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Evaluation of dysplasias associated with inflammatory bowel disease-a single-center, retrospective, 5-year experience
Publication Year: 2025 Source: Pathol Oncol Res PMID: 40303424 DOI: 10.3389/pore.2025.1612105
INTRODUCTION: Several novel morphological variants of inflammatory bowel disease (IBD)- associated dysplasias have been described in recent years. The objective of our study was to reevaluate some of our IBD-associated neoplasia cases and retrospectively identify the so-called non-conventional dysplasias (NCDs). METHODS: We established a database of IBD patients registered between …
Comprehensive Characterization of the Oxidative Stress Profiles in Neonatal Necrotizing Enterocolitis
Publication Year: 2025 Source: Int J Med Sci PMID: 40303487
Objective: This study aims to portray the characteristics of oxidative stress (OS) in cases of Necrotizing enterocolitis (NEC), identify the hub genes and associated mechanisms involved, and explore potential drugs for NEC. Methods: We performed a comprehensive analysis integrating bulk-RNA sequencing and single-cell RNA sequencing datasets, coupled with various techniques …
Treatment Persistence and Variations in Prescribing Oral, Injectable, and Inhaled Corticosteroids: A Population-Based Drug Utilisation Study
Publication Year: 2025 Source: Pharmacoepidemiol Drug Saf PMID: 40304070
PURPOSE: To examine variation in oral, injectable, and inhaled corticosteroid (CS) prescribing in primary care, exploring treatment persistence and coverage. METHODS: We examined patient-level electronic health records from English general practices in the Clinical Practice Research Datalink Aurum database. We delineated a cohort of new users of oral, injectable, or …
Mechanical Thrombectomy of Acute Aortic Thromboembolism Using Stent-Retriever Thrombectomy Device in a Dog
Publication Year: 2025 Source: J Am Anim Hosp Assoc PMID: 40304448
A 12 yr old, 6.11 kg, neutered male spitz dog was referred for acute hind limb paralysis. The dog had a history of inflammatory bowel disease and hyperadrenocorticism. Abdominal ultrasonography revealed a large thrombus at the aortic trifurcation, involving both iliac arteries. Therefore, the dog underwent mechanical thrombectomy using a …
AI-Assisted Glucocorticoid Treatment Response Prediction of Active Ulcerative Active Patients
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40304464
BACKGROUND: Glucocorticoids are recommended for the induction and remission phase of ulcerative colitis (UC). Early identification of glucocorticoid therapy response contributes to more precise treatment management. We aim to use deep learning model to predict glucocorticoid response prognosis in active UC. METHODS: From January 2006 to December 2023, 485 intestinal …
Chromatin profiling to identify biomarkers in inflammatory bowel diseases
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 40304726 DOI: 10.1097/MOG.0000000000001104
PURPOSE OF REVIEW: Chromatin plays a critical role in gene regulation and disease pathogenesis. In inflammatory bowel disease (IBD), alterations in chromatin structure contribute to disease heterogeneity and impact treatment responses. This review explores chromatin accessibility and chromatin-associated proteins as biomarkers for IBD and highlights recent technological advancements enabling targeted …
Shared genetic association between inflammatory bowel disease and acute myeloid leukemia: insights from mendelian randomization and transcriptomic analyses
Publication Year: 2025 Source: Inflamm Res PMID: 40304766 DOI: 10.1007/s00011-025-02038-z
BACKGROUND: Observational studies suggest that a history of inflammatory bowel disease (IBD) is associated with the onset of acute myeloid leukemia (AML), often attributed to drug use. However, these findings are inconsistent. This study aimed to assess the causal relationship between IBD and AML, identify shared pathogenesis, and discover diagnostic …
Dietary Relationships between Obesity and Inflammatory Bowel Diseases: A Narrative Review of Diets Which May Promote Both Diseases
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40304971
The pandemic of obesity preceded global spread of Inflammatory Bowel diseases by almost 2 decades. A pathogenic relationship has been described between obesity and inflammatory bowel diseases, but Crohn;s disease may be selectively impacted. The role of diet in pathogenesis has also gained significant support in the last few decades. …
Gut-directed therapeutics in inflammatory bowel disease
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 40305008 DOI: 10.1097/MOG.0000000000001099
PURPOSE OF REVIEW: Tissue-directed therapies (TDTs) provide potential advantages, including improved tolerance, safety, and efficacy. This review provides a conceptual framework for understanding intestinal TDT and summarizes the current landscape of TDT in inflammatory bowel disease (IBD). RECENT FINDINGS: Vedolizumab, a mAb targeting the gut homing alpha4beta7 integrin, served as …
Ameliorative Effect of Banana Lectin in TNBS-Induced Colitis in C57BL/6 Mice Relies on the Promotion of Antioxidative Mechanisms in the Colon
Publication Year: 2025 Source: Biomolecules PMID: 40305159
Background: The global burden of inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, is constantly rising. As IBDs significantly reduce patients' quality of life, prevention and efficient treatment of IBDs are of paramount importance. Although the molecular mechanisms underlying IBD pathogenesis are still not completely understood, numerous studies …
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