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Gut microbiota development across the lifespan: Disease links and health-promoting interventions
Publication Year: 2025 Source: J Intern Med PMID: 40270478
The gut microbiota plays a pivotal role in human life and undergoes dynamic changes throughout the human lifespan, from infancy to old age. During our life, the gut microbiota influences health and disease across life stages. This review summarizes the discussions and presentations from the symposium "Gut microbiota development from …
Acute Bowel Perforation Post-Bowel Preparation in a Patient with Connective Tissue Disease
Publication Year: 2025 Source: Eur J Case Rep Intern Med PMID: 40270663
Isosmotic oral agents are commonly used in bowel preparation due to their minimal side effects. However, bowel perforation is a rare and severe complication. Connective tissue disease and medications such as nonsteroidal anti-inflammatory drugs/steroids can weaken the colonic wall, which increases the risk of perforation. We present a case of …
Inorganic dietary nanoparticles in intestinal barrier function of inflammatory bowel disease: allies or adversaries?
Publication Year: 2025 Source: Front Immunol PMID: 40270957 DOI: 10.3389/fimmu.2025.1563504
Inorganic dietary nanoparticles (IDNPs) are frequently utilized as food additives and in packaging, resulting in their exposure becoming a substantial yet often overlooked concern for patients with inflammatory bowel disease (IBD). Considering that impaired intestinal barrier function plays a central role in the pathogenesis of IBD, this review concentrates on …
Combating Methotrexate Resistance in Cancer Treatment: A Review on Navigating Pathways and Enhancing Its Efficacy With Fat-Soluble Vitamins
Publication Year: 2025 Source: Scientifica (Cairo) PMID: 40270992 DOI: 10.1155/sci5/8259470
Methotrexate (MTX), a potent analogue and antagonist of folic acid, is a first-line treatment for rheumatoid arthritis, IBD and cancer. The development of MTX resistance contributes to the reduced efficacy and development of adverse reactions, forcing clinicians to withdraw treatment early. This drawback requires combinational approaches to combat the resistance …
Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential
Publication Year: 2025 Source: Front Pharmacol PMID: 40271055
Ulcerative colitis (UC), a chronic inflammatory bowel disease, is driven by dysregulated immune responses and persistent intestinal inflammation. Pyroptosis, a caspase/gasdermin-mediated inflammatory cell death that exacerbates mucosal damage through excessive cytokine release and epithelial barrier disruption. Although pyroptosis is considered to be a key mechanism in the pathogenesis of UC, …
Jejunal Lipoma-Induced Intussusception Mimicking Crohn's Disease: A Case Report
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40271495
INTRODUCTION: Chronic gastrointestinal bleeding in patients with Crohn's disease presents diagnostic challenges. Adult intussusception is rare and typically caused by a pathological lead point, such as a tumor or inflammatory lesion. Lipomas, though benign, can lead to obstruction and bleeding, requiring differentiation from inflammatory causes for appropriate management. CASE PRESENTATION: …
The impact of COVID-19 on inflammatory bowel disease surgery: a systematic review
Publication Year: 2025 Source: Ann R Coll Surg Engl PMID: 40272168 DOI: 10.1308/rcsann.2025.0016
INTRODUCTION: The COVID-19 pandemic caused a significant disruption to the delivery of surgical services. Guidance prioritising life-saving and cancer surgery was issued. Inflammatory bowel disease (IBD) often requires considered, timely surgery, which may have not been feasible under the conditions imposed by the pandemic. This systematic review aims to quantify …
Systematic review and meta-analysis of cytomegalovirus-associated adverse outcomes and healthcare resource utilization in hospitalized patients with inflammatory bowel disease
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40272527 DOI: 10.1007/s00384-025-04886-x
PURPOSE: Serious complications and unplanned healthcare utilization are reported among inflammatory bowel disease (IBD) hospitalizations with associated cytomegalovirus (CMV). The present systematic review and meta-analysis aimed to examine the in-hospital outcomes of CMV-related hospitalization in IBD patients. METHODS: Electronic databases were systematically searched in PubMed, Web of Science (ISI), Scopus, …
Perception and Understanding of Artificial Intelligence Among Gastroenterology Fellows and Early Career Gastroenterologists: A Nationwide Cross-Sectional Survey Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40272661
INTRODUCTION: Artificial intelligence (AI) is expanding rapidly in healthcare, particularly in gastroenterology (GI). Applications include enhancing colonoscopy accuracy, identifying dysplasia, and predicting clinical outcomes in inflammatory bowel disease. Despite AI's potential, concerns about ethical use and inadequate training persist. AIMS: This study aimed to evaluate the perceptions and understanding of …
Low-background Near-infrared Fluorescent Probe for Real-time Monitoring of β-Glucuronidase Activity in Inflammation and Therapy
Publication Year: 2025 Source: Anal Chem PMID: 40272894
beta-Glucuronidase (GUS) is an acidic hydrolase enzyme overexpressed in various inflammatory diseases, making it a promising biomarker for inflammation. However, current tools for real-time, in situ imaging of GUS activity are hindered by background interference, which reduces their effectiveness in dynamic biological environments. To address this challenge, we developed Ox-GUS, …
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