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Fecal Calprotectin as a Prognostic Biomarker for Mortality and Renal Outcomes in Chronic Kidney Disease
Publication Year: 2025 Source: Biomolecules PMID: 40305332
BACKGROUND/OBJECTIVES: Fecal calprotectin (FC) is a biomarker of intestinal inflammation widely used in the assessment of gastrointestinal disorders. However, its role in chronic kidney disease (CKD) remains unclear. Given the growing recognition of the gut-kidney axis in CKD pathophysiology, this study aimed to investigate the association between FC levels, systemic …
Rectal Perforation Induced by Taenia saginata: A Case Report
Publication Year: 2025 Source: Foodborne Pathog Dis PMID: 40305344
Taenia saginata, commonly known as the beef tapeworm, is a prevalent zoonotic cestode with an estimated global prevalence of 60-70 million carriers. This parasite is frequently located in the gastrointestinal tract, and previous reports have described complications such as acute appendicitis, Meckel's diverticulitis, pancreatitis, cholecystitis, liver abscess, intestinal obstruction, and …
Role of endoscopic ultrasound as a predictor of histological healing in ulcerative colitis
Publication Year: 2025 Source: Ann Med PMID: 40305512
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with rising global prevalence.Histological healing (HH) is a key treatment target associated with better long-term outcomes. Although endoscopic ultrasound (EUS) is known to be related to both clinical and endoscopic activity in UC, its role in defining HH remains unclear. …
Clinical outcomes in Crohn's disease patients with short bowel syndrome on home parenteral nutrition are comparable to those with short bowel syndrome from other etiologies
Publication Year: 2025 Source: Clin Nutr PMID: 40305998
BACKGROUND & AIMS: Patients with short bowel syndrome (SBS) and chronic intestinal failure require home parenteral nutrition (PN) support. The main cause of SBS remains Crohn's disease (CD), and complications in this cohort versus SBS from other etiologies remains to be determined. We therefore sought to investigate whether patients with …
Transfer of bone marrow niche-residential regulatory T cells ameliorates experimental colitis
Publication Year: 2025 Source: Cell Immunol PMID: 40306133 DOI: 10.1016/j.cellimm.2025.104952
BACKGROUND: Adoptive transfer of regulatory T cells (Tregs) has been proposed as a next-generation treatment approach for the treatment of various inflammatory or autoimmune disorders(Amini et al., 2022; Bluestone et al., 2023, 2015; Dall'Era et al., 2019; Chandran et al., 2017; Laukova and Glatman Zaretsky, 2023; Voskens et al., 2023; …
A single dose of nicotine modulates heart rate variability in rats with induced-ulcerative colitis
Publication Year: 2025 Source: Auton Neurosci PMID: 40306144
BACKGROUND AND AIMS: Nicotine, a widely used toxic substance, has various receptors scattered throughout the body that have shown opposite effects on inflammatory disorders. However, the effects of nicotine on heart rate variability in ulcerative colitis are unclear. Therefore, the present study aimed to determine the effect of acute nicotine …
Rejection and graft vasculopathy secondary to effects of Crohn's disease in a heart-transplanted child
Publication Year: 2025 Source: Am J Transplant PMID: 40306436
Patients require immunosuppression after heart transplantation. Conditions such as Crohn's disease can impact tacrolimus absorption and pharmacokinetics. Subtherapeutic tacrolimus levels can lead to rejection and development of donor-specific antibodies (DSA), resulting in the development of cardiac allograft vasculopathy. We present a boy who underwent an ABO blood groupincompatible heart transplant …
CMTM3 Promotes Colitis-associated Carcinogenesis via CLTC Stabilization and Modulation of VE-cadherin
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40306490
BACKGROUND & AIMS: Inflammatory bowel disease leads to increased risk of developing colitis-associated colon cancer (CAC). CMTM3 has a higher methylation level in colon cancer, and accumulating evidence suggests that chemokine-like factor-like MARVEL transmembrane domain-containing member 3 (CMTM3) participates in inflammation and cancer development. METHODS: We explored the signs of …
Bioactive chitosan-BSA Maillard-derived chrysin-loaded nanoparticles: A gastroprotective, biomucoadhesive approach for enhanced oral therapy in ulcerative colitis
Publication Year: 2025 Source: Carbohydr Polym PMID: 40306769 DOI: 10.1016/j.carbpol.2025.123537
The current limitations of oral nanomedicines such as aminosalicylates, immunosuppressants, corticosteroids, and antibiotics include the toxic byproducts from nanocarrier synthesis, poor targeting and retention within the inflamed colon, delayed release at inflammation sites, susceptibility to gastric degradation, reduced efficacy under hypoxic conditions, MUC2 homeostasis disruption, and insufficiently addressing the disease's …
British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease
Publication Year: 2025 Source: Gut PMID: 40306978 DOI: 10.1136/gutjnl-2025-335023
Patients with inflammatory bowel disease (IBD) remain at increased risk for colorectal cancer and death from colorectal cancer compared with the general population despite improvements in inflammation control with advanced therapies, colonoscopic surveillance and reductions in environmental risk factors. This guideline update from 2010 for colorectal surveillance of patients over …
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