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Incidence of Osteoporosis and Osteopenia in Newly Diagnosed Inflammatory Bowel Disease: A Population-Based Cohort Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40198007 DOI: 10.1093/ibd/izaf063
BACKGROUND: Individuals with Crohn's disease (CD) and ulcerative colitis (UC) are at risk of developing osteoporosis. In Denmark, osteoporosis has been observed in 12.0% of postmenopausal women and 2.6% in men aged >/= 50 years in the general population. We aimed to conduct a population-based analysis determining bone mineral density …
Specialized and standard nutritional formulas for the dietary management of pediatric patients with Crohn's disease: a systematic literature review
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40198155 DOI: 10.1080/17474124.2025.2488887
INTRODUCTION: This systematic literature review (SLR) aims to compare the clinical, humanistic, and economic outcomes associated with specialized and standard nutritional formulas for the treatment of mild-to-moderate pediatric Crohn's disease. METHODS: Search strategies were applied across MEDLINE, Cochrane and Web of Science (January 2000-October 2023) and recent congress proceedings (January …
Stoma care: a review of current practice
Publication Year: 2025 Source: Br J Community Nurs PMID: 40198339
Stoma care is a critical aspect of nursing that requires specialised knowledge and skills to ensure optimal health outcomes for patients with surgically created openings. Effective stoma care ensures the patient's physical wellbeing and contributes significantly to psychological adjustment to a life with a stoma. This article discusses the key …
Targeting EZH2 in autoimmune diseases: unraveling epigenetic regulation and therapeutic potential
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40198399 DOI: 10.1007/s00210-025-04127-6
Approximately 8-10% of the global population is affected by autoimmune diseases (ADs), which encompass a wide array of idiopathic conditions resulting from dysregulated immune responses. The enzymatic component of the polycomb-repressive complex 2 (PRC2), enhancer of zeste homolog 2 (EZH2, also referred to as KMT6), functions as a methyltransferase possessing …
Higher Inpatient Racial and Ethnic Diversity Is Associated with Better Outcomes in Hispanic and Native American Patients for Gastrointestinal Diseases
Publication Year: 2025 Source: Dig Dis Sci PMID: 40198527
BACKGROUND: Evidence suggests that outcomes are poorer among patients from historically marginalized racial and ethnic backgrounds. The impact of patient racial and ethnic diversity on gastrointestinal outcomes is understudied. AIMS: To investigate the impact of patient racial/ethnic diversity on gastrointestinal disease (GI) outcomes. METHODS: Using the 2019 National Inpatient Sample …
Distinct Effects between Polystyrene Micro- and Nanoplastics: Exacerbation of Adverse Outcomes in Inflammatory Bowel Disease-like Zebrafish and Mice
Publication Year: 2025 Source: ACS Nano PMID: 40198662 DOI: 10.1021/acsnano.5c02307
Numerous studies have demonstrated that micro- and nanoplastics can induce adverse effects in both zebrafish and mice, primarily targeting the intestine in oral exposure scenarios. Organisms under disease conditions are suggested to exhibit increased susceptibility to environmental pollutants, with inflammatory bowel disease (IBD) serving as a relevant model for understanding …
Oral and oropharyngeal colonization by Enterobacteriaceae: A narrative review on its epidemiology and clinical impact
Publication Year: 2025 Source: Medwave PMID: 40198888
The family encompasses a large group of Gram-negative bacteria of the order Enterobacterales, which are habitual residents of the intestinal and urinary tracts, behaving only as allochthons in the oral cavity. There is no consensus regarding the prevalence, determinants and consequences of high aero-digestive colonization by this family of bacteria. …
Correlation of serum vitamin D levels with serum interleukin-23 levels in patients of ulcerative colitis
Publication Year: 2025 Source: Hum Immunol PMID: 40199019
Ulcerative Colitis (UC) is a chronic inflammatory condition resulting from an abnormal immune response to gut microbiota, leading to cytokine dysregulation, including elevated interleukin-23 (IL-23) levels. Emerging evidence suggests that vitamin D (VD) plays a crucial role in immune modulation. However, its correlation with IL-23 in UC is not well …
Clinical course and prognostic disparities of pyoderma gangrenosum based on underlying disease: A long-term comparative study in 124 patients
Publication Year: 2025 Source: Ann Dermatol Venereol PMID: 40199040 DOI: 10.1016/j.annder.2025.103364
BACKGROUND AND OBJECTIVES: Pyoderma gangrenosum (PG) is associated with inflammatory bowel disease (IBD), autoimmune and connective tissue diseases, and hematologic malignancies. The impact of these underlying diseases on the clinical course and outcomes of PG remains poorly understood. This study investigates the influence of systemic disease associations on the progression, …
Glycine tabacina extract alleviates inflammatory bowel disease via NF-κB, JNK and Nrf2 signaling pathways
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40199409 DOI: 10.1016/j.jep.2025.119744
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the colon, often triggered by unhealthy diets, infections, and dysregulated immune responses. Current treatments for IBD are limited by relapse, drug resistance, side effects, and high costs. Glycine tabacina (Labill.) Benth, a legume native to southeastern China, has traditionally …
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