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Automated inflammatory bowel disease detection using wearable bowel sound event spotting
Publication Year: 2025 Source: Front Digit Health PMID: 40182584 DOI: 10.3389/fdgth.2025.1514757
INTRODUCTION: Inflammatory bowel disorders may result in abnormal Bowel Sound (BS) characteristics during auscultation. We employ pattern spotting to detect rare bowel BS events in continuous abdominal recordings using a smart T-shirt with embedded miniaturised microphones. Subsequently, we investigate the clinical relevance of BS spotting in a classification task to …
Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 40182599
BACKGROUND: A deficiency of gammadelta T cells has been described in Crohn's disease (CD). AIM: To analyze the gene expression of interleukin 7 (IL-7) and its receptors in the tissues of patients with CD. METHODS: We studied the peripheral blood of 80 patients with CD, comparing them with a group …
Involvement of the NLRP3/IL-1β pathway in activation and effector functions of γδT17 cells in patients with ulcerative colitis
Publication Year: 2025 Source: World J Gastroenterol PMID: 40182600
BACKGROUND: The interleukin-17 (IL-17) mediated aberrant immune-inflammatory response plays a paramount role in ulcerative colitis (UC). gammadeltaT17 cells are one of the critical sources of IL-17, but the role they play in UC remains under debate. AIM: To clarify the role of gammadeltaT17 cells in patients with mild-to-moderate UC. METHODS: …
Editorial: The microbiome in the development of gastrointestinal diseases
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40182773
No Abstract
CDC42 Regulatory Patterns Related To Inflammatory Bowel Disease and Hyperglycemia
Publication Year: 2025 Source: J Bioinform Syst Biol PMID: 40183002
As a member of the rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) family, Cdc42 represents a "switch" molecule, by changing from inactive (GDP-associated) to active form (GTP-associated) and vice versa. Cdc42 is activated by the guanine nucleotide exchange factors (GEFs), in contrast to GTPase-activating proteins (GAPs) which are responsable …
Who and how to choose combination therapy for inflammatory bowel disease: a comprehensive expert review
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 40183312 DOI: 10.1097/MOG.0000000000001097
PURPOSE OF REVIEW: Therapeutic options in inflammatory bowel disease (IBD) have expanded significantly. Patients often experience primary or secondary loss of response to biologics or small molecules therapy. Determining which patients may benefit from combination of two therapies remains a key question. RECENT FINDINGS: Combination therapy leverages complementary mechanisms of …
Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)
Publication Year: 2025 Source: Immunology PMID: 40183428 DOI: 10.1111/imm.13923
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD) and irritable bowel syndrome (IBS) are distinct gastrointestinal disorders. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis, while the roles of human endogenous retroviruses (HERVs) are under investigation. We aimed (a) to investigate whether the levels …
Clinical Impact of Primary Sclerosing Cholangitis on Outcomes of Inflammatory Bowel Disease Hospitalization: A Propensity Score Matching Analysis of the Nationwide Inpatient Sample
Publication Year: 2025 Source: J Dig Dis PMID: 40183746 DOI: 10.1111/1751-2980.13339
OBJECTIVE: We aimed to evaluate the effect of primary sclerosing cholangitis (PSC) on hospitalization outcomes of inflammatory bowel disease (IBD) patients. METHODS: This retrospective study used data from the Nationwide Inpatient Sample (NIS) database from January 1, 2019, to December 31, 2020, including adults (>/= 18 years) admitted and diagnosed …
Primary sclerosing cholangitis with PLKR and UGT1A1 mutation manifested as recurrent bile duct stones: A case report
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40184140
RATIONALE: Primary sclerosing cholangitis (PSC) is characterized by idiopathic intra- and extrahepatic bile duct inflammation and biliary fibrotic changes. Recurrent bile duct stones due to PLKR and UGT1A1 mutation is an extremely rare complications of PSC. PATIENT CONCERNS: A 26-year-old male patient complains a history of recurrent yellow skin and …
Assessment and Impact of Age on the Safety and Efficacy of Etrasimod in Patients With Ulcerative Colitis: A Post Hoc Analysis of Data From the ELEVATE UC Clinical Program
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40184206
BACKGROUND: Patient age can impact the safety and efficacy of ulcerative colitis (UC) treatments. Etrasimod is an oral, once daily (QD), selective sphingosine 1-phosphate1,4,5 receptor modulator for the treatment of moderately to severely active UC. Here, we evaluate the impact of age on etrasimod safety and efficacy in patients with …
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