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Crohn's disease but not ulcerative colitis elevated risk of end-stage renal disease and mortality: A Taiwan retrospective cohort study
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40193679 DOI: 10.1097/MD.0000000000042026
Inflammatory bowel disease (IBD) is an autoinflammatory disease which may affect extraintestinal organs, including kidney. However, rare research showed that patients with IBD have higher risk of end-stage renal disease (ESRD). Furthermore, lack of studies compared the potential risk of ESRD and mortality among patients with ulcerative colitis (UC) and …
Long-term safety of bimekizumab in adult patients with axial spondyloarthritis or psoriatic arthritis: pooled results from integrated phase IIb/III clinical studies
Publication Year: 2025 Source: RMD Open PMID: 40194794
OBJECTIVE: To assess the long-term safety profile of bimekizumab (BKZ) in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS: Safety data pooled from six integrated phase IIb/III studies in axSpA and PsA are reported (to the July 2022 data-cut for phase III) for patients who received >/=1 dose …
3'-Sialyllactose and B. infantis synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis
Publication Year: 2025 Source: Gut Microbes PMID: 40195063
Ulcerative colitis (UC) poses significant threats to human health and quality of life worldwide, as it is a chronic inflammatory bowel disease. 3'-sialyllactose (3'-SL) is a key functional component of milk oligosaccharides. This study systematically evaluates the prebiotic effects of 3'-SL and its therapeutic potential in combination with Bifidobacterium infantis …
Cholangioscope-assisted ERAT for the diagnoses and treatment of ulcerative colitis with appendiceal orifice inflammation: a case report and a literature review
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40195154
PURPOSE: Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease primarily affecting the colorectal mucosa. The disease is characterized by a relapsing-remitting course and is currently incurable. Its pathogenesis is multifactorial, involving genetic predisposition, environmental triggers, immune dysregulation, and alterations in gut microbiota. The appendix plays a role in …
Ulcerative colitis increases the risk of atrioventricular block: evidence from a Mendelian randomized analysis
Publication Year: 2025 Source: Sci Rep PMID: 40195464 DOI: 10.1038/s41598-025-96111-6
Although inflammatory bowel disease (IBD) has been linked to cardiovascular disease in a growing body of literature, the relationship between IBD and arrhythmia remains unclear. To investigate the causal relationship between inflammatory bowel disease and arrhythmia, we conducted this Mendelian randomization (MR) analysis. We identified single nucleotide polymorphisms (SNP) associated …
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC
Publication Year: 2025 Source: Acta Pharmacol Sin PMID: 40195510
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The etiology of UC is multifaceted, and the underlying pathogenesis remains incompletely understood. Pyroptosis, programmed cell death mediated by the gasdermins, is a pivotal driver of UC pathology due to its dual role in epithelial barrier disruption and inflammatory amplification. We …
The impact of early-life and prolonged antibiotics exposure on 78 common diseases: Evidence from epidemiology
Publication Year: 2025 Source: Br J Clin Pharmacol PMID: 40195536
No Abstract
Hormonal therapy for impaired growth due to pediatric-onset inflammatory bowel disease: a systematic review and meta-analysis with trial sequential analysis
Publication Year: 2025 Source: J Pediatr Endocrinol Metab PMID: 40195751 DOI: 10.1515/jpem-2024-0609
INTRODUCTION: Inflammatory bowel diseases (IBDs) have an increasing incidence in the pediatric population. The dysabsorptive effects of this condition often lead to a decrease in linear growth. However, the effectiveness and safety of growth hormone (GH) therapy in this population is still a topic of debate, with studies showing conflicting …
It's time to measure what matters in inflammatory bowel disease
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40195766 DOI: 10.17235/reed.2025.11214/2025
Core Outcome Sets (COS) provide standardized outcomes for randomized controlled trials (RCTs), enhancing consistency and comparability in research. In inflammatory bowel disease (IBD), the CORE-IBD Collaborators developed the first COS for RCTs, while the European Crohn's and Colitis Organisation (ECCO) later introduced a COS for real-world data, addressing key domains …
Uncovering shared genetic features between inflammatory bowel disease and systemic lupus erythematosus
Publication Year: 2025 Source: Res Sq PMID: 40196008 DOI: 10.21203/rs.3.rs-5804830/v1
BACKGROUND: Inflammatory bowel disease (IBD) is an autoimmune disease (AD) characterized by chronic, relapsing intestinal inflammation. Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement and overactivation of both innate and adaptive immunity. The extra intestinal manifestations (EIMs) that commonly occur in IBD include many of the …
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