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Managing pregnancy with long-term parenteral nutrition: A case report and review of the literature
Publication Year: 2025 Source: JPEN J Parenter Enteral Nutr PMID: 40170624
Parenteral nutrition (PN) is essential for patients with chronic intestinal failure but poses significant challenges during pregnancy because of increased nutrition needs and associated risks such as central line-associated bloodstream infections. We report a case of a 29-year-old primigravid woman with Crohn's disease who required chronic PN. Despite these complexities, …
A Case Report: Cryptogenic Multifocal Ulcerative Stenosing Enteritis - A Diagnostic Challenge Mimicking Crohn's Disease
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40170795 DOI: 10.1159/000544941
INTRODUCTION: Cryptogenic multifocal ulcerative stenosing enteritis (CMUSE) is a rare and underrecognized small bowel disorder that often mimics Crohn's disease, leading to delays in diagnosis and misdirected treatment. Given its relapsing nature and resistance to conventional inflammatory bowel disease (IBD) therapies, CMUSE presents significant diagnostic and therapeutic challenges. CASE PRESENTATION: …
Relationship of visfatin with obesity and osteoporosis in patients with inflammatory bowel disease: a narrative review
Publication Year: 2025 Source: Front Immunol PMID: 40170859 DOI: 10.3389/fimmu.2025.1533955
BACKGROUND: Inflammatory bowel disease (IBD) is an increasingly prevalent condition in developed countries. Alongside the growing number of patients, there is a rising incidence of disease-related complications, including osteoporosis. While well-established risk factors for low bone mineral density in IBD-such as low body mass or steroid therapy-are widely recognized, other …
Transcranial ultrasound stimulation ameliorates dextran sulphate sodium-induced colitis and behavioural disorders by suppressing the inflammatory response in the brain
Publication Year: 2025 Source: Brain Commun PMID: 40170911 DOI: 10.1093/braincomms/fcaf119
Inflammatory bowel disease (IBD) is associated with neuroinflammation, which may contribute to an increased risk of neurodegenerative disorders. This research investigated the potential of transcranial low-intensity pulsed ultrasound (LIPUS) to mitigate colonic inflammation induced by dextran sulphate sodium (DSS), focusing on its effects via the brain-gut axis. Colitis and neuroinflammation …
Endovascular treatment of patients with aortic and iliac aneurysms and congenital pelvic kidney: a systematic review
Publication Year: 2025 Source: Int Angiol PMID: 40172320 DOI: 10.23736/S0392-9590.24.05350-1
INTRODUCTION: Congenital pelvic kidney is a rare condition that complicates the treatment of abdominal aortic aneurysms due to its variable arterial anatomy. Traditionally, most patients were treated with open or hybrid surgery. However, recent advancements in endovascular devices have allowed to manage complex aortic anatomies. Given the limited data, we …
KunMingShanHaiTang formula reprograms macrophage metabolism and promotes M2 polarization via the HIF-1α pathway to alleviate ulcerative colitis symptoms in a rat model
Publication Year: 2025 Source: J Bioenerg Biomembr PMID: 40172736
The KunMingShanHaiTang Formula (KMSHTF), adjusted by Professor Zhong Chuanhua for the treatment of ulcerative colitis (UC), is the work of a renowned veteran practitioner of Chinese medicine. However, its specific mechanism remains unknown. Consequently, it is intriguing to investigate the molecular mechanism by which KMSHTF treats UC. To elucidate the …
Acute Severe Ulcerative Colitis in the Modern Era Spotlight on Opioids, Small Molecule Therapy, and Interdisciplinary Communication
Publication Year: 2025 Source: Dig Dis Sci PMID: 40172747
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Head-to-Head Comparison of 68 Ga-FAPI-04 and 18 F-FDG PET/CT for the Assessment of Crohn's Disease : A Prospective Pilot Study
Publication Year: 2025 Source: Clin Nucl Med PMID: 40173312
BACKGROUND: Crohn disease is a chronic granulomatous inflammatory disease of gastrointestinal tract. Previous studies showed Crohn disease strictures overexpress fibroblast activation protein and had active 68 Ga-FAPI-04 uptake. Our study was to compare the diagnostic performance of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in Crohn disease. PATIENTS AND METHODS: This …
Enzyme-Mimic Activities of RuCo Bimetallic Nanosheets for Inflammatory Bowel Disease Treatment
Publication Year: 2025 Source: J Am Chem Soc PMID: 40173890 DOI: 10.1021/jacs.5c00100
The presence of abnormal levels of reactive oxygen species (ROS) is a recognized pathological feature of inflammatory bowel disease (IBD). Therefore, the development of orally administered antioxidants with high antioxidative capacity and gastric acid tolerance for the treatment of IBD is of great significance. Here, we present the design and …
IsoalloLCA-intervened regulatory T cell exosomes alleviate inflammatory bowel disease by inhibiting NF-κB-associated inflammation in intestinal epithelial cells
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40174336 DOI: 10.1016/j.intimp.2025.114501
Regulatory T cells (Tregs) are the principal immune cells that exert anti-inflammatory effects within the organism. Their exosomes exhibit therapeutic efficacy across a broad spectrum of diseases owing to their high stability, low immunogenicity, and substantial penetration capacity. Recent research have indicated that isoallolithocholic acid (isoalloLCA), a metabolite associated with …
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