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Dietary inflammatory potential, genetic predisposition, and incidence of Crohn's disease and ulcerative colitis
Publication Year: 2025 Source: Nutr Metab (Lond) PMID: 40312362
BACKGROUND: Evidence for a potential link between dietary inflammatory potential and inflammatory bowel disease is limited, and the moderating role of genetic susceptibility remains to be assessed. OBJECTIVE: To evaluate energy-adjusted dietary inflammatory index (E-DII) for the associations with incident Crohn's disease (CD) and ulcerative colitis (UC) and the role …
Gut microbiota modulate intestinal inflammation by endoplasmic reticulum stress-autophagy-cell death signaling axis
Publication Year: 2025 Source: J Anim Sci Biotechnol PMID: 40312439 DOI: 10.1186/s40104-025-01196-8
The intestinal tract, a complex organ responsible for nutrient absorption and digestion, relies heavily on a balanced gut microbiome to maintain its integrity. Disruptions to this delicate microbial ecosystem can lead to intestinal inflammation, a hallmark of inflammatory bowel disease (IBD). While the role of the gut microbiome in IBD …
Uncovering shared genetic features between inflammatory bowel disease and systemic lupus erythematosus
Publication Year: 2025 Source: Sci Rep PMID: 40312552 DOI: 10.1038/s41598-025-98991-0
Inflammatory bowel disease (IBD) is an autoimmune disease (AD) characterized by chronic, relapsing intestinal inflammation. Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement and overactivation of both innate and adaptive immunity. The extra intestinal manifestations (EIMs) that commonly occur in IBD include many of the organ …
MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases
Publication Year: 2025 Source: Immunol Res PMID: 40312574 DOI: 10.1007/s12026-025-09633-6
Monocytes are innate immune cells that drive the chronicity of various inflammatory diseases. Monocyte migration to inflamed tissues involves multiple steps of interaction with the vascular endothelium and the extracellular matrix (ECM), a process mediated through conformational transitions in cell surface integrins. We previously described motile sperm domain-containing protein 2 …
Challenges and insights in detecting early inflammation in DSS-induced colitis using chemiluminescence
Publication Year: 2025 Source: Photochem Photobiol Sci PMID: 40312581
BACKGROUND: Ulcerative colitis (UC) is a complex inflammatory condition with limited non-invasive tools to monitor early-stage inflammation. This study aimed to investigate the early stages of inflammation in acute and chronic murine models of dextran sulfate sodium (DSS)-induced colitis using in vivo and ex vivo chemiluminescence imaging. METHODS: Two DSS-induced …
Early intestinal ultrasound response to biologic and small molecule therapy is accurate to predict treat-to-target endoscopic outcomes in children with ulcerative colitis: results from the prospective super sonic-UC study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40312920
BACKGROUND AND AIMS: Stride-II recommends monitoring early biomarker targets to achieve treat-to-target (T2T) endoscopic remission (ER) in ulcerative colitis (UC). Predictive capabilities of intestinal ultrasound (IUS) for ER remain unknown. We evaluated IUS response to predict ER in children with UC. METHODS: Prospective longitudinal cohort study of children with UC …
Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti-TNF-Alpha Agents in the Patients With UC: A Case Report
Publication Year: 2025 Source: J Clin Apher PMID: 40313140
Ulcerative colitis (UC) is a chronic inflammatory condition requiring lifelong management, with anti-tumor necrosis factor alpha (anti-TNF-alpha) agents often used for refractory cases. However, secondary loss of response (LOR) to these agents, due to anti-drug antibodies, poses a significant therapeutic challenge. This report describes a case where granulocyte and monocyte …
Are single nucleotide polymorphisms underutilized for guiding treatment of inflammatory bowel disease?
Publication Year: 2025 Source: Immunol Cell Biol PMID: 40313162 DOI: 10.1111/imcb.70029
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD), ulcerative colitis (UC) and IBD unclassified (IBDU), significantly impacts quality of life. Despite significant advances in the management of the conditions, responses to treatments vary greatly, and this is due partly to our natural genetic variation. Here we will review the evidence …
A Mushroom Based Prebiotic Supplement Pilot Study Among Patients with Crohn's Disease
Publication Year: 2025 Source: J Diet Suppl PMID: 40313234
Data on a mushroom based prebiotic supplementation in patients with Crohn's disease (CD) in western population is scarce. In this pilot trial, we aimed to assess the clinical efficacy and fecal microbial compositional and functional alterations associated with 'Mycodigest,' a commercial prebiotic supplement composed of three mushroom extracts. Patients with …
Large language models for extracting histopathologic diagnoses of colorectal cancer and dysplasia from electronic health records
Publication Year: 2025 Source: medRxiv PMID: 40313292 DOI: 10.1101/2024.11.27.24318083
BACKGROUND: Accurate data resources are essential for impactful medical research, but available structured datasets are often incomplete or inaccurate. Recent advances in open-weight large language models (LLMs) enable more accurate data extraction from unstructured text in electronic health records (EHRs) but have not yet been thoroughly validated for challenging diagnoses …
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