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Anticancer and Anti-Inflammatory Potential of Coptisine as a Planar Quaternary Benzo[C]Phenanthridine Alkaloid With G-Quadruplex DNA Telomeric Induction Activity
Publication Year: 2025 Source: Drug Dev Res PMID: 40317769 DOI: 10.1002/ddr.70071
Coptisine, an isoquinoline-based phytochemical, exhibits a broad spectrum of biological activities, including anticancer and anti-inflammatory properties. Its planar chemical structure allows for the induction of anticancer effects by forming telomeric G-quadruplex structures. Despite its promising medicinal benefits, the clinical utilization of this compound is limited by critical shortcomings such as …
Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40317876 DOI: 10.1002/ueg2.70024
Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1-Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered osmoregulation. Conversely, lymphocytic colitis lacks genetic associations and …
Long-Term Outcomes Following Withdrawal of Anti-Tumour Necrosis Factor Treatment in Inflammatory Bowel Disease Patients in Remission: The Exit Long-Term Study of GETECCU
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40317957 DOI: 10.1111/apt.70172
BACKGROUND: The EXIT trial found no difference in sustained remission at 12 months between inflammatory bowel disease (IBD) patients in remission who withdrew anti-TNF therapy [withdrawal arm (WA)] and those who maintained treatment [maintenance arm (MA)]. AIMS: To compare the long-term risk of relapse between these groups and assess the …
Kurarinone and Nor-kurarinone inhibit NLRP3 inflammasome activation and regulate macrophage polarization against ulcerative colitis
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40318276
Activation of NOD-like receptor protein 3 (NLRP3) can lead to the production of inflammatory factors and perturbation of macrophage polarization, leading to an intestinal immune imbalance that promotes the progression of ulcerative colitis (UC). In this study, we investigated the therapeutic effect of Kurarinone and Nor-kurarinone on UC and their …
Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
Publication Year: 2025 Source: Phytomedicine PMID: 40318528
BACKGROUND: Colitis-associated colon cancer (CAC) is a serious gastrointestinal malignancy, with a significantly increased incidence among patients with inflammatory bowel disease, posing major challenges to patients' quality of life and prognosis. Modern research highlights Formononetin (FN) for its significant anti-inflammatory and extensively studied anti-cancer properties; however, its precise mechanisms, particularly …
ATF3 restoration as a potential strategy in managing ulcerative colitis: Implications from Sishen pill research
Publication Year: 2025 Source: Phytomedicine PMID: 40318535
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options, particularly for moderate-to-severe cases. The present study evaluated the therapeutic potential of Sishen Pill (SSP) through Activating Transcription Factor 3 (ATF3). METHODS: Colonic biopsy samples were collected from 11 UC patients and 6 healthy controls (HCs). …
A hierarchy of intestinal antigens instructs the CD4(+) T cell receptor repertoire
Publication Year: 2025 Source: Immunity PMID: 40318631 DOI: 10.1016/j.immuni.2025.04.011
Intestinal CD4(+) T cells that are specific for self-, diet-, or commensal-derived antigens are critical for host tolerance but must also be tightly regulated to prevent aberrant activation and conditions like inflammatory bowel disease (IBD). However, it is unclear how the antigen source and location dictate the intestinal TCR repertoire. …
Comprehensive computational strategies for multi-target drug discovery in inflammatory bowel disease utilizing bioactive compounds
Publication Year: 2025 Source: Sci Rep PMID: 40319156 DOI: 10.1038/s41598-025-98771-w
Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition that encompasses ulcerative colitis (UC) and Crohn's disease (CD). Targeting both inflammation and the epithelial barrier simultaneously can significantly improve symptom management in IBD, as a promising strategy. In this study, we focused on addressing both inflammation and the epithelial barrier. …
ECCO Topical Review on Predictive Models on Inflammatory Bowel Disease Disease Course and Treatment Response
Publication Year: 2025 Source: J Crohns Colitis PMID: 40319340 DOI: 10.1093/ecco-jcc/jjaf073
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) poses a clinical challenge due to its variable progression and treatment response. Despite the development of predictive models, their clinical application remains limited due to validation and methodological inconsistencies. The current topical review examines existing predictive models, assesses their relevance, and discusses the …
[Smoking and the digestive system]
Publication Year: 2025 Source: Orv Hetil PMID: 40319460
Smoking is considered to be the most important form among those that harm our health. Nicotine in itself as an additive can build a very strong addiction, but the main health damage is caused by the thousands of chemical components present in the tobacco cigarettes and the smoke, some of …
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