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Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40184259
The global prevalence of ulcerative colitis (UC) and Crohn's disease (CD) is increasing, placing greater burdens on national health systems. The pathophysiology of diarrhea, the commonest debilitating symptom in patients with UC and CD, has been studied more extensively in UC, where it reflects defective colonic Na(+) absorption combined with …
Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiota Dysbiosis in Colitis by Scavenging Oxidative Stress and Restoring Immune Homeostasis
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40184333 DOI: 10.1021/acsami.4c22004
Inflammatory bowel disease (IBD) is a complex chronic intestinal disorder in which excessive oxidative stress, dysregulated immune response, and microbiota dysbiosis contribute to recurrent episodes of inflammation in the colonic mucosa. Current clinical treatments focusing solely on inflammation resolution often exhibit limited efficacy due to the inability to fundamentally improve …
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
Publication Year: 2025 Source: Cell PMID: 40185101
The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally derived RORgammat(+) Tregs (pTregs), which prevent food intolerance and inflammatory bowel disease. Recent studies suggested that RORgammat(+) antigen-presenting cells (APCs), which encompass rare dendritic cell (DC) subsets and type 3 innate lymphoid cells (ILC3s), are …
Influence of preoperative anti TNF alpha antibody therapy on postoperative recurrence of Crohn's disease
Publication Year: 2025 Source: Sci Rep PMID: 40185854
Anti-TNFalpha antibodies are effective in controlling intestinal inflammation caused by Crohn's disease. However, many patients undergo surgery due to diminished efficacy of the antibodies during maintenance therapy. Currently, the decision between intensification of TNFalpha therapy and surgery is difficult to make. The purpose of this study was to determine the …
Inflammatory bowel disease in paediatric rheumatological diseases
Publication Year: 2025 Source: Clin Rheumatol PMID: 40186043 DOI: 10.1007/s10067-025-07424-w
INTRODUCTION: Rheumatological diseases (RD) in childhood are systemic diseases that occur on the basis of auto-immunity or inflammation, and they can be accompanied by inflammatory bowel disease (IBD). When there is no knowledge of this association, the treatments applied may not be sufficient and/or treatments given for RD may even …
Biosimilars versus biological therapy in inflammatory bowel disease: challenges and targeting strategies using drug delivery systems
Publication Year: 2025 Source: Clin Exp Med PMID: 40186719 DOI: 10.1007/s10238-025-01558-6
Inflammatory bowel disease (IBD) is a multifactorial illness with a climbing prevalence worldwide. While biologics are commonly prescribed especially for severe cases, they may worsen patients' outcomes due to financial burden. Consequently, there has been an increased focus on biosimilars to improve overall disease outcomes by maintaining similar efficacy and …
The effect of Crohn's disease on outcomes after total hip arthroplasty
Publication Year: 2025 Source: Arch Orthop Trauma Surg PMID: 40186766
INTRODUCTION: Crohn's disease has been increasing in incidence globally and has several musculoskeletal manifestations including large joint arthritis. This study compares post-operative lengths of stay, healthcare costs, and complication rates between patients with and without Crohn's Disease (CD) following Total Hip Arthroplasty (THA). METHODS: Data were collected from the National …
Discovery of an ene-reductase initiating resveratrol catabolism in gut microbiota and its application in disease treatment
Publication Year: 2025 Source: Cell Rep PMID: 40186869
Resveratrol (RSV) is a plant-derived natural compound with multiple biological activities. Upon entering the intestine, RSV undergoes rapid metabolism and transformation by the gut microbiota. In this study, we isolated a bacterium capable of efficiently metabolizing RSV, Eggerthella lenta J01. Through induced enrichment transcriptomics and bioinformatic analyses, we identified an …
Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40186907 DOI: 10.1016/j.intimp.2025.114462
Inflammatory bowel disease (IBD) is an inflammatory disease of the intestine whose primary pathological presentation is the destruction of the intestinal epithelium. The intestinal epithelium, located between the lumen and lamina propria, transmits luminal microbial signals to the immune cells in the lamina propria, which also modulate the intestinal epithelium. …
Prevention and interception trials in inflammatory bowel disease: an international taskforce assessment on clinical trial design
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40187359 DOI: 10.1016/S2468-1253(24)00439-4
Therapeutic progress in inflammatory bowel disease (IBD) has hitherto focused on reducing inflammation to minimise long-term complications. However, strategies aimed at preventing IBD and attenuating its disease course are particularly appealing. This concept is derived from accumulating evidence for an "at-risk" preclinical state and the associations linking genetic background and …
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