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Menopausal hormone therapy is a risk factor for microscopic colitis: findings from a nationwide, matched case-control study
Publication Year: 2025 Source: Gut PMID: 40301113 DOI: 10.1136/gutjnl-2025-335006
No Abstract
Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD
Publication Year: 2025 Source: Gut PMID: 40301114 DOI: 10.1136/gutjnl-2024-333729
BACKGROUND: IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A systematic comparison of commonly used IBD models is essential to identify conserved molecular mechanisms and improve translational relevance. OBJECTIVE: We performed …
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis
Publication Year: 2025 Source: Gut PMID: 40301115 DOI: 10.1136/gutjnl-2024-334346
BACKGROUND: Inflammatory bowel diseases (IBDs) are characterised by dysbiosis and a leaky gut. The NADPH oxidase dual oxidase 2 (DUOX2) is upregulated in patients with IBD, yet its role in driving the disease remains unclear. OBJECTIVE: We interrogated the functional consequences of epithelial DUOX2 activity for the host and microbiome. …
Translational strategies for oral delivery of faecal microbiota transplantation
Publication Year: 2025 Source: Gut PMID: 40301116 DOI: 10.1136/gutjnl-2025-335077
Faecal microbiota transplantation (FMT) has emerged as a transformative therapy for Clostridioides difficile infections and shows promise for various GI and systemic diseases. However, the poor patient acceptability and accessibility of 'conventional' FMT, typically administered via colonoscopies or enemas, hinders its widespread clinical adoption, particularly for chronic conditions. Oral administration …
Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation
Publication Year: 2025 Source: Nat Commun PMID: 40301356
The gut microbiome contributes to chronic inflammatory responses in ulcerative colitis (UC), but molecular mechanisms and disease-relevant effectors remain unclear. Here we analyze the pro-inflammatory properties of colonic fluid obtained during colonoscopy from UC and control patients. In patients with UC, we find that the pelletable effector fraction is composed …
Healthcare transition and inflammatory bowel disease: the challenges experienced by young adults after transfer from paediatric to adult health services
Publication Year: 2025 Source: Psychol Health Med PMID: 40301717 DOI: 10.1080/13548506.2025.2497001
In recent years, there has been a steady increase in research on healthcare transition for patients with Inflammatory Bowel Disease (IBD). However, the focus has been mainly on preparing young people for the transfer to adult health services. Consequently, there is limited information on the post-transfer challenges and perspectives of …
A framework for predictive modeling of microbiome multi-omics data: latent interacting variable-effects (LIVE) modeling
Publication Year: 2025 Source: BMC Bioinformatics PMID: 40301728 DOI: 10.1186/s12859-025-06134-z
BACKGROUND: The number and size of multi-omics datasets with paired measurements of the host and microbiome is rapidly increasing with the advance of sequencing technologies. As it becomes routine to generate these datasets, computational methods to aid in their interpretation become increasingly important. Here, we present a framework for integration …
Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH(2)@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40247297
Ulcerative colitis (UC) is a complex and chronic inflammatory bowel disease whose pathogenesis involves genetic and environmental factors, which poses a challenge for treatment. Here, we have designed an innovative integrated therapeutic strategy using Lactobacillus acidophilus extracellular vesicles (EVs) to encapsulate UiO-66-NH(2) nanoparticles bounded with TNF-alpha siRNA (EVs@UiO-66-NH(2)@siRNA) for UC …
Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn's disease
Publication Year: 2025 Source: J Transl Med PMID: 40247299
BACKGROUND: Intestinal fibrosis is a serious complication of Crohn's disease (CD), often resulting from chronic inflammation. However, the precise mechanisms through which inflammation induces intestinal fibrosis remain inadequately elucidated. METHODS: A comprehensive single-cell atlas of full-thickness CD, provided by Dr. Florian Rieder, was subjected to reanalysis. Our study used a …
Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study
Publication Year: 2025 Source: BMC Med Genomics PMID: 40247302 DOI: 10.1186/s12920-025-02143-2
BACKGROUND: Recent observational studies have revealed an inconclusive correlation between inflammatory bowel disease (IBD) and sepsis, accompanied by an uncertain understanding of the causal relationship between the two. To investigate the causality between IBD and sepsis, we employed a two-sample Mendelian randomization (MR) approach. METHODS: A genome-wide significant threshold (P …
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