrosis. Endoplasmic Reticulum Stress-Related Proteins, including Protein disulfide isomerases (PDIs), may contribute to fibrosis; their roles in CD remain unclear. This study investigated the distribution of …
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