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Development and psychometric validation of a patient-reported outcome measure scale for Crohn's disease anorectal stricture
Publication Year: 2025 Source: J Crohns Colitis PMID: 40273289
BACKGROUND: Anorectal stricture is a severe and debilitating complication of Crohn's disease (CD). Currently, no specific patient-reported outcome measures (PROMs) exist to assess the severity of anorectal stricture or its impact on the quality of life (QoL) among patients with CD. A new PROM scale has been developed to measure …
Validation of the PROMIS Global Physical and Mental Health Scale for Gastrointestinal Disorders: A Large-Scale Cross-Sectional Survey
Publication Year: 2025 Source: Neurogastroenterol Motil PMID: 40273334
BACKGROUND: While the Patient-Reported Outcomes Measurement Information System (PROMIS) global health scales are frequently used to assess individual quality of life, it has yet to be validated in gastrointestinal cohorts. Based on the Rome Foundation Global Epidemiology Survey, the aim of this study was to conduct the most comprehensive psychometric …
Uterine perforation and bowel incarceration following a second trimester abortion
Publication Year: 2025 Source: Int J Surg Case Rep PMID: 40273575
INTRODUCTION: Uterine perforation is a rare but potentially life-threatening complication of elective abortion, often occurring without immediate symptoms. CASE REPORT: This case report describes a 32-year-old woman who developed small bowel incarceration within the uterine cavity following a second-trimester abortion. She presented five days post-procedure with acute abdominal pain, nausea, …
A novel hemizygous nonsense variant in DOCK11 causes systemic inflammation and immunodeficiency
Publication Year: 2025 Source: Clin Immunol PMID: 40274249
Hemizygous germline loss-of-function variants in DOCK11, the gene encoding the dedicator of cytokinesis 11 (DOCK11) have been recently identified to cause variable immunodeficiency and immune dysregulation. Features of immune dysregulation have been reported in all so far identified male patients with damaging variants in DOCK11, commonly manifesting with autoimmune cytopenias, …
Coix Seed Polysaccharide Mitigates Ulcerative Colitis in Mice through the Modulation of Gut Microbiota and Improvement of Intestinal Metabolism Balance
Publication Year: 2025 Source: J Agric Food Chem PMID: 40274530
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a rising incidence globally, whereas existing treatments exhibit significant limitations. Coix seed polysaccharide (CSP), a component of traditional Chinese medicine known for its immunomodulatory and antioxidant properties, has not been thoroughly investigated for its role in UC. In this study, …
[Are antibiotics immunomodulators? An attempt to use vancomycin in the treatment of primary sclerosing cholangitis]
Publication Year: 2025 Source: Zhonghua Gan Zang Bing Za Zhi PMID: 40274555 DOI: 10.3760/cma.j.cn501113-20240424-00225
Primary sclerosing cholangitis (PSC) is a type of chronic idiopathic liver disease characterized by bile duct inflammation and concentric fibrosis. Currently, no drug therapy can change the natural progression of PSC. The mechanism by which PSC is accompanied by the occurrence of inflammatory bowel disease (IBD) is still unclear. Oral …
[Surgical treatment of ulcerative colitis: a 10-year retrospective analysis at a surgical referral center]
Publication Year: 2025 Source: Zhonghua Wei Chang Wai Ke Za Zhi PMID: 40274587
Objective: To investigate the clinical characteristics, postoperative complications, and risk factors for pouchitis in surgical patients with ulcerative colitis (UC). Methods: This was a retrospective observational study. The clinical data of 336 UC patients who had undergone surgical treatment at the Inflammatory Bowel Disease Center of the Department of General …
'Nobody wants to talk about that stuff': a qualitative investigation of the anticipated public perceptions of individuals with Inflammatory Bowel Disease
Publication Year: 2025 Source: Psychol Health PMID: 40275646 DOI: 10.1080/08870446.2025.2493872
OBJECTIVE: Little research has explored in-depth qualitative opinions on anticipated public views of Inflammatory Bowel Disease (IBD) among those with the condition, and the potential impact of these views on wellbeing. This study explored the perceptions and reactions anticipated by those with IBD from the public (RQ1), and the impact …
Artificial intelligence in inflammatory bowel disease
Publication Year: 2025 Source: Saudi J Gastroenterol PMID: 40275746 DOI: 10.4103/sjg.sjg_46_25
Inflammatory bowel disease (IBD) is a complex condition influenced by various intestinal factors. Advances in next-generation sequencing, high-throughput omics, and molecular network technologies have significantly accelerated research in this field. The emergence of artificial intelligence (AI) has further enhanced the efficient utilization and interpretation of datasets, enabling the discovery of …
Endoscopic submucosal dissection for visible dysplasia in inflammatory bowel disease: a nationwide multicenter cohort from the GETAID and the SFED
Publication Year: 2025 Source: J Crohns Colitis PMID: 40275777 DOI: 10.1093/ecco-jcc/jjaf057
BACKGROUND AND AIMS: New techniques for endoscopic resection, including endoscopic submucosal dissection (ESD), have been developed to allow for en-bloc resection with very low recurrence rates and organ sparing in patients without inflammatory bowel disease (IBD). Data on ESD for the management of colorectal dysplasia in IBD patients are scarce. …
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