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The mediating role of psychological inflexibility on internalized stigma and patient outcomes in a sample of adults with inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 40168103 DOI: 10.1093/ecco-jcc/jjaf055
BACKGROUND: This study examined the relationship between psychological inflexibility, internalized stigma, and patient outcomes in adults with inflammatory bowel disease (IBD). It aimed to explore if psychological inflexibility mediated the relationship between internalized stigma and patient outcomes. METHODS: Three hundred and eighty-two participants with IBD took part in a cross-sectional …
The Inflammatory Bowel Disease Knowledge Inventory Device 2 (IBD-KID2) is an effective tool for measuring disease-specific knowledge in Chinese patients
Publication Year: 2025 Source: PLoS One PMID: 40168339 DOI: 10.1371/journal.pone.0321036
BACKGROUND: The Inflammatory Bowel Disease Knowledge Inventory Device 2 (IBD-KID2) is a specialized tool designed to evaluate disease-specific knowledge in patients with inflammatory bowel disease. The aim of this study was to develop a Chinese version of IBD-KID2 and to test the reliability and validity of this tool in Chinese …
Baicalin n-butyl ester alleviates inflammatory bowel disease and inhibits pyroptosis through the ROS/ERK/P-ERK/NLRP3 pathway in vivo and in vitro
Publication Year: 2025 Source: Biomed Pharmacother PMID: 40168722
BACKGROUND: Baicalin is a flavonoid extracted from dried roots of the plant Scutellariabaicalensis. Baicalin n-butyl ester (BNE) is a flavonoid obtained by esterification of baicalin and has anti-inflammatory and antioxidant effects. PURPOSE: The therapeutic efficacy and potential mechanism of BNE in inflammatory bowel disease remain unclear. This study investigated the …
Polydopamine-mediated biointerfacial nanozyme as probiotic protective coating for IBD therapy
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40169054 DOI: 10.1016/j.ijbiomac.2025.142699
Probiotics offer a promising strategy to address the dysfunction of the intestinal mucosal barrier and dysregulation of the gut microbiota in inflammatory bowel disease (IBD). However, the low viability and poor adhesion of probiotics in complex gastrointestinal environments pose significant challenges. To tackle these issues, we designed a specialized protective …
Possible Drug-Drug Interactions Between Mesalamine and Tricyclic Antidepressants Through CYP2D6 Metabolism - In silico and In vitro Analyses
Publication Year: 2025 Source: Drug Res (Stuttg) PMID: 40169140 DOI: 10.1055/a-2551-2418
Mesalamine (mesalazine, 5-aminosalicylic acid, 5-ASA) is an essential anti-inflammatory agent both used for therapy and as a remission control in patients with inflammatory bowel diseases (IBD) such as ulcerative colitis (UC). Tricyclic antidepressants (TCAs) are used to alleviate remaining symptoms in patients already receiving IBD therapy or with quiescent inflammation. …
Altered functional connectivity within and between resting-state networks in ulcerative colitis
Publication Year: 2025 Source: Brain Imaging Behav PMID: 40169477
Patients with ulcerative colitis (UC) often exhibit affective disorders, such as depression and anxiety. The underlying neurological mechanisms of these symptoms, however, remain poorly understood. This study aimed to explore alterations in functional connectivity (FC) both within and between resting-state networks (RSNs) in individuals with ulcerative colitis. Twelve meaningful RSNs …
Multifaceted challenges of deep venous thrombosis in the setting tetraplegia and ulcerative colitis: case report
Publication Year: 2025 Source: Spinal Cord Ser Cases PMID: 40169539
INTRODUCTION: Traumatic spinal cord injury (SCI) tetraplegics are at an increased risk of deep venous thrombosis (DVT) due to immobility and altered hemostasis. Inflammatory bowel diseases such as ulcerative colitis (UC) face an elevated risk of thrombotic events due to chronic inflammation, in addition to the risk of diarrhea and …
Prediction of deep remission through serum TNF-α level at 1 year of treatment in pediatric Crohn's disease
Publication Year: 2025 Source: Sci Rep PMID: 40169633
A pilot study investigated the cytokine profile (IL-6, TNF-alpha, IL-17 A, and IL-10) at diagnosis, affecting infliximab (IFX) trough levels (TLs) in pediatric patients with Crohn's disease (CD). In this follow-up study, we evaluated the changes in cytokine level changes after Crohn's disease treatment. Cytokines were re-measured after 1 year …
Oral administration of Momordica charantia-derived extracellular vesicles alleviates ulcerative colitis through comprehensive renovation of the intestinal microenvironment
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40170075 DOI: 10.1186/s12951-025-03346-6
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD), accompanied by intense inflammation, oxidative stress, and intestinal microbiota dysbiosis. Current treatments using chemotherapeutic drugs or immunosuppressants have limited effectiveness and side effects. Therefore, the development of safe, effective, and multi-targeting therapies for IBD is of great importance. Momordica charantia …
Chiral Zinc Sulfide Nanoparticles Scavenging Reactive Oxygen Species for Remodeling Intestinal Homeostasis
Publication Year: 2025 Source: Angew Chem Int Ed Engl PMID: 40170506 DOI: 10.1002/anie.202503654
Elevated levels of reactive oxygen species (ROS) and gut microbiota dysbiosis are crucial factors that exacerbate inflammatory bowel disease (IBD). To address this, we successfully synthesized zinc sulfide nanoparticles (ZnS NPs) with a particle size of approximately 500 nm and a maximum g-factor of 0.07, utilizing l-/d-cysteine as chiral ligands. …
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