Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Small molecule drug absorption in inflammatory bowel disease and current implementation in physiologically- based pharmacokinetic models
Publication Year: 2025 Source: Eur J Pharm Sci PMID: 40187540 DOI: 10.1016/j.ejps.2025.107095
Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestinal mucosa, with predominant localization in the colon in ulcerative colitis (UC) or affecting the entire length of the gastrointestinal tract in Crohn's disease (CD). Recent advances in the drug development space have been marked by a return …
Challenges in adherence to STRIDE-II: Perspectives from gastroenterologists and patients with inflammatory bowel disease
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40187559
INTRODUCTION: The treatment aims to achieve symptomatic remission, normalization of biomarkers such a fecal calprotectin, and endoscopic remission. Therefore, early recognition of inflammatory activity and timely therapeutic intervention are essential to improve the morbidity and mortality. OBJECTIVE: Evaluate the adherence among gastroenterologists and the patients compliance with medical recommendations in …
Functional alterations in colonic CD4+T and regulatory T cells drive immune imbalance in ulcerative colitis
Publication Year: 2025 Source: Immunol Lett PMID: 40187693
Immune imbalance plays a key role in the pathogenesis of ulcerative colitis (UC). The changes in CD4+ T cells and regulatory T cells (Tregs) in colonic T cells have an important relationship with UC. It is of great significance to elucidate the functional characteristics of CD4+ cells andTregs in UC …
Perineal wound complications after proctectomy for Crohn's disease: the impact of the omental pedicle flap and predictors of return to the operating room
Publication Year: 2025 Source: J Gastrointest Surg PMID: 40187722
BACKGROUND: The role of omental pedicle flaps (OPFs) in reducing the risk of perineal wound complications and postoperative pelvic abscesses in patients with Crohn's disease remains unclear. This study aimed to determine whether OPFs had any effect on the incidence of perineal wound complications requiring a return to the operating …
Medical management of acute severe ulcerative colitis in the hospitalized patient
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40187895 DOI: 10.1080/17474124.2025.2488884
INTRODUCTION: Approximately one in every four patients with ulcerative colitis will develop acute severe ulcerative colitis (ASUC). Historically, this was managed with intravenous steroids and surgery when steroids failed. The use of rescue therapy. AREAS COVERED: This review summarizes the latest research in the management of hospitalized patients with ASUC. …
Bayesian compositional generalized linear mixed models for disease prediction using microbiome data
Publication Year: 2025 Source: BMC Bioinformatics PMID: 40188058 DOI: 10.1186/s12859-025-06114-3
The primary goal of predictive modeling for compositional microbiome data is to better understand and predict disease susceptibility based on the relative abundance of microbial species. Current approaches in this area often assume a high-dimensional sparse setting, where only a small subset of microbiome features is considered relevant to the …
Congenital absence of omentum with short bowel syndrome: a case report
Publication Year: 2025 Source: J Med Case Rep PMID: 40188137
INTRODUCTION: Short bowel syndrome can manifest as either an inherited or acquired condition, with the inherited form occurring sporadically. Furthermore, the complete absence of the omentum at birth (congenital absence) is a highly uncommon event. CASE REPORT: This case report presents a unique confluence of these rare conditions in a …
The Role of Histology Alongside Clinical and Endoscopic Evaluation in the Management of IBD-A Narrative Review
Publication Year: 2025 Source: J Clin Med PMID: 40217934 DOI: 10.3390/jcm14072485
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions requiring continuous monitoring. Today, endoscopy is the gold standard for assessing disease activity, with histological evaluation providing additional insights. Studies suggest that persistent histological inflammation, despite endoscopic remission, may be associated with a higher …
Sexual Health in Women with Inflammatory Bowel Diseases: A Narrative Review
Publication Year: 2025 Source: Healthcare (Basel) PMID: 40218014 DOI: 10.3390/healthcare13070716
Background/Objectives: Inflammatory bowel diseases (IBDs), such as Crohn's disease and ulcerative colitis, have a significant impact on overall well-being. Sexual health, a critical component of overall well-being, is often compromised in individuals with IBD, especially in women, owing to physical, psychological, and social factors. This narrative review aims to synthesize …
Mediating Role of Negative Affectivity in the Association Between Lifetime Trauma and Gastrointestinal Symptoms
Publication Year: 2025 Source: Healthcare (Basel) PMID: 40218052 DOI: 10.3390/healthcare13070755
Background/Objectives: It is increasingly recognized that traumatic life experiences render individuals more vulnerable to gastrointestinal (GI) symptoms and chronic bowel conditions like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). In this study, we examined whether this effect is mediated by negative affectivity. Methods: A total of 281 participants …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide