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The critical role of COL1A1 revealed by integrated bioinformatics analysis of differentially-expressed genes in colorectal cancer and inflammatory bowel disease
Publication Year: 2025 Source: Comput Biol Med PMID: 40179807 DOI: 10.1016/j.compbiomed.2025.110116
PURPOSE: There is an urgent need to identify biomarkers of tumorigenesis for colitis-associated cancer (CAC) as early cancer detection remains crucial for patients with inflammatory bowel disease (IBD). This in silico study examines the relationship between IBD and CAC, with particular regard to differentially-expressed genes (DEGs). METHODS: Integrated bioinformatics tools …
α1,3 Fucosyltransferase VII Improves Intestinal Immune Homeostasis in Inflammatory Bowel Disease by Enhancing Regulatory T-Cell Intestinal Homing and Immunosuppression
Publication Year: 2025 Source: Gastroenterology PMID: 40180293 DOI: 10.1053/j.gastro.2025.02.041
BACKGROUND & AIMS: Regulatory T cells (Tregs) play a critical role in maintaining tissue immune homeostasis, but they are relatively insufficient at inflammatory intestinal sites in patients with inflammatory bowel disease (IBD). However, what controls Treg homing to the intestine in IBD is unknown. METHODS: alpha1,3 Fucosyltransferase VII (FUT7) expression …
Bone Broth Benefits: How Its Nutrients Fortify Gut Barrier in Health and Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40180691 DOI: 10.1007/s10620-025-08997-x
Bone broth is a traditional nutrient revered by different people from ancient times to the modern era as a remedy for various illnesses. This review investigates the nutritional components of bone broth, focusing primarily on the most abundant amino acids and minerals saturated in bone broth and their impact on …
Frequency of Biological Drug Use in Older Patients with Immune-Mediated Inflammatory Diseases: Results from the Large-Scale Italian VALORE Distributed Database Network
Publication Year: 2025 Source: BioDrugs PMID: 40180772
BACKGROUND: Limited real-world data on biological drug use in older patients with immune-mediated inflammatory diseases (IMIDs) exist despite these drugs carrying serious risks in this population. OBJECTIVE: We aimed to describe the frequency and persistence of biological drug use in older patients (>/= 65 years) with IMID, including inflammatory bowel …
Inflammatory bowel disease in a young female patient with a novel de novo TRAF3 frameshift variant responsive to ustekinumab: a case report
Publication Year: 2025 Source: Intest Res PMID: 40181234 DOI: 10.5217/ir.2024.00190
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an anti-inflammatory molecule that negatively regulates the non-canonical nuclear factor-kappaB pathway. Although TRAF3 haploinsufficiency (TRAF3 HI) can influence innate and adaptive immune cells, its effect on inflammatory bowel disease (IBD) development remains unclear. Here, we report the first case of severe early-onset …
FOSB is a key factor in the genetic link between inflammatory bowel disease and acute myocardial infarction: multiple bioinformatics analyses and validation
Publication Year: 2025 Source: BMC Med Genomics PMID: 40181401 DOI: 10.1186/s12920-025-02129-0
BACKGROUND: Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, is associated with an increased risk of Acute Myocardial Infarction (AMI). The genetic mechanisms underlying this link are not well understood. METHODS: We downloaded IBD and AMI-related microarray datasets from the NCBI Gene Expression Omnibus (GEO) database. Differentially …
Genomic prediction with kinship-based multiple kernel learning produces hypothesis on the underlying inheritance mechanisms of phenotypic traits
Publication Year: 2025 Source: Genome Biol PMID: 40181452 DOI: 10.1186/s13059-025-03544-3
BACKGROUND: Genomic prediction encompasses the techniques used in agricultural technology to predict the genetic merit of individuals towards valuable phenotypic traits. It is related to Genome Interpretation in humans, which models the individual risk of developing disease traits. Genomic prediction is dominated by linear mixed models, such as the Genomic …
Development of Akkermansia Muciniphila Membrane-Coated Mesoporous Silica Nanoparticles with a Cerium Oxide Core for Inflammatory Bowel Disease Treatment
Publication Year: 2025 Source: Adv Healthc Mater PMID: 40181608 DOI: 10.1002/adhm.202405159
While convenient for patient compliance, the efficacy of oral treatments for inflammatory bowel disease (IBD) is often compromised by the dynamic and harsh chemical environment of the gastrointestinal tract, presenting challenges for effective therapeutic management. The pathological complexity of IBD frequently involves multiple factors such as oxidative stress, immune dysregulation, …
Editorial: Obesity and Outcomes on Advanced Therapy in Ulcerative Colitis-The Fat of the Matter
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40181611 DOI: 10.1111/apt.70097
No Abstract
Identification of Potential Functional Modules and Diagnostic Genes for Crohn's Disease Based on Weighted Gene Co-expression Network Analysis and LASSO Algorithm
Publication Year: 2025 Source: Turk J Gastroenterol PMID: 40181741
BACKGROUND/AIMS: Accurate diagnosis of Crohn's disease (CD) is paramount due to its resemblance to other inflammatory bowel diseases. Early and precise diagnosis plays a pivotal role in tailoring personalized treatments, thereby enhancing the quality of life for CD patients. MATERIALS AND METHODS: Differential gene expression analysis was conducted to identify …
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