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Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease
Publication Year: 2025 Source: Pathophysiology PMID: 40265438 DOI: 10.3390/pathophysiology32020013
BACKGROUND/OBJECTIVES: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum cholesterol levels and inflammation, both of which are dysregulated in inflammatory bowel disease (IBD). Free cholesterol (FC) and the various types of cholesteryl ester (CE) have different functions in the body. However, it is not yet known whether these lipids undergo …
Comment on "The mediating effect of blood biomarkers in the associations between inflammatory bowel disease and incident psychiatric disorders: a prospective cohort study"
Publication Year: 2025 Source: Int J Surg PMID: 40265483
No Abstract
Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007-2023)
Publication Year: 2025 Source: Vaccines (Basel) PMID: 40266085 DOI: 10.3390/vaccines13030230
Introduction: Invasive bacterial diseases (IBDs) such as meningitis and sepsis are significant public health concerns, particularly in pediatric populations. This study analyzes the incidence, outcomes, and bacterial serotype distribution of pediatric IBDs in the Veneto Region over 17 years. Methods: An observational study was conducted using data (2007-2023) from the …
Contraception, Unintended Pregnancy, and Inflammatory Bowel Disease: When (and Why) Failure is Not an Option…
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40266964
No Abstract
Bioaccessible (Poly)phenols of Winery Byproducts Modulate Pathogenic Mediators of Intestinal Bowel Disease: In Vitro Evidence
Publication Year: 2025 Source: J Agric Food Chem PMID: 40267141
Intestinal inflammation entails a multifactorial pathophysiology, frequently treated by using anti-inflammatory drugs with severe side effects. At the same time, bioactive compounds present in plant materials and derived residues could contribute to reducing the use of such medications in terms of dosage and treatment length. Thus, the phytochemicals of winery …
Lab-on-a chip electrochemical sensing platform for simultaneous, ultra-sensitive and on-spot detection of 4-aminosalicylic acid and 5-aminosalicylic acid based on synergistic potential of chitosan functionalized MWCNTs supported on Ni doped Bi(2)S(3)
Publication Year: 2025 Source: Chemosphere PMID: 40267767
Mesalamine or 5-aminosalicylic acid (5-ASA) and its isomer 4-aminosalicylic acid (4-ASA), well known key therapeutic agents used to treat inflammatory bowel diseases (IBDs) can pose toxicity risks upon unregulated consumption. However, their simultaneous real-time detection from physiological fluids like urine remains unexplored. This study presents an innovative electrochemical sensing platform …
Identification and Verification of B4GALNT2 as an Epigenetic Marker in Ulcerative Colitis
Publication Year: 2025 Source: Digestion PMID: 40267892
INTRODUCTION: Ulcerative colitis (UC) represents an inflammatory bowel disease characterized with a multifaceted pathogenesis, which may be attributed to influence by genetic factors. This study aimed to identify and validate novel markers associated with UC, with a specific focus on their regulation through DNA methylation. METHODS: Gene expression and DNA …
OSaMPle workflow for salivary metaproteomics analysis reveals dysbiosis in inflammatory bowel disease patients
Publication Year: 2025 Source: NPJ Biofilms Microbiomes PMID: 40268913 DOI: 10.1038/s41522-025-00692-z
The human oral microbiome has been associated with multiple inflammatory conditions including inflammatory bowel disease (IBD). Identifying functional changes in oral microbiome by metaproteomics helps understanding the factors driving dysbiosis related to intestinal diseases. However, enriching bacterial cells from oral samples (such as saliva and mouth rinse) rich in host …
Spontaneous multiple small bowel perforations due to ischemic enteritis: a case report
Publication Year: 2025 Source: BMC Geriatr PMID: 40269728
INTRODUCTION: Spontaneous multiple small bowel perforation refers to the complete transmural disruption of the intestinal wall and is often associated with conditions such as inflammatory bowel disease, infectious enteritis, drugs or autoimmune diseases, and it affects all age groups. Spontaneous multiple small bowel perforations due to ischemic enteritis is a …
Causal relationship between atherosclerosis and inflammatory bowel disease risk: a two-sample Mendelian randomization study
Publication Year: 2025 Source: Thromb J PMID: 40269871 DOI: 10.1186/s12959-025-00722-y
OBJECTIVE: This study was to evaluate the causal associations of atherosclerosis with the risk of inflammatory bowel disease (IBD), and its subtypes [ulcerative colitis (UC) and Crohn's disease (CD)]: a two-sample Mendelian randomization study. MATERIALS AND METHODS: Single nucleotide polymorphism (SNPs) associated with atherosclerosis including CPAmax, CPSmax, brachial-femoral pulse wave …
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