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Human antigen R -mediated autophagy-related gene 3 methylation enhances autophagy-driven ferroptosis in Crohn's disease colitis
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40174340
BACKGROUND AND AIMS: Crohn's disease (CD) is a chronic inflammatory disorder that can affect any part of the gastrointestinal tract, with the exact etiology remaining unclear. Recent studies have implicated the role of human antigen R (HuR) in the pathogenesis of various inflammatory diseases, including CD. However, the role of …
Embracing the unknown: Proteomic insights into the human microbiome
Publication Year: 2025 Source: Cell Metab PMID: 40174574
Protein-level investigations into the human microbiome provide insights into active microbial functions. Recently, Valdes-Mas et al.(1) introduced a metagenome-informed metaproteomics approach to functionally explore species-level microbiome-host interactions and quantify the dietary exposome. Its potential has been implemented in mice and humans to uncover proteomic signatures of health and inflammatory bowel …
Pectin-loaded ferulic acid nanoparticles: A potential therapeutic strategy for ulcerative colitis via modulation of the cGAS-STING pathway
Publication Year: 2025 Source: Toxicol Appl Pharmacol PMID: 40174805
Ulcerative colitis (UC) is a persistent intestinal disorder featuring periodic flare-ups of the colon's inner lining inflammation. Current therapeutic strategies, while effective in managing symptoms, are often limited by side effects and high costs. This study investigates the potential of pectin-loaded ferulic acid (PC-FA) nanoparticles as a novel therapeutic approach …
Challenges in Predicting Colonic Luminal and Tissue Concentrations of Mesalamine and Acetyl Mesalamine using Physiologically Based Biopharmaceutics Modeling
Publication Year: 2025 Source: Int J Pharm PMID: 40174807
Mesalamine is a standard first-line therapy for managing chronic inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Despite its established efficacy, the precise mechanism of action within enterocytes remains unclear. This study aimed to develop and validate Physiologically Based Biopharmaceutics Models (PBBM) for mesalamine (5-ASA) and its metabolite, …
Multi-disciplinary teams for Crohn's disease: Who should be presented?
Publication Year: 2025 Source: Surgeon PMID: 40175195 DOI: 10.1016/j.surge.2025.03.002
BACKGROUND: Multi-disciplinary team (MDT) conferences are used within the realm of colorectal surgery for both benign and malignant disease to assist in both diagnostic workup and to guide treatment. Usually, teams encompass colorectal surgery (CRS), gastroenterology (GE), pathology and radiology. Although it is believed that MDT discussion is associated with …
Identification of ulcerative colitis diagnostic markers from differentially expressed genes shared with Hirschsprung disease
Publication Year: 2025 Source: Sci Rep PMID: 40175429
Hirschsprung disease (HSCR) and ulcerative colitis (UC) exhibit overlapping features, with studies indicating a high incidence of UC among individuals with HSCR, suggesting a potential link worth exploring at the genetic level. This study aimed to identify differentially expressed genes (DEGs) common to both conditions and evaluate their diagnostic and …
Unmet Healthcare Needs Among People with Inflammatory Bowel Disease: A Canadian Cross-Sectional Population-Representative Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40175793 DOI: 10.1007/s10620-025-09015-w
PURPOSE: Despite current standards of care, many people with inflammatory bowel disease (IBD) experience significant disease complications and gaps in care. To better understand and address unmet healthcare needs, we need population-level evidence on perceived unmet healthcare needs in people with IBD. Our objective was to compare self-reported unmet healthcare …
Pyoderma gangrenosum in a patient with multiple sclerosis under natalizumab treatment: a case report
Publication Year: 2025 Source: BMC Neurol PMID: 40175973 DOI: 10.1186/s12883-025-04146-z
BACKGROUND: Pyoderma Gangrenosum (PG) is often considered an immune-mediated disease. Up to 50% of PG cases - a rare, non-infectious inflammatory skin disease characterized by painful necrotic ulcers -are associated with underlying systemic diseases like Rheumatoid Arthritis (RA), and Inflammatory Bowel Disease (IBD), moreover with monoclonal antibody therapy. CASE PRESENTATION: …
Perspectives of Adolescents and Young Adults With Inflammatory Bowel Disease on a Biopsychosocial Transition Intervention: Qualitative Interview Study
Publication Year: 2025 Source: JMIR Pediatr Parent PMID: 40176441 DOI: 10.2196/64618
BACKGROUND: The transition from pediatric to adult health care marks a complex and pivotal process for adolescents and young adults with inflammatory bowel disease (IBD). This group requires support regarding disease self-management, skill development, and system navigation in preparation for transition. Evidence-based interventions are needed to promote optimal health and …
The Visibility and Performance of Small Bowel Video Capsule Endoscopy With and Without Pre-Procedural Purge Preparation in the Same Patients
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40176636 DOI: 10.1111/jgh.16954
BACKGROUND: Small bowel (SB) video capsule endoscopy (VCE) is an established diagnostic tool for the investigation of SB pathologies. Despite clinical studies and a few meta-analyses, an area of continuing controversy is the role of pre-procedural bowel preparation. OBJECTIVES: We compared the visibility and performance of VCE with and without …
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