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Varicella Development after Infliximab Therapy for Refractory Pouchitis in Post-surgical Ulcerative Colitis
Publication Year: 2025 Source: Intern Med PMID: 40307038
A boy in his late teens had undergone proctocolectomy for refractory ulcerative colitis eight months ago. Two months earlier, he had developed pouchitis and received intensive treatment with infliximab (IFX). Two days after the IFX injection, a fever and generalized rash appeared. Varicella zoster virus (VZV) antigen positivity in the …
Increased CT Attenuation of Pericolic Adipose Tissue as a Noninvasive Marker of Disease Severity in Ulcerative Colitis
Publication Year: 2025 Source: Korean J Radiol PMID: 40307197
OBJECTIVE: Accurate evaluation of inflammation severity in ulcerative colitis (UC) can guide treatment strategy selection. The potential value of the pericolic fat attenuation index (FAI) on CT as an indicator of disease severity remains unknown. This study aimed to assess the diagnostic accuracy of pericolic FAI in predicting UC severity. …
Inflammatory bowel disease has stages of epidemiology that can be tracked across global regions
Publication Year: 2025 Source: Nature PMID: 40307392
No Abstract
Aberrant T follicular helper cells generated by T(H)17 cell plasticity in the gut promote extraintestinal autoimmunity
Publication Year: 2025 Source: Nat Immunol PMID: 40307450
Much remains unknown regarding T follicular helper 17 (T(FH)17) cells commonly found in autoimmune patients. We previously showed that (and here ask why) egress of gut segmented filamentous bacteria (SFB)-induced T(FH) cells from Peyer's patches (PP) to systemic sites promotes arthritis. We found splenic T(FH)17 cells are gut derived. Functional …
Global evolution of inflammatory bowel disease across epidemiologic stages
Publication Year: 2025 Source: Nature PMID: 40307548 DOI: 10.1038/s41586-025-08940-0
During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania(1). At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized …
Diet outperforms microbial transplant to drive microbiome recovery in mice
Publication Year: 2025 Source: Nature PMID: 40307551
A high-fat, low-fibre Western-style diet (WD) induces microbiome dysbiosis characterized by reduced taxonomic diversity and metabolic breadth(1,2), which in turn increases risk for a wide array of metabolic(3-5), immune(6) and systemic pathologies. Recent work has established that WD can impair microbiome resilience to acute perturbations such as antibiotic treatment(7,8), although …
Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation
Publication Year: 2025 Source: EMBO Rep PMID: 40307620 DOI: 10.1038/s44319-025-00464-y
Disruption of the circadian clock is associated with the development of inflammatory bowel disease (IBD), but the underlying mechanisms remain unclear. Here, we observe that mice in the early active phase (Zeitgeber time 12, ZT12) of the circadian clock are more tolerant to dextran sodium sulfate (DSS)-induced colitis, compared to …
Vedolizumab-steroid combination therapy improves long-term prognosis in patients with ulcerative colitis
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40307703
BACKGROUND: In real-world clinical settings, the clinical efficacy of vedolizumab (VDZ) in patients with ulcerative colitis (UC) remains unclear. In this study, we aimed to evaluate the efficacy of prednisolone (PSL)-VDZ combination therapy in patients with UC. METHODS: Changes in the clinical activity index (CAI), blood test results, and the …
Inflammatory Bowel Disease and Joint Surgery: A 20-Year Cohort Study of Arthroplasty and Arthritis Risks
Publication Year: 2025 Source: Cureus PMID: 40308415 DOI: 10.7759/cureus.81494
Background Patients with inflammatory bowel disease (IBD) have a higher risk of adverse outcomes after total hip arthroplasty (THA) and total knee arthroplasty (TKA) compared to the general population. However, existing literature has not fully elucidated the risk of IBD patients to undergo arthroplasty for treatment of arthritis. Therefore, the …
HMGB1: new biomarker and therapeutic target of autoimmune and autoinflammatory skin diseases
Publication Year: 2025 Source: Front Immunol PMID: 40308590
High-mobility group box 1 (HMGB1) is expressed in almost all human cells. During cell activation and cell death, the nucleoprotein HMGB1 can translocate to the extracellular space, thus mediating the early inflammatory response as an alarmin or damage-associated molecular pattern (DAMP). Extracellular HMGB1 interacts with immune cells by binding to …
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