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Recent developments in managing luminal microbial ecology in patients with inflammatory bowel disease: from evidence to microbiome-based diagnostic and personalized therapy
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40247656 DOI: 10.1080/17474124.2025.2495087
INTRODUCTION: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic condition characterized by abnormal immune responses and intestinal inflammation. Emerging evidence highlights the vital role of gut microbiota in IBD's onset and progression. Recent advances have shaped diagnostic and therapeutic strategies, increasingly focusing on microbiome-based personalized …
Histology in Inflammatory Bowel Disease: A Redundant Tool or a Valuable Prognostic Marker?
Publication Year: 2025 Source: J Crohns Colitis PMID: 40247688
No Abstract
β-Glucan Extracted from Pichia kudriavzevii DPUL-51-6Y, Kluyveromyces marxianus DPUL-F15, and Saccharomyces cerevisiae DPUL-C6 Shows Ameliorating Effects on DSS-Induced Ulcerative Colitis on BALB/c Mice
Publication Year: 2025 Source: J Agric Food Chem PMID: 40247719
beta-Glucans derived from yeast are recognized as beneficial food additives. This study evaluated crude beta-glucan extracts from Pichia kudriavzevii DPUL-51-6Y, Kluyveromyces marxianus DPUL-F15, and Saccharomyces cerevisiae DPUL-C6 strains for their anticolitis potential. Chemical analysis revealed that beta-glucan was the primary component (71.88-78.47% purity). Notably, the S. cerevisiae extract displayed superior …
Frequency and Characteristics of Gastrointestinal Diseases in Patients With Neurofibromatosis
Publication Year: 2025 Source: JGH Open PMID: 40247846
BACKGROUND AND AIM: Patients with neurofibromatosis (NF) frequently experience gastrointestinal symptoms, but the specific characteristics of these lesions are not well understood. METHODS: To investigate the prevalence and nature of gastrointestinal diseases in this population, we analyzed the gastrointestinal lesions identified through endoscopic examinations in patients with NF. RESULTS: We …
Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn's disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 40248056 DOI: 10.3748/wjg.v31.i13.104671
Eukaryotic cells contain the endoplasmic reticulum (ER), a prevalent and intricate membranous structural system. During the development of inflammatory bowel disease (IBD), the stress on the ER and the start of the unfolded protein response are very important. Some chemicals, including 4mu8C, small molecule agonists of X-box binding protein 1, …
Role of gut microbiota and mesenteric adipose tissue in the pathology of Crohn's disease: Potential therapeutic targets
Publication Year: 2025 Source: World J Gastroenterol PMID: 40248060 DOI: 10.3748/wjg.v31.i13.102291
This editorial comments on the article by Wu et al in the World Journal of Gastroenterology. The article explored the relationship between mesenteric adipose tissue, creeping fat, inflammation, and gut microbiota in Crohn's disease (CD). We discussed three key aspects of the interaction between gut microbiota and inflammatory bowel disease …
Reduced interleukin-2 receptor subunit γ expression in Crohn's disease: A potential mechanism for γδ T cell deficiency
Publication Year: 2025 Source: World J Gastroenterol PMID: 40248067
Crohn's disease (CD) is a chronic inflammatory disorder characterized by dysregulated immune responses and significant disruption of intestinal immunity. A recent case-control study by Andreu-Ballester et al revealed decreased expression of interleukin (IL)-2 receptor subunit gamma (CD132) in CD tissues, a finding that has profound implications for understanding immune dysregulation …
Remission of OCD and ulcerative colitis with a ketogenic diet: Case Report
Publication Year: 2025 Source: Front Psychiatry PMID: 40248603
BACKGROUND: There is little research describing the clinical use of a ketogenic diet in obsessive-compulsive disorder (OCD) or inflammatory bowel disease. We describe the first clinical application of a ketogenic diet in adult OCD with ulcerative colitis (UC) resulting in complete remission of OCD, clinical remission of UC, and improved …
Biglycan deficiency alleviates intestinal fibrosis through BMP-7-mediated Smad1/5/8 signaling
Publication Year: 2025 Source: J Crohns Colitis PMID: 40249230
BACKGROUND: Biglycan (BGN) is a small proteoglycan rich in leucine, which plays a crucial role in the excessive production of extracellular matrix (ECM) and its association with fibrosis across various organs. Nevertheless, the precise contribution of BGN to intestinal fibrosis remains undisclosed. This study aimed to investigate the role and …
Deep Immune Phenotyping Reveals Distinct Immunopathogenesis in Checkpoint Inhibitor-Induced Colitis Compared with Ulcerative Colitis
Publication Year: 2025 Source: Cancer Immunol Res PMID: 40249283
Although initially assumed to be similar, immune checkpoint inhibitor (ICI)-induced autoimmunity can differ from spontaneous autoimmune disease in regard to clinical presentation, pathogenesis, and therapy. Despite limited pathogenetic understanding, ICI-induced colitis (irColitis), a common adverse event during ICI therapy, is treated analogously to its autoimmune counterpart, ulcerative colitis (UC). Thus, …
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