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High long-term retention rates of Secukinumab in psoriatic arthritis and ankylosing spondylitis: a 3-year interim analysis from the observational, prospective SERENA study, in Greek patients
Publication Year: 2025 Source: Rheumatol Int PMID: 40249514
SERENA is a recently completed, non-interventional, multinational, 5-year study evaluating retention, effectiveness, patient-reported outcomes and safety of secukinumab in patients with moderate-to-severe psoriasis, active psoriatic arthritis (PsA), and active ankylosing spondylitis (AS) treated in real-world settings. Three-year interim data from PsA and AS patients treated in Greek centres are presented …
Exochorda racemosa attenuates DSS-induced colitis in C57BL/6 J mice by regulating inflammatory factors, reducing oxidative stress, and modulating intestinal flora
Publication Year: 2025 Source: Phytomedicine PMID: 40250030
BACKGROUND: Exochorda racemosa is a member of the genus Exochorda in the Rosaceae family. Its tender leaves and buds are favored as a unique wild vegetable by people in central China. PURPOSE: This study systematically evaluated the pharmacological safety and anti-inflammatory efficacy of E. racemosa extracts, with concurrent identification and …
Juglone alleviates pelvic pain and prostatic inflammation via inhibiting the activation of NLRP3 inflammasome and alleviating oxidative stress in EAP mice
Publication Year: 2025 Source: Phytomedicine PMID: 40250034
BACKGROUND: Juglone, a naphthoquinone compound that occurs naturally, is present predominantly in the fruits, leaves, and roots of walnut plants. Although its antioxidant and anti-inflammatory effects have been demonstrated in various diseases, its therapeutic potential remains unexplored in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). PURPOSE: Our objective was …
A systematic review on the role of gut microbiome in inflammatory bowel disease: Spotlight on virome and plant metabolites
Publication Year: 2025 Source: Microb Pathog PMID: 40250496 DOI: 10.1016/j.micpath.2025.107608
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, arise from various factors such as dietary, genetic, immunological, and microbiological influences. The gut microbiota plays a crucial role in the development and treatment of IBD, though the exact mechanisms remain uncertain. Current research has yet to definitively establish the …
Spanish Working Group in Crohn's Disease and Ulcerative Colitis (GETECCU) position paper for the management of non-perianal fistulizing Crohn's disease
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40250758
Crohn's disease consists on a complex condition where, despite most patients initially present with an inflammatory behavior, a significant proportion develop complicated lesions such as strictures, fistulas, abscesses, or even perforations. These lesions progressively increase over time and are associated with a higher risk of surgery and hospitalization. Despite significant …
Structural Variations in Ulcerative Colitis-associated Escherichia coli Reduce Fructose Utilization and Aggravate Inflammation Under High-Fructose Diet
Publication Year: 2025 Source: Gastroenterology PMID: 40250773
BACKGROUND AND AIMS: Structural variations (SVs) have significant effects on microbial phenotypes. The underlying mechanism of functional changes caused by gut microbial SVs in the development of ulcerative colitis (UC) need further investigation. METHODS: We performed long-read (Oxford Nanopore Technology-based) and short-read (Illumina-based) metagenomic sequencing on stool samples from 93 …
Elevated fecal calprotectin: Does capsule endoscopy have a role in the diagnostic algorithm?
Publication Year: 2025 Source: Rev Gastroenterol Mex (Engl Ed) PMID: 40251054
INTRODUCTION: The purpose of this study was to examine the utility of small bowel capsule endoscopy (SBCE) in the diagnostic pathway of patients that had elevated fecal calprotectin (FC) and normal colonoscopy. METHODS: Patients with elevated FC and normal colonoscopy that underwent SBCE in the last 4 years were included. …
Pyoderma gangrenosum: a 22-year follow-up of patients in a tertiary reference hospital in Brazil
Publication Year: 2025 Source: An Bras Dermatol PMID: 40251072
BACKGROUND: Pyoderma gangrenosum (PG) is a rare dermatosis often associated with systemic diseases. There are autoinflammatory mechanisms with neutrophilic infiltrate and necrosis. Due to the high morbidity, variable response to therapy and lack of treatment standardization, PG constitutes a highly burdensome condition. OBJECTIVES: To evaluate the epidemiological, clinical and laboratory …
Decoding the genetic and environmental forces in propelling the surge of early-onset colorectal cancer
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 40251115
Early-onset colorectal cancer (EOCRC) shows a different epidemiological trend compared to later-onset colorectal cancer, with its incidence rising in most regions and countries worldwide. However, the reasons behind this trend remain unclear. The etiology of EOCRC is complex and could involve both genetic and environmental factors. Apart from Lynch syndrome …
Optimizing prediction of metastasis among colorectal cancer patients using machine learning technology
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40251500 DOI: 10.1186/s12876-025-03841-y
BACKGROUND AND AIM: Colorectal cancer is among the most prevalent and deadliest cancers. Early prediction of metastasis in patients with colorectal cancer is crucial in preventing it from the advanced stages and enhancing the prognosis among these patients. So far, previous studies have been conducted to predict metastasis in colorectal …
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