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Development of a Korean Nutrition Model for In Silico Gut Microbiome Analyses Integrated With Nutrigenomics
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 40320851
The gut microbiome plays a crucial role in human health and disease, with diet serving as a critical determinant of microbial composition and metabolic function. However, most existing nutrition databases are Western-centric, lacking comprehensive dietary information for non-Western populations, including Koreans. This limitation hinders the accuracy of in silico gut …
Anti-Inflammatory Effects of Spexin on Acetic Acid‑Induced Colitis in Rats via Modulating the NF-κB/NLRP3 Inflammasome Pathway
Publication Year: 2025 Source: J Biochem Mol Toxicol PMID: 40320895
Ulcerative colitis is a chronic inflammatory bowel disease characterized by inflammation and ulcers in the lining of the colon and rectum. Spexin is a novel peptide with antioxidant and anti-inflammatory properties. This study aims to elucidate the therapeutic effects and underlying mechanisms of spexin in mitigating acetic acid-induced colitis in …
Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery
Publication Year: 2025 Source: Exp Physiol PMID: 40321077
This narrative review provides an overview of protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes in patients undergoing orthopaedic surgery. Globally, the number of joint replacement procedures continues to rise annually, with beneficial outcomes in terms of pain relief and quality of life. However, orthopaedic surgery is …
IBD-related disability among patients with ulcerative colitis in China: a cross-sectional study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40321367 DOI: 10.1177/17562848251333989
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disorder that can lead to physical, psychological, and social disabilities among patients. OBJECTIVES: To evaluate the disability level in a cross-sectional study of Chinese patients with UC and identify factors associated with disability. DESIGN: This was a cross-sectional study. METHODS: Between April …
Cytomegalovirus-Induced Colitis Presenting as Acute Appendicitis in an Immunocompetent Patient With Ulcerative Colitis
Publication Year: 2025 Source: ACG Case Rep J PMID: 40321646
We report a rare case of cytomegalovirus (CMV) colitis presenting radiologically as acute appendicitis in an immunocompetent 71-year-old man known for ulcerative colitis. Although initial imaging revealed acute appendicitis, a lack of clinical improvement with antibiotic therapy prompted further evaluation with colonoscopy, which led to the diagnosis of CMV colitis …
Adalimumab Biosimilars Demonstrate Long-Term Durability and Cost-Effectiveness in Paediatric Inflammatory Bowel Disease: A Real-World Two-Centre European Cohort Study
Publication Year: 2025 Source: Biologics PMID: 40321667 DOI: 10.2147/BTT.S511248
PURPOSE: Adalimumab biosimilars are increasingly used in paediatric Inflammatory Bowel Disease (PIBD), but data remain limited. This study assessed their durability, efficacy, safety and cost implications in PIBD. PATIENTS AND METHODS: Consecutive PIBD patients who started adalimumab biosimilars between October 2018 and December 2023 at two centres in Scotland and …
Hydrogel derived from decellularized pig small intestine submucosa boosted the therapeutic effect of FGF-20 on TNBS-induced colitis in rats via restoring gut mucosal integrity
Publication Year: 2025 Source: Mater Today Bio PMID: 40321695
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by impaired intestinal mucosal barrier function, leading to persistent inflammation and tissue damage. Current therapies often fail to address barrier dysfunction, highlighting the need for innovative treatments. This study developed a novel therapeutic strategy by combining decellularized porcine small intestinal …
A Guide to De-escalation of Combination Therapy in Inflammatory Bowel Disease: A Retrospective Cohort Study
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40321837 DOI: 10.1093/crocol/otaf026
BACKGROUND: Advanced combination therapy with biologics and small molecules has seen more widespread implementation for inflammatory bowel disease (IBD). However, there is a paucity of data available to guide the successful de-escalation of combination therapy following the achievement of disease remission. Therefore, we pursued this retrospective study to evaluate our …
The Durability of Anti-TNF Therapy for Crohn's Disease Is Higher in Anti-TNF Naïve Patients and Increases With Proactive Therapeutic Drug Monitoring
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40321838 DOI: 10.1093/crocol/otaf028
BACKGROUND: Antitumor necrosis factor (TNF) dose escalation is performed to improve therapeutic response and optimize outcomes in patients with Crohn's disease (CD). We aimed to describe the durability of anti-TNF therapy in patients with CD receiving escalated anti-TNF therapy, along with the overall durability of anti-TNF treatment between patients managed …
Global Patterns of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Prevalence, Epidemiology, and Risk Factors
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40321839 DOI: 10.1093/crocol/otaf024
BACKGROUND: Clostridioides difficile infection (CDI) is a well-recognized complication of inflammatory bowel disease (IBD) that has been associated with poor clinical outcomes. The objective of this study is to characterize the global incidence, risk factors and outcomes of CDI in patients with IBD. METHODS: A search of MEDLINE/PubMed, Scopus, and …
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