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Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials
Publication Year: 2025 Source: Front Nutr PMID: 40196017 DOI: 10.3389/fnut.2025.1494351
INTRODUCTION: Inflammatory Bowel Disease (IBD), encompassing Crohn disease (CD) and ulcerative colitis (UC), presents complex challenges in management due to dysregulated immune responses and genetic predispositions. This study explored the potential of curcumin as an adjunctive therapy in IBD, assessing its efficacy and safety through a systematic review of clinical …
Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases
Publication Year: 2025 Source: Front Nutr PMID: 40196019
Chronic liver disease is defined by persistent harm to the liver that might result in decreased liver function. The two prevalent chronic liver diseases are alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD). There is ample evidence that the pathogenesis of these two chronic liver diseases is …
Genotype-phenotype correlation in a cohort of pediatric patients with autoinflammatory diseases carrying NOD2 variants
Publication Year: 2025 Source: Front Immunol PMID: 40196132
BACKGROUND: Autoinflammatory diseases (AIDs) are a group of disease characterized by excessive activation of the innate immune system with episodes of spontaneous inflammation that can affect different organs. Many monogenic or acquired autoinflammatory diseases are described in literature. More recently the concept of disease with polygenic or complex inheritance has …
Gender equality in caregiver attendance for children with chronic diseases: a Swedish longitudinal observational study
Publication Year: 2025 Source: BMJ Public Health PMID: 40196439
OBJECTIVES: In countries at the forefront of gender equality policy, mothers still play a more pronounced role than fathers in the provision of parental care for their children. This study aimed to explore gender equality in attendance at doctor's appointments among caregivers of children with chronic diseases before and after …
Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure
Publication Year: 2025 Source: bioRxiv PMID: 40196693 DOI: 10.1101/2025.03.25.645177
BACKGROUND: Colorectal cancer (CRC) results from the accumulation of mutations and epigenetic changes in gut epithelial cells likely due to gut microbiota dysbiosis. However, limited research has been done to explore the link between host tumour dysbiosis and disease outcome. METHODS: The mechanisms influencing outcomes of 97 colorectal cancer (CRC) …
Editorial: Smart endorobots for endoluminal procedures: design, ethics and future trends
Publication Year: 2025 Source: Front Robot AI PMID: 40196842 DOI: 10.3389/frobt.2025.1581829
No Abstract
Improving gut virome comparisons using predicted phage host information
Publication Year: 2025 Source: mSystems PMID: 40197051
The human gut virome is predominantly made up of bacteriophages (phages), viruses that infect bacteria. Metagenomic studies have revealed that phages in the gut are highly individual specific and dynamic. These features make it challenging to perform meaningful cross-study comparisons. While several taxonomy frameworks exist to group phages and improve …
Health Outcomes, Discrimination, and Stigma Among Sexual and Gender Minority People With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40197744 DOI: 10.1093/ibd/izaf054
BACKGROUND: Sexual and gender minority (SGM) individuals often experience more discrimination and worse health than non-SGM people. Less is known about SGM individuals with inflammatory bowel disease (IBD). We studied IBD outcomes, discrimination, illness-related stigma, and SGM status in a cross-sectional survey. METHODS: In total, 1586 IBD Partners e-cohort participants …
Letter: Predictors of Complicated Disease Course in Children and Adults With Ulcerative Colitis-Authors' Reply
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40197995
No Abstract
Efficacy of Mirikizumab in Patients with Prior Ustekinumab Exposure: A Case Series
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40198002
No Abstract
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