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Editorial: Gut microbiota and gastrointestinal disorders, volume II
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40166060
No Abstract
Composition of plant-based diets and the incidence and prognosis of inflammatory bowel disease: a multinational retrospective cohort study
Publication Year: 2025 Source: Lancet Reg Health Eur PMID: 40166364 DOI: 10.1016/j.lanepe.2025.101264
BACKGROUND: Many currently proposed diets for inflammatory bowel disease (IBD) focus on increasing plant-based foods, although a vegetarian diet can still contain products such as emulsifiers and refined grains that are believed to negatively impact IBD incidence and progression. To better inform dietary management in IBD, we investigated the association …
Unmet needs in adult patients with ulcerative colitis in Spain: a real-world Adelphi Disease Specific Programme study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40166589 DOI: 10.1177/17562848251325190
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by chronic inflammation of the colonic mucosal lining. OBJECTIVES: This study aimed to examine unmet needs among patients with UC in Spain. DESIGN: Data were analyzed from the Adelphi Real World IBD Disease Specific Programme, a cross-sectional survey of …
Association of Race and Ethnicity With Healthcare Utilization for Inflammatory Bowel Disease in the United States: A Retrospective Cohort Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40167040 DOI: 10.14309/ajg.0000000000003438
INTRODUCTION: Advances in medical and surgical therapy have improved the outlook for those affected with Crohn's disease and ulcerative colitis; however, it is unclear whether Americans from marginalized racial and ethnic backgrounds have adequate and equitable access to care for inflammatory bowel disease (IBD). We evaluated the association between race …
A Swedish cost-utility analysis of ferric derisomaltose versus ferric carboxymaltose in the treatment of iron deficiency anemia in patients with inflammatory bowel disease
Publication Year: 2025 Source: J Med Econ PMID: 40167340 DOI: 10.1080/13696998.2025.2487359
OBJECTIVES: Iron deficiency anemia (IDA) is a common extraintestinal manifestation of inflammatory bowel disease (IBD), driven by impaired iron absorption, inflammation of intestinal mucosa and blood loss due to intestinal bleeding. Exogenous iron is indicated to correct iron deficiency, with intravenous iron preferred in patients with malabsorption or intolerance of …
Perceptions of patients with inflammatory bowel diseases on switching from reference product adalimumab to biosimilar adalimumab-atto
Publication Year: 2025 Source: Expert Opin Biol Ther PMID: 40167456 DOI: 10.1080/14712598.2025.2488222
BACKGROUND: There may be patient concerns with switching to a biosimilar product. The purpose of this study was to describe the perspectives of patients with inflammatory bowel disease (IBD) after switching from reference product (RP) adalimumab to adalimumab-atto. RESEARCH DESIGN AND METHODS: This was a telephonic survey of US patients …
Microbiota-dependent modulation of intestinal anti-inflammatory CD4(+) T cell responses
Publication Year: 2025 Source: Semin Immunopathol PMID: 40167791 DOI: 10.1007/s00281-025-01049-6
Barrier organs such as the gastrointestinal tract, lungs, and skin are colonized by diverse microbial strains, including bacteria, viruses, and fungi. These microorganisms, collectively known as the commensal microbiota, play critical roles in maintaining health by defending against pathogens, metabolizing nutrients, and providing essential metabolites. In the gut, commensal-derived antigens …
Fidaxomicin for Clostridioides difficile infection in patients with inflammatory bowel disease: a multicenter retrospective cohort study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40168072 DOI: 10.1093/ecco-jcc/jjaf056
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) patients with Clostridioides difficile infection (CDI) are at increased risk of adverse outcomes. Data on fidaxomicin use in IBD remain scarce. We assessed the effectiveness and safety of fidaxomicin for CDI and its impact on IBD outcomes in a large international cohort. METHODS: …
Patient-donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 40168084
BACKGROUND AND AIMS: Clinical applications of fecal microbiota transplantation (FMT) for treating ulcerative colitis (UC) have shown promising results. However, whether the beneficial effects of FMT are due to the transfer and colonization of donor-derived species in patients remains unclear. Here, we investigated the factors affecting the efficacy of the …
Corticosteroid-sparing effects of risankizumab efficacy and safety in patients with moderately to severely active ulcerative colitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 40168091
BACKGROUND AND AIMS: This post hoc analysis evaluated the corticosteroid-sparing effects of risankizumab (RZB) therapy in patients with moderate-to-severe ulcerative colitis in the phase 3 induction and maintenance studies, INSPIRE and COMMAND. METHODS: Patients were randomized (2:1) to 12 weeks of intravenous RZB or placebo (PBO) induction therapy; responders to …
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