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Whole genome sequencing informs SNP-based breeding strategies to safeguard genetic diversity in captive African lions
Publication Year: 2025 Source: Front Vet Sci PMID: 40308689 DOI: 10.3389/fvets.2025.1577726
INTRODUCTION: African lions (Panthera leo) face severe population declines, making captive breeding programs essential for conservation. However, genetic data scarcity in such programs elevates inbreeding risks and threatens genetic diversity. METHODS: Using next-generation sequencing (NGS), we analyzed genome-wide genetic markers from 10 captive African lions at Xinjiang Tianshan Wildlife Park. …
LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway
Publication Year: 2025 Source: Drug Des Devel Ther PMID: 40308738
OBJECTIVE: LianChuang ZhiXue Liquid (LCZXL) enema, one of the classic Chinese medicine prescriptions, in which herbal decoction enema acts directly on the intestines, is clinically effective in patients with ulcerative colitis (UC). However, its specific molecular mechanism has not been clarified to explore the underlying macular mechanism of LCZXL enema …
Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis
Publication Year: 2025 Source: World J Gastroenterol PMID: 40308799
BACKGROUND: Epstein-Barr virus (EBV) infection of the intestinal mucosa is associated with surgical risk in ulcerative colitis (UC); however, the exact effect remains unclear. AIM: To determine whether EBV infection can predict the need for colectomy and to develop a surgical risk predictive model. METHODS: This was a single-center retrospective …
Application of aggregation-induced emission materials in gastrointestinal diseases
Publication Year: 2025 Source: World J Gastroenterol PMID: 40308804
Aggregation-induced emission (AIE) is a phenomenon characterized by certain fluorescent molecules that exhibit weak or no luminescence in solution but demonstrate significantly enhanced luminescence upon aggregation. Accordingly, AIE materials have successfully addressed the limitations associated with aggregation-caused quenching effects and have made significant progress in the application of various fields …
Creeping fat: A promising radiological predictor in small bowel Crohn's disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 40308808
In this manuscript, we comment on the article by Hasnaoui et al. Specifically, we delve into the characteristic manifestation of Crohn's disease (CD) known as creeping fat (CF). Our primary focus is to investigate the potential of imaging features of CF in predicting the response of small bowel CD to …
Bibliometric analysis of research trends and prospective directions of Akkermansia muciniphila from 2010 to 2024
Publication Year: 2025 Source: Front Microbiol PMID: 40309112
BACKGROUND: Akkermansia muciniphila (A. muciniphila) is an emerging probiotic with potential impact on human health, and there is a growing interest in this area, but an overall analysis of research trends is lacking. This study conducted a detailed bibliometric analysis and visualization of A. muciniphila research to examine the current …
The Vulnerability of the Heart During Diarrhea: A Case Report on Pericarditis Linked to Inflammatory Bowel Disease
Publication Year: 2025 Source: J Community Hosp Intern Med Perspect PMID: 40309294 DOI: 10.55729/2000-9666.1465
INTRODUCTION: Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease, often involves extraintestinal manifestations, affecting up to 40% of patients. Cardiovascular complications, although rare, can include pericarditis, the most common cardiac manifestation in IBD. CASE PRESENTATION: We report the case of a 34-year-old male with a long-standing history …
Intensified Upadacitinib Dosing for Adolescent Patients with Acute Severe Ulcerative Colitis
Publication Year: 2025 Source: Children (Basel) PMID: 40310056
Background/Objectives: In adolescent patients with ulcerative colitis refractory to anti-tumor necrosis factor (TNF) therapy, episodes of acute severe ulcerative colitis (ASUC) require hospitalization or surgery. Upadacitinib can be a potential colectomy-sparing agent in adult ASUC patients receiving intensified dosing. Methods: This case series evaluates clinical outcomes of intensified rescue upadacitinib …
Pediatric Inflammatory Bowel Disease in Romania: The First Epidemiological Study of the North-West Region (2000-2020)
Publication Year: 2025 Source: Children (Basel) PMID: 40310072 DOI: 10.3390/children12040403
Background: Inflammatory bowel disease (IBD) represents a group of disorders with increasing incidence in the pediatric population worldwide. There are limited data on pediatric IBD (pIBD) epidemiology in Eastern Europe and none so far from Romania. The aim of our study was to evaluate incidence rates and time trends for …
A Theoretical Link Between the GH/IGF-1 Axis and Cytokine Family in Children: Current Knowledge and Future Perspectives
Publication Year: 2025 Source: Children (Basel) PMID: 40310145
BACKGROUND/OBJECTIVES: Growth in childhood and adolescence is influenced by a complex interaction of genetic, environmental, and hormonal factors, with growth hormone (GH) and insulin-like growth factor 1 (IGF-1) playing crucial roles in linear growth and development. However, chronic inflammation, often detected in situations like inflammatory bowel disease and juvenile idiopathic …
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