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Ethnic Disparities in the Management of Inflammatory Bowel Disease in Israel and Impact on Outcomes
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40321840 DOI: 10.1093/crocol/otaf025
BACKGROUND: In this nationwide study, we aimed to explore healthcare services utilization, medical management, and disease outcomes of inflammatory bowel diseases (IBD) across the 2 major ethnic groups in Israel. METHODS: We utilized a cohort including all patients diagnosed with IBD in Israel since 2005. The primary outcome was steroid …
Characterization of the salivary microbiome of adults with inflammatory bowel disease
Publication Year: 2025 Source: J Oral Microbiol PMID: 40322049 DOI: 10.1080/20002297.2025.2499923
BACKGROUND: Perturbations of the gut microbiota in patients with inflammatory bowel disease (IBD) have been extensively characterised, but changes to the oral microbiome remain understudied. This study aimed to evaluate the oral microbiome of adults with IBD and of matched controls. METHODS: Saliva samples and data were obtained from a …
Incidence of Inflammatory Bowel Disease in Children
Publication Year: 2025 Source: Gastroenterology Res PMID: 40322194 DOI: 10.14740/gr2007
BACKGROUND: Many of the patients with inflammatory bowel disease (IBD) are children and adolescents, and the incidence of pediatric IBD is increasing. However, understanding epidemiological trends is crucial for effective prevention and treatment and reducing the local and global burden of IBD. Little data exist regarding the incidence of IBD …
A Rare Case of Terminal Ileal Diverticulitis: Clinical Presentation, Diagnosis, and Management
Publication Year: 2025 Source: Cureus PMID: 40322392
Diverticulitis is an acute inflammatory condition that typically affects the colon. Diverticulitis of the ileum is rare, with most cases reported in the terminal ileum, and is often triggered by an underlying infection, obstruction, or ischemia. Clinically, ileal diverticulitis presents with symptoms similar to colonic diverticulitis, such as abdominal pain, …
The Interplay of Coping Strategies and Quality of Life in Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: Middle East J Dig Dis PMID: 40322565 DOI: 10.34172/mejdd.2025.409
BACKGROUND: This systematic review, grounded in coping theory, examines the relationship between coping strategies and quality of life (QoL) in patients with inflammatory bowel disease. It synthesizes current findings and guides future research to address existing knowledge gaps. METHODS: A comprehensive search of Scopus, PubMed, Google Scholar, and Web of …
Differentiating IL-23 Inhibitors in Crohn's Disease
Publication Year: 2025 Source: Drugs PMID: 40323342 DOI: 10.1007/s40265-025-02183-z
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, plays a critical role in intestinal homeostasis and inflammation and is strongly implicated in the pathogenesis of inflammatory bowel disease (IBD). Therapies targeting the p19 subunit of IL-23 have recently expanded the therapeutic options for IBD demonstrating efficacy and safety …
The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential
Publication Year: 2025 Source: Med Oncol PMID: 40323477 DOI: 10.1007/s12032-025-02761-x
The gastrointestinal mycobiome, comprising diverse fungal species, plays a significant role in gastrointestinal carcinogenesis and inflammatory bowel disease (IBD) pathogenesis. Recent studies have demonstrated that dysbiosis of the gut mycobiome, characterized by an overrepresentation of pathogenic fungi such as Candida albicans and Aspergillus, correlates with increased inflammation and cancer risk. …
Explainable artificial intelligence for prediction of refractory ulcerative colitis: analysis of a Japanese Nationwide Registry
Publication Year: 2025 Source: Ann Med PMID: 40323686
OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which remission is dependent on corticosteroid (CS) treatment. The diversity of disease pathophysiology necessitates optimal case-specific treatment selection. This study aimed to identify prognostic factors for refractory UC using a machine learning model based on nationwide registry data. METHODS: …
Diet and Risk for Incident Diverticulitis in Women : A Prospective Cohort Study
Publication Year: 2025 Source: Ann Intern Med PMID: 40324196
BACKGROUND: Patients with diverticulitis often attempt to control their diet with a particular focus on avoiding nuts and seeds. However, whether dietary patterns or dietary intake of nuts and seeds are associated with diverticulitis risk is poorly studied, particularly in women. OBJECTIVE: To determine whether select diets affect incident diverticulitis …
The sensory neuroimmune frontier
Publication Year: 2025 Source: Immunity PMID: 40324378
Sensing and recognition are key properties of both the immune and nervous systems. In the immune system, pattern recognition or antigen-specific receptors represent classic motifs in innate and adaptive immunity, respectively. In the nervous system, there is a major anatomic division between how we sense stimuli from within the body …
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