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Case report: Inflammatory bowel disease in Hermansky-Pudlak syndrome type 3 due to novel variant in HPS3
Publication Year: 2025 Source: Front Genet PMID: 40176789 DOI: 10.3389/fgene.2025.1465527
BACKGROUND: Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder with phenotypic and genetic heterogeneity, characterized by oculocutaneous albinism, bleeding diathesis, and other specific subtypes such as colitis. HPS3 is caused by biallelic mutations in HPS3. Patients with HPS3 have milder symptoms and were rarely reported to be involved in …
Is a rare CXCL8 gene variant a new possible cause or course factor of inflammatory bowel disease?
Publication Year: 2025 Source: Front Immunol PMID: 40176809 DOI: 10.3389/fimmu.2025.1562618
INTRODUCTION: The pathogenesis of inflammatory bowel diseases (IBD) involves genetic, environmental, immunological, and microbial factors; however, it remains unclear. Pro-inflammatory interleukin 8 (IL-8), encoded by the CXCL8 gene, assumes a crucial chemotactic role in leukocyte migration. METHODS: This study aimed to investigate whether an association exists between IBD and two …
Myocarditis associated with Salmonella enterica serovar Weltevreden gastroenteritis in medical practitioner; case report from South India
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40177284
Salmonella enterica serovar Weltevreden, a non-typhoidal serovar, has emerged as a significant foodborne pathogen, particularly in Southeast Asian countries. While it is commonly associated with gastroenteritis and foodborne outbreaks, it can also lead to invasive infections in immunocompromised adults and neonates. This case report presents a rare instance of myocarditis …
Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages
Publication Year: 2025 Source: Acta Pharm Sin B PMID: 40177575 DOI: 10.1016/j.apsb.2024.12.012
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases the incidence of colorectal cancer (CRC). In the pathophysiology of IBD, ubiquitination/deubiquitination plays a critical regulatory function. Josephin domain containing 2 (JOSD2), a deubiquitinating enzyme, controls cell proliferation and carcinogenesis. However, its role in IBD …
Defense mechanisms and inflammatory bowel diseases: a narrative review
Publication Year: 2025 Source: Res Psychother PMID: 40178111 DOI: 10.4081/ripppo.2025.854
Growing evidence highlights the crucial role of defense mechanisms in the context of chronic diseases. However, few studies have evaluated the impact of these implicit emotion regulation strategies on the adaptation processes related to inflammatory bowel diseases (IBD). This narrative review aimed to explore the role of defense mechanisms in …
External Evaluation of Population Pharmacokinetic Models of Ustekinumab in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Ther Drug Monit PMID: 40178486 DOI: 10.1097/FTD.0000000000001329
BACKGROUND: Population pharmacokinetic (popPK) models are essential tools for optimizing ustekinumab (UST) dosing for the treatment of inflammatory bowel disease (IBD) through therapeutic drug monitoring. The external validation of these models is necessary to ensure their predictive performance and clinical utility. The aim of the study was to externally validate …
Exendin-4 imaging based on gastrointestinal GLP-1R targets for IBD diagnosis and efficacy assessment
Publication Year: 2025 Source: Eur J Nucl Med Mol Imaging PMID: 40178570 DOI: 10.1007/s00259-025-07197-z
PURPOSE: Diagnosis of inflammatory bowel disease (IBD) involves history-taking and invasive procedures that primarily evaluate localized intestinal structures. Notably, glucagon-like peptide 1 (GLP-1) and its receptor (GLP-1R) have been established as potent participants in various inflammatory diseases. This study aimed to investigate the potential of molecular imaging targeting GLP-1R in …
Downregulation of MT2-MMP and MT5-MMP in ulcerative colitis serves a diagnostic predictor and potential therapeutic targets
Publication Year: 2025 Source: Mol Biol Rep PMID: 40178713 DOI: 10.1007/s11033-025-10449-8
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by persistent inflammation and tissue remodeling. Matrix metalloproteinases (MMPs) play a key role in extracellular matrix degradation, and their dysregulation is implicated in IBD. However, the specific role of membrane-type MMPs (MT-MMPs) in UC remains underexplored. This study investigates …
CT imaging of and therapy for inflammatory bowel disease via low molecular weight dextran coated ceria nanoparticles
Publication Year: 2025 Source: Nanoscale PMID: 40178819 DOI: 10.1039/d4nr04994b
Inflammatory bowel disease (IBD) affects approximately 3.1 million individuals in the U.S., causing deleterious symptoms such as bloody diarrhea and leading to an increased risk of colorectal cancer. Effective imaging is crucial for diagnosing and managing IBD, as it allows for accurate assessment of disease severity, guides treatment decisions, and …
Bioimpedance Phase Angle as a Diagnostic Tool of Nutritional Status in Children with Crohn's Disease on Exclusive Enteral Nutrition Therapy: One-Year Follow-Up Study
Publication Year: 2025 Source: J Med Food PMID: 40178970
Exclusive enteral nutrition (EEN) is highly effective in achieving remission and improving nutritional status in pediatric Crohn's disease (CD), commonly associated with altered body mass composition (BC). Bioimpedance analysis (BIA) with phase angle (PA) assessment is a noninvasive, reliable tool in screening for BC alterations. In the present study we …
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