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Efficacy and safety of etrasimod in Japanese patients with ulcerative colitis: results from a phase 2 dose-ranging study
Publication Year: 2025 Source: Intest Res PMID: 40275818
BACKGROUND/AIMS: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). However, its efficacy, safety, and the appropriate dosage have not been extensively investigated in the Japanese population. METHODS: This phase 2, multicenter, randomized, double-blind, placebo-controlled dose-ranging, 12-week trial …
Pilot Study of Fecal Mitochondrial DNA in Inflammatory Bowel Disease Patients Demonstrates a High Sensitivity Assay With Likely Capacity to Differentiate Between Disease and Histologic Remission
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40275932
No Abstract
Asymptomatic Wilson's Disease Diagnosed during the Course of Ulcerative Colitis: A Case Report and Review
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40276013
INTRODUCTION: While previous reports have suggested an association between Wilson's disease (WD) and ulcerative colitis (UC), we present the first case of asymptomatic WD diagnosed during the treatment course of UC. CASE PRESENTATION: A 14-year-old male receiving treatment for UC developed elevated liver enzymes without any related symptoms. After ruling …
The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats
Publication Year: 2025 Source: Open Vet J PMID: 40276184 DOI: 10.5455/OVJ.2025.v15.i3.26
BACKGROUND: Piroxicam, a nonsteroidal antiinflammatory drug, is commonly used to induce inflammation in experimental models of inflammatory bowel disease (IBD). Piroxicam can modulate the immune system and disrupt the mucosal barrier, leading to increased production of reactive oxygen species. AIM: This study aimed to evaluate the effects of single-clove garlic …
Development and validation of identification algorithms for five autoimmune diseases using electronic health records: a retrospective cohort study in China
Publication Year: 2025 Source: Front Immunol PMID: 40276516 DOI: 10.3389/fimmu.2025.1541203
OBJECTIVE: This study aims to assess the identification algorithms for five autoimmune diseases-Hashimoto's thyroiditis, inflammatory bowel disease (IBD), primary immune thrombocytopenia (ITP), rheumatoid arthritis (RA), and type 1 diabetes (T1D)-using the Yinzhou Regional Health Information Platform (YRHIP) in China. METHODS: Diagnostic data was extracted from YRHIP's population registry (2010-2021), combining …
A Study of the Spatial Correlogram Patterns of Chinese Surnames
Publication Year: 2025 Source: Am J Hum Biol PMID: 40276959 DOI: 10.1002/ajhb.70050
OBJECTIVES: This study investigates the historical diffusion and migration patterns of Chinese surnames by analyzing their spatial correlograms. The primary objectives are to identify typical correlogram categories, characterize each category, and explore the factors influencing the historical diffusion and migration processes that have shaped the spatial distributions of Chinese surnames. …
Acyloxyacyl Hydrolase Prevents Colitis and Colitis-Associated Colorectal Cancer by Inactivating Stimulatory LPS in the Intestine
Publication Year: 2025 Source: FASEB J PMID: 40277184
Ulcerative colitis (UC) is believed to be triggered by a dysregulated inflammatory response to the intestinal microbiota. Acyloxyacyl hydrolase (AOAH) is a unique host lipase that inactivates Gram-negative bacterial lipopolysaccharides (LPS). After finding that AOAH produced in the intestine decreases stimulatory LPS levels in colon contents, we used the dextran …
Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40277443 DOI: 10.1002/advs.202503307
Millions of people worldwide have inflammatory bowel disease (IBD). Self-driven micro/nanorobots (MNRs) are efficient in the treatment of IBD. However, their lack of controllability regarding direction of motion in the organism and their inability to achieve continuous navigation limits their further application. In this study, polydopamine is wrapped around the …
Inflammation-Associated Carcinogenesis in Inflammatory Bowel Disease: Clinical Features and Molecular Mechanisms
Publication Year: 2025 Source: Cells PMID: 40277893 DOI: 10.3390/cells14080567
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition marked by persistent intestinal inflammation of unknown etiology. Disease onset involves genetic predisposition and environmental factors that disrupt the intestinal immune homeostasis. The intestinal microbiome and immune response play pivotal roles in disease progression. …
The Gut Mycobiome for Precision Medicine
Publication Year: 2025 Source: J Fungi (Basel) PMID: 40278100
The human gastrointestinal tract harbors a vast array of microorganisms, which play essential roles in maintaining metabolic balance and immune function. While bacteria dominate the gut microbiome, fungi represent a much smaller, often overlooked fraction. Despite their relatively low abundance, fungi may significantly influence both health and disease. Advances in …
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