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Integrating transcriptomics, metabolomics, and microbiomics to explore the mechanism of action of bran-fried Atractylodes lancea rhizome polysaccharide in ameliorating the enhanced pharmacological effects of dextran sodium sulfate-induced colitis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40324703
ETHNOPHARMACOLOGICAL RELEVANCE: Atractylodes lancea (Thunb.) DC. is used in China as a folk medicine for gastrointestinal disorder treatment, and its effect on treating gastrointestinal disorders is enhanced when it is fried in bran. Atractylodes lancea rhizome polysaccharide (ALP) are a group of active substances in Atractylodes lancea rhizome,ALP has good …
A Multimodal Therapeutic Strategy for Inflammatory Bowel Disease Using MicroRNA-146a Mimic Encapsulated in Lipid Nanoparticles
Publication Year: 2025 Source: Mol Pharm PMID: 40324972 DOI: 10.1021/acs.molpharmaceut.5c00014
Dysregulated microRNAs (miRNAs) have significant potential as diagnostic tools for various chronic diseases; however, their therapeutic applications remain largely unexplored. Given their capacity to regulate multiple pathways, miRNAs are promising candidates for treating pleiotropic diseases, such as inflammatory bowel disease (IBD). In our study, we conducted a comprehensive review of …
Detection of Inflammatory Bowel Disease Activity by Non-invasive Biomarkers: Still a Long Way Ahead
Publication Year: 2025 Source: Recent Adv Inflamm Allergy Drug Discov PMID: 40325805
No Abstract
The Way Forward in the Diagnosis and Treatment of IBDU in Children: A Global Perspective and Multidimensional Exploration
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40326014
No Abstract
Spatial mapping and geographic variation of inflammatory bowel disease in Canada: a population-based study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40326445 DOI: 10.1093/ecco-jcc/jjaf079
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) poses significant challenges to healthcare systems, with rising prevalence globally. To address challenges of health resource allocation and understand the geographic distribution of disease in Canada, we explored spatial mapping of IBD across Canada. METHODS: Data from 2009 to 2018 Canadian Community Health …
Association of Diet With Treatment Response in Dogs With Chronic Enteropathy: A Retrospective Multicenter Study
Publication Year: 2025 Source: J Vet Intern Med PMID: 40326642 DOI: 10.1111/jvim.70071
BACKGROUND: Hydrolyzed protein diets are commonly used in the first-line approach to the treatment of dogs with naive-chronic enteropathy (naive-CE). OBJECTIVES: To characterize the responses of naive-CE dogs transitioned to a hydrolyzed diet and to assess the efficacy of an additional dietary trial in dogs with NRE. ANIMALS: Eighty-one dogs …
Clinical Application of the Degradable Stent-Secured Intrapouch Bypass in IPAA
Publication Year: 2025 Source: Dis Colon Rectum PMID: 40326660
BACKGROUND: IPAA is the standard surgical treatment for ulcerative colitis. However, IPAA has a risk of anastomotic leakage after pouch reconstruction, which may lead to significant morbidity, additional surgeries, and, in many cases, a dysfunctional pouch. This study introduces a technique that enhances the safety of IPAA. IMPACT OF INNOVATION: …
Being a Writer
Publication Year: 2025 Source: Dis Colon Rectum PMID: 40326668 DOI: 10.1097/DCR.0000000000003795
No Abstract
Non-Typhoidal Salmonella Infections and Inflammatory Bowel Disease Risk: New Findings and Multidimensional Perspectives for Future Research
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40326745
No Abstract
Detailed mapping of mesothelioma cases in Denmark to identify areas with elevated risk: a nationwide population-based study
Publication Year: 2025 Source: Scand J Work Environ Health PMID: 40326864
OBJECTIVES: Previous studies mapping pleural mesothelioma in Denmark have found that the risk varies between Danish regions. However, evaluating disease risk for such relatively large geographical units ignores any heterogeneity within the unit and can thus diminish more local spikes in risk, missing smaller areas of excess risk. In this …
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