Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Educational interventions to enhance support for balancing work and treatment in inflammatory bowel disease patients
Publication Year: 2025 Source: J Gastroenterol PMID: 40220044 DOI: 10.1007/s00535-025-02248-6
BACKGROUND: Inflammatory bowel disease (IBD) significantly impacts employment and work productivity, necessitating support for balancing work and treatment (SBWT). While SBWT systems have been formalized in Japan, awareness among healthcare professionals remains low. This study aimed to evaluate the effectiveness of an educational program on SBWT for healthcare professionals in …
The impact of disease and species differences on the intestinal CLCA4 gene expression
Publication Year: 2025 Source: J Mol Med (Berl) PMID: 40220130
The human chloride channel regulator, calcium-activated (CLCA) 4 is discussed as a driver of epithelial-to-mesenchymal transition as well as a biomarker for colorectal cancer (CRC) and ulcerative colitis. In contrast to humans, the Clca4 gene is duplicated in the mouse, a common model species to study gene functions. However, the …
Therapeutic intervention with anti-TNF alleviates colonic and hepatic toxicity induced by perfluorooctanoic acid (PFOA)
Publication Year: 2025 Source: Ecotoxicol Environ Saf PMID: 40220356 DOI: 10.1016/j.ecoenv.2025.118125
Perfluorooctanoic acid (PFOA) is a prevalent and chemically stable environmental contaminant. Our preliminary data suggest that chronic exposure to PFOA induces colonic damage in mice that resembles inflammatory bowel disease (IBD). Anti-TNF therapies are commonly used in the clinical management of IBD. Building upon our previous findings, we administered anti-TNF …
Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosis by Regulating Lipid Peroxidation and GPX4/ACSL4 in Colitis
Publication Year: 2025 Source: Phytomedicine PMID: 40220415
BACKGROUND: Ferroptosis in colonic epithelial cells has been implicated in the development of ulcerative colitis (UC) and the accompanying gut leakage. Scutellaria baicalensis Georgi (Scu) is widely used herb medicine for alleviating UC. PURPOSE: We aimed to clarify the therapeutic effect of Scu on UC by inhibiting intestinal epithelial cell …
Artificial Intelligence for Clinical Trial Facilitation, Lessons for Inflammatory Bowel Disease: A Scoping Review
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40220847 DOI: 10.1016/j.cgh.2025.01.030
BACKGROUND & AIMS: Despite major advances in many fields of science and technology, pharmaceutical research and development continues to be inefficient across multiple diseases. Inflammatory bowel disease (IBD) trials are also subject to high failure rates. The aim of this review was to give an overview of the available literature …
Modulation of FOXO3a Nuclear Localization by Linagliptin (BI-1356) reveals a new therapeutic target in chronic ulcerative colitis
Publication Year: 2025 Source: Eur J Pharm Sci PMID: 40221059
Globally, the incidence and prevalence rates of ulcerative colitis (UC) show a rising pattern. The limited efficacy and significant adverse effects associated with current treatment options underscore the need for novel therapeutic approaches. It has been found that linagliptin, a dipeptidyl peptidase-4 inhibitor, activates AMPK in different disease conditions. The …
The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases
Publication Year: 2025 Source: Autoimmun Rev PMID: 40221070
Autoimmune disorders can be described as inappropriate immune responses directed against self-antigens, which account for substantial healthcare concerns around the world. Immunosuppression or immune modulation are the main therapeutic modalities for autoimmune disorders. These modalities, however, impair the ability of the immune system to fight against infections, thereby predisposing to …
Multimodality Imaging of Small Bowel Crohn Disease
Publication Year: 2025 Source: Radiol Clin North Am PMID: 40221177 DOI: 10.1016/j.rcl.2024.10.002
Computed tomography enterography, magnetic resonance enterography, and bowel ultrasound are complementary tools central to diagnosing and monitoring Crohn disease. These modalities can identify active inflammation, penetrating, and stricturing disease. Crohn disease must be monitored frequently to guide therapy, and resolution of inflammation on imaging correlates directly with steroid-free clinical remission. …
Artificial Intelligence in Gastrointestinal Imaging: Advances and Applications
Publication Year: 2025 Source: Radiol Clin North Am PMID: 40221188
While artificial intelligence (AI) has shown considerable progress in many areas of medical imaging, applications in abdominal imaging, particularly for the gastrointestinal (GI) system, have notably lagged behind advancements in other body regions. This article reviews foundational concepts in AI and highlights examples of AI applications in GI tract imaging. …
Refining microbiome diversity analysis by concatenating and integrating dual 16S rRNA amplicon reads
Publication Year: 2025 Source: NPJ Biofilms Microbiomes PMID: 40221450
Understanding the role of human gut microbiota in health and disease requires insights into its taxonomic composition and functional capabilities. This study evaluates whether concatenating paired-end reads enhances data output for gut microbiome analysis compared to the merging approach across various regions of the 16S rRNA gene. We assessed this …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide