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Clear Cell Renal Carcinoma in an Ulcerative Colitis Patient Under Short-Term Immunosuppressive Therapy: A Case Report
Publication Year: 2025 Source: Clin Pract PMID: 40310301
Background/Objectives: Renal cell cancer is a rare occurrence in patients with ulcerative colitis (UC), with no clearly demonstrated association between UC and an increased risk of renal malignancies. In this article, a case report concerning this relationship is presented. Methods: Our research group presented a case of clear cell renal …
Paediatric Congenital Enteropathies: Clinical and Histological Review
Publication Year: 2025 Source: Diagnostics (Basel) PMID: 40310351 DOI: 10.3390/diagnostics15080946
Paediatric congenital enteropathies (PCEs) are a group of rare inherited diseases with a typical early onset in life. Prompt identification and treatment are crucial to avoid potentially fatal consequences. This review aims to provide a paradigmatic framework for clinical and histological identification of PCEs, with an emphasis on congenital conditions …
Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting
Publication Year: 2025 Source: Science PMID: 40310938
The gut microbiota of mammals possess distinctive metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system, called GlycoCaging, that is based on bespoke glycoconjugates of a complex plant oligosaccharide. GlycoCaging of exemplar anti-inflammatory drugs …
Discovery and optimization of ibuprofen derivatives as the NF-κB/iNOS pathway inhibitors for the treatment of ulcerative colitis
Publication Year: 2025 Source: Bioorg Chem PMID: 40311243
In this study, a series of novel ibuprofen (Ibu) hybrid molecules with aminothiazole heterocycles were designed, synthesized and evaluated for their anti-inflammatory potency in vitro and in vivo. Among all these derivatives, compounds 6 and 8 effectively inhibited the production of NO (with 87 %, 79 % NO-inhibitory rates, respectively) …
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation
Publication Year: 2025 Source: Phytomedicine PMID: 40311595 DOI: 10.1016/j.phymed.2025.156803
BACKGROUND: Citrinin (CTN) is a mycotoxin that is difficult to eliminate and easy to ingest. Chronic exposure to CTN can lead to inflammatory bowel disease (IBD). The herb Koumine has strong anti-inflammatory activity and is considered a candidate for the treatment of IBD. PURPOSE: To investigate the effect of Koumine …
Pesticides and Inflammatory Bowel Disease: A Critical Look at the Hidden Gaps in the Exposome-Disease Link
Publication Year: 2025 Source: Gastroenterology PMID: 40311819
No Abstract
l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids
Publication Year: 2025 Source: Food Chem Toxicol PMID: 40311999
Ulcerative colitis (UC) is closely related to impaired intestinal barrier function and imbalanced gut microbial communities. l-theanine shows great potential in maintaining intestinal integrity and regulating the gut microbiota and associated short-chain fatty acids (SCFAs). However, whether l-theanine can alleviate UC by repairing the intestinal barrier through these regulatory processes …
Aseptic abscess syndrome as first manifestation of Crohn's disease - a case report
Publication Year: 2025 Source: BMC Pediatr PMID: 40312290
BACKGROUND: There exist multiple extraintestinal manifestations of inflammatory bowel disease. The most common are arthritis, aphthous stomatitis, or uveitis. Aseptic abscess syndrome is not usually included among these extraintestinal manifestations. In our case report, we present a rare case of aseptic abscess syndrome as the first manifestation of inflammatory bowel …
Ge-SAND: an explainable deep learning-driven framework for disease risk prediction by uncovering complex genetic interactions in parallel
Publication Year: 2025 Source: BMC Genomics PMID: 40312319
BACKGROUND: Accurate genetic risk prediction and understanding the mechanisms underlying complex diseases are essential for effective intervention and precision medicine. However, current methods often struggle to capture the intricate and subtle genetic interactions contributing to disease risk. This challenge may be further exacerbated by the curse of dimensionality when considering …
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