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From bedside to bench: Evaluating the effect of different storage and extraction techniques on protease activity analysis in inflammatory bowel disease patients
Publication Year: 2025 Source: J Pharm Biomed Anal PMID: 40319627 DOI: 10.1016/j.jpba.2025.116924
Proteolytic enzymes (proteases) are integral to multiple physiological processes, and increased protease activity is observed in inflammatory bowel disease (IBD) and other gastrointestinal diseases. Therefore, protease activity has been explored for potential diagnostic biomarkers and therapeutic targets. Faecal samples are commonly used to measure protease activities associated with gastrointestinal conditions …
Clostridium butyricum-induced balance in colonic retinol metabolism and short-chain fatty acid levels inhibit IgA-related mucosal immunity and relieve colitis developments
Publication Year: 2025 Source: Microbiol Res PMID: 40319662
Gut microbiota and their metabolites play a significant role in inflammatory bowel disease. Here, we attempted to determine the anti-inflammatory role of the probiotic Clostridium. butyricum (CB) in inflammatory bowel disease and identify the exact immune mechanism. The clinical significance of Clostridiales and CB was explored in patients with ulcerative …
The impact of Zataria multiflora on oxidative stress biomarkers and ulcerative colitis symptoms: A multicenter, triple-blind, placebo-controlled clinical trial
Publication Year: 2025 Source: Explore (NY) PMID: 40319670
BACKGROUND: Oxidative stress plays a crucial role in the pathogenesis of ulcerative colitis (UC), contributing to mucosal damage and inflammation. Zataria multiflora possesses antioxidant properties, yet clinical evidence regarding its effects in UC remains limited. This study aimed to evaluate the impact of Z. multiflora extract on oxidative stress markers …
Disrupting the immune homeostasis: the emerging role of macrophage ferroptosis in autoimmune diseases
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40319750 DOI: 10.1016/j.intimp.2025.114745
Autoimmune diseases are a class of chronic disorders characterized by the aberrant activation of the immune system, where macrophages play a central role in regulating immune responses during disease onset and progression. Ferroptosis, a form of iron-dependent programmed cell death, has recently attracted significant interest due to its involvement in …
Emerging manifestations of IL-17 immunomodulation in the gastrointestinal tract
Publication Year: 2025 Source: Hum Pathol PMID: 40319948 DOI: 10.1016/j.humpath.2025.105782
Interleukin 17 (IL-17) is a proinflammatory cytokine that is commonly dysregulated in autoimmune diseases. Biologics targeting IL-17 (ixekizumab, secukinumab, brodalumab, bimekizumab) have been approved to treat conditions including psoriasis, psoriatic arthritis, and ankylosing spondylitis. Although inflammatory bowel disease (IBD) is characterized by dysregulated IL-17 signaling, IL-17 inhibitors have not shown …
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Publication Year: 2025 Source: Brain Behav Immun PMID: 40320015
BACKGROUND: Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysregulated immune response. Childhood adversity is an environmental risk factor with enduring effects on the immune system and may therefore be implicated in the aetiology of autoimmune disorders. …
Dysbiosis of the gut micro-flora aggravates symptoms and accelerates disease progression in MASLD-IBD Co-morbid mice through host-microbial metabolic imbalance
Publication Year: 2025 Source: Arch Biochem Biophys PMID: 40320060 DOI: 10.1016/j.abb.2025.110441
Studies have shown that dysregulation of intestinal microbial structure and co-metabolic imbalance caused by diet and other factors play important role in MASLD and IBD. However, it is unclear how host-microbial interactions differ in the two diseases, and what potential impact they have on accelerating disease progression. Our study aims …
Prevalence of opportunistic infections in Syrian inflammatory bowel disease patients on biologic therapy: a multi-center retrospective cross-sectional study
Publication Year: 2025 Source: BMC Infect Dis PMID: 40320559 DOI: 10.1186/s12879-025-11063-6
BACKGROUND: Hepatitis B, hepatitis C, cytomegalovirus (CMV), and tuberculosis (TB) pose significant risks to patients with inflammatory bowel disease (IBD) receiving biological therapy. However, data on the prevalence of these infections in Syria are scarce. METHODS: We conducted a retrospective chart review of IBD patients receiving biologic therapy at Damascus …
Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients
Publication Year: 2025 Source: J Crohns Colitis PMID: 40320713
BACKGROUND AND AIMS: Tofacitinib, a Janus kinase inhibitor, is approved for the treatment of moderate-to-severe ulcerative colitis. Nonetheless, 40-60% of patients will not respond adequately. The mechanisms underlying responses to tofacitinib remain unknown. METHODS: We applied single-cell and/or bulk RNA analysis to biopsies (n = 23 and 63, respectively) from …
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